Difference between revisions of "Adenomatoid tumour"

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#redirect [[Uterine_tumours#Adenomatoid_tumour]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Adenomatoid_tumour_-b-_very_high_mag.jpg
| Width      =
| Caption    = Adenomatoid tumour. [[H&E stain]].
| Micro      = small tubulocystic spaces lined by unremarkable mesothelium; the pseudotubular spaces are crossed by "thread-like bridging strands, usu. well-circumscribed
| Subtypes  =
| LMDDx      = [[lymphangioma]], [[leiomyoma]], [[vascular tumours]]
| Stains    =
| IHC        = calretinin +ve, CK7 +ve, AE1/AE3 +ve, WT1 +ve, CD31 -ve, desmin -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[uterus]], adnexa ([[fallopian tube]]/[[ovaries]]), others
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    = [[leiomyoma]], other adenxal masses
}}
'''Adenomatoid tumour''' is a rare benign tumour derived from the mesothelium.
 
It should '''not''' be confused with the [[bone tumour]] ''[[adamantinoma]]''.
==General==
*Grossly mimics leiomyoma.<ref name=pmid8543111>{{Cite journal  | last1 = Huang | first1 = CC. | last2 = Chang | first2 = DY. | last3 = Chen | first3 = CK. | last4 = Chou | first4 = YY. | last5 = Huang | first5 = SC. | title = Adenomatoid tumor of the female genital tract. | journal = Int J Gynaecol Obstet | volume = 50 | issue = 3 | pages = 275-80 | month = Sep | year = 1995 | doi =  | PMID = 8543111 }}
</ref>
*Benign tumour - derived from mesothelium.
*May be seen para[[testicle|testicular]].<ref name=pmid20223139>{{Cite journal  | last1 = González Resina | first1 = R. | last2 = Carranza Carranza | first2 = A. | last3 = Congregado Córdoba | first3 = J. | last4 = Conde Sánchez | first4 = JM. | last5 = Congregado Ruiz | first5 = CB. | last6 = Medina López | first6 = R. | title = [Paratesticular adenomatoid tumor: a report of nine cases]. | journal = Actas Urol Esp | volume = 34 | issue = 1 | pages = 95-100 | month = Jan | year = 2010 | doi =  | PMID = 20223139 }}
</ref>
 
==Microscopic==
Features:<ref>{{Ref GP|346}}</ref>
*Well-circumscribed lesion; however, ''not'' encapsulated.
*Small tubulocystic spaces lined by cytologically normal mesothelium.
**These pseudotubular spaces are crossed by "thread-like bridging strands" - '''key feature'''.<ref name=pmid19543245>{{Cite journal  | last1 = Sangoi | first1 = AR. | last2 = McKenney | first2 = JK. | last3 = Schwartz | first3 = EJ. | last4 = Rouse | first4 = RV. | last5 = Longacre | first5 = TA. | title = Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. | journal = Mod Pathol | volume = 22 | issue = 9 | pages = 1228-35 | month = Sep | year = 2009 | doi = 10.1038/modpathol.2009.90 | PMID = 19543245 }}</ref><ref name=pmid14571427>{{Cite journal  | last1 = Hes | first1 = O. | last2 = Perez-Montiel | first2 = DM. | last3 = Alvarado Cabrero | first3 = I. | last4 = Zamecnik | first4 = M. | last5 = Podhola | first5 = M. | last6 = Sulc | first6 = M. | last7 = Hora | first7 = M. | last8 = Mukensnabl | first8 = P. | last9 = Zalud | first9 = R. | title = Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors. | journal = Ann Diagn Pathol | volume = 7 | issue = 5 | pages = 273-7 | month = Oct | year = 2003 | doi =  | PMID = 14571427 }}</ref>
 
DDx:
*[[Lymphangioma]].
*[[Leiomyoma]], esp. lipoleiomyoma.
*[[Vascular tumours]].
 
===Images===
<gallery>
Image:Adenomatoid_tumour_-_low_mag.jpg | Adenomatoid tumour - low mag. (WC)
Image:Adenomatoid_tumour_-_intermed_mag.jpg | Adenomatoid tumour - intermed. mag. (WC)
Image:Adenomatoid_tumour_-_high_mag.jpg | Adenomatoid tumour - high mag. (WC)
Image:Adenomatoid_tumour_-b-_very_high_mag.jpg | Adenomatoid tumour - very high mag. (WC)
</gallery>
 
==IHC==
Features:<ref name=pmid16548294>{{Cite journal  | last1 = Canedo-Patzi | first1 = AM. | last2 = León-Bojorge | first2 = B. | last3 = de Ortíz-Hidalgo | first3 = C. | title = [Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases] | journal = Gac Med Mex | volume = 142 | issue = 1 | pages = 59-66 | month =  | year =  | doi =  | PMID = 16548294 }}
</ref>
*Calretinin +ve.
*AE1/AE3 +ve.
*CK7 +ve.<ref name=pmid22553816>{{Cite journal  | last1 = Terada | first1 = T. | title = An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube. | journal = Appl Immunohistochem Mol Morphol | volume = 20 | issue = 2 | pages = 173-6 | month = Mar | year = 2012 | doi =  | PMID = 22553816 }}</ref>
 
Others:<ref name=pmid22553816/>
*CK20 -ve.
*EMA -ve.
*HMB-45 -ve.
*Vimentin -ve.
*Desmin -ve.
*CD31 -ve.
*CD34 -ve.
*WT1 +ve.<ref name=pmid15084840>{{Cite journal  | last1 = Schwartz | first1 = EJ. | last2 = Longacre | first2 = TA. | title = Adenomatoid tumors of the female and male genital tracts express WT1. | journal = Int J Gynecol Pathol | volume = 23 | issue = 2 | pages = 123-8 | month = Apr | year = 2004 | doi =  | PMID = 15084840 }}</ref>
 
==See also==
*[[Uterine tumours]].
*[[Fallopian tube]].
*[[Benign multicystic mesothelioma]].
*[[Malignant mesothelioma]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Gynecologic pathology]]

Latest revision as of 15:38, 13 May 2016

Adenomatoid tumour
Diagnosis in short

Adenomatoid tumour. H&E stain.
LM small tubulocystic spaces lined by unremarkable mesothelium; the pseudotubular spaces are crossed by "thread-like bridging strands, usu. well-circumscribed
LM DDx lymphangioma, leiomyoma, vascular tumours
IHC calretinin +ve, CK7 +ve, AE1/AE3 +ve, WT1 +ve, CD31 -ve, desmin -ve
Site uterus, adnexa (fallopian tube/ovaries), others
Prevalence uncommon
Prognosis benign
Clin. DDx leiomyoma, other adenxal masses

Adenomatoid tumour is a rare benign tumour derived from the mesothelium.

It should not be confused with the bone tumour adamantinoma.

General

  • Grossly mimics leiomyoma.[1]
  • Benign tumour - derived from mesothelium.
  • May be seen paratesticular.[2]

Microscopic

Features:[3]

  • Well-circumscribed lesion; however, not encapsulated.
  • Small tubulocystic spaces lined by cytologically normal mesothelium.
    • These pseudotubular spaces are crossed by "thread-like bridging strands" - key feature.[4][5]

DDx:

Images

  • Adenomatoid tumour - low mag. (WC)

  • Adenomatoid tumour - intermed. mag. (WC)

  • Adenomatoid tumour - high mag. (WC)

  • Adenomatoid tumour - very high mag. (WC)

IHC

Features:[6]

  • Calretinin +ve.
  • AE1/AE3 +ve.
  • CK7 +ve.[7]

Others:[7]

  • CK20 -ve.
  • EMA -ve.
  • HMB-45 -ve.
  • Vimentin -ve.
  • Desmin -ve.
  • CD31 -ve.
  • CD34 -ve.
  • WT1 +ve.[8]

See also

References

  1. ↑ Huang, CC.; Chang, DY.; Chen, CK.; Chou, YY.; Huang, SC. (Sep 1995). "Adenomatoid tumor of the female genital tract.". Int J Gynaecol Obstet 50 (3): 275-80. PMID 8543111.
  2. ↑ González Resina, R.; Carranza Carranza, A.; Congregado Córdoba, J.; Conde Sánchez, JM.; Congregado Ruiz, CB.; Medina López, R. (Jan 2010). "[Paratesticular adenomatoid tumor: a report of nine cases].". Actas Urol Esp 34 (1): 95-100. PMID 20223139.
  3. ↑ Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 346. ISBN 978-0443069208.
  4. ↑ Sangoi, AR.; McKenney, JK.; Schwartz, EJ.; Rouse, RV.; Longacre, TA. (Sep 2009). "Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases.". Mod Pathol 22 (9): 1228-35. doi:10.1038/modpathol.2009.90. PMID 19543245.
  5. ↑ Hes, O.; Perez-Montiel, DM.; Alvarado Cabrero, I.; Zamecnik, M.; Podhola, M.; Sulc, M.; Hora, M.; Mukensnabl, P. et al. (Oct 2003). "Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors.". Ann Diagn Pathol 7 (5): 273-7. PMID 14571427.
  6. ↑ Canedo-Patzi, AM.; León-Bojorge, B.; de Ortíz-Hidalgo, C.. "[Adenomatoid tumor of the genital tract. Clinical, pathological and immunohistochemical study in 9 cases]". Gac Med Mex 142 (1): 59-66. PMID 16548294.
  7. ↑ 7.0 7.1 Terada, T. (Mar 2012). "An immunohistochemical study of adenomatoid tumors of the uterus and fallopian tube.". Appl Immunohistochem Mol Morphol 20 (2): 173-6. PMID 22553816.
  8. ↑ Schwartz, EJ.; Longacre, TA. (Apr 2004). "Adenomatoid tumors of the female and male genital tracts express WT1.". Int J Gynecol Pathol 23 (2): 123-8. PMID 15084840.
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