Difference between revisions of "Progesterone receptor"
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{{ Infobox immunostain | {{ Infobox immunostain | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Pulmonary meningothelial-like nodule - PR -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = PR staining in [[pulmonary meningothelial-like nodule]]. | ||
| Abbrev = PgR | | Abbrev = PgR | ||
| Synonyms = | | Synonyms = | ||
| Line 11: | Line 11: | ||
| Subspecial = | | Subspecial = | ||
| Pattern = nuclear staining | | Pattern = nuclear staining | ||
| Positive = | | Positive = many breast carcinomas, [[pulmonary meningothelial-like nodule]] | ||
| Negative = | | Negative = | ||
| Other = | | Other = | ||
}} | }} | ||
'''Progesterone receptor''', abbreviated '''PgR''', is a common [[immunostain]]. | '''Progesterone receptor''', abbreviated '''PgR''', is a common [[immunostain]]. | ||
==General== | ==General== | ||
*Nuclear stain. | *Nuclear stain. | ||
==Positive== | ==Positive== | ||
*[[Breast carcinoma]] - most. | *[[Breast carcinoma]] - most. | ||
*[[ | **Neuroendocrine carcinoma of the breast.<ref>{{Cite journal | last1 = Lavigne | first1 = M. | last2 = Menet | first2 = E. | last3 = Tille | first3 = JC. | last4 = Lae | first4 = M. | last5 = Fuhrmann | first5 = L. | last6 = Bonneau | first6 = C. | last7 = Deniziaut | first7 = G. | last8 = Melaabi | first8 = S. | last9 = Ng | first9 = CCK. | title = Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast. | journal = Mod Pathol | volume = 31 | issue = 1 | pages = 68-82 | month = Jan | year = 2018 | doi = 10.1038/modpathol.2017.107 | PMID = 28884749 }}</ref> | ||
*[[Meningioma]] - most except for fibromatous subtype.<ref>{{Cite journal | last1 = Schnegg | first1 = JF. | last2 = Gomez | first2 = F. | last3 = LeMarchand-Beraud | first3 = T. | last4 = de Tribolet | first4 = N. | title = Presence of sex steroid hormone receptors in meningioma tissue. | journal = Surg Neurol | volume = 15 | issue = 6 | pages = 415-8 | month = Jun | year = 1981 | doi = | PMID = 7280951 }}</ref><ref>{{Cite journal | last1 = Tilzer | first1 = LL. | last2 = Plapp | first2 = FV. | last3 = Evans | first3 = JP. | last4 = Stone | first4 = D. | last5 = Alward | first5 = K. | title = Steroid receptor proteins in human meningiomas. | journal = Cancer | volume = 49 | issue = 4 | pages = 633-6 | month = Feb | year = 1982 | doi = | PMID = 7055777 }}</ref> | |||
*[[Pulmonary meningothelial-like nodule]]. | |||
*[[Endometrioid endometrial adenocarcinoma]]. | |||
===Occasionally positive=== | ===Occasionally positive=== | ||
Lung adenocarcinoma.<ref>{{Cite journal | last1 = Berardi | first1 = R. | last2 = Morgese | first2 = F. | last3 = Santinelli | first3 = A. | last4 = Onofri | first4 = A. | last5 = Biscotti | first5 = T. | last6 = Brunelli | first6 = A. | last7 = Caramanti | first7 = M. | last8 = Savini | first8 = A. | last9 = De Lisa | first9 = M. | title = Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex. | journal = Oncotarget | volume = 7 | issue = 50 | pages = 82648-82657 | month = Dec | year = 2016 | doi = 10.18632/oncotarget.12244 | PMID = 27690341 }}</ref> | *[[Lung adenocarcinoma]].<ref name=pmid27690341>{{Cite journal | last1 = Berardi | first1 = R. | last2 = Morgese | first2 = F. | last3 = Santinelli | first3 = A. | last4 = Onofri | first4 = A. | last5 = Biscotti | first5 = T. | last6 = Brunelli | first6 = A. | last7 = Caramanti | first7 = M. | last8 = Savini | first8 = A. | last9 = De Lisa | first9 = M. | title = Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex. | journal = Oncotarget | volume = 7 | issue = 50 | pages = 82648-82657 | month = Dec | year = 2016 | doi = 10.18632/oncotarget.12244 | PMID = 27690341 }}</ref> | ||
*[[Synovial sarcoma]].<ref>{{Cite journal | last1 = Boulagnon-Rombi | first1 = C. | last2 = Fleury | first2 = C. | last3 = Fichel | first3 = C. | last4 = Lefour | first4 = S. | last5 = Marchal Bressenot | first5 = A. | last6 = Gauchotte | first6 = G. | title = Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics. | journal = J Neuropathol Exp Neurol | volume = 76 | issue = 4 | pages = 289-298 | month = 04 | year = 2017 | doi = 10.1093/jnen/nlx008 | PMID = 28340171 }}</ref> | |||
==Negative== | ==Negative== | ||
*[[Endocervical adenocarcinoma]]. | |||
==See also== | ==See also== | ||
*[[Breast pathology]]. | *[[Breast pathology]]. | ||
*[[Endometrium with changes due to selective progesterone receptor modulators]]. | |||
==References== | ==References== | ||
Latest revision as of 18:14, 30 August 2023
| Progesterone receptor | |
|---|---|
| Immunostain in short | |
 PR staining in pulmonary meningothelial-like nodule. | |
| Abbreviation | PgR |
| Normal staining pattern | nuclear staining |
| Positive | many breast carcinomas, pulmonary meningothelial-like nodule |
Progesterone receptor, abbreviated PgR, is a common immunostain.
General
- Nuclear stain.
Positive
- Breast carcinoma - most.
- Neuroendocrine carcinoma of the breast.[1]
- Meningioma - most except for fibromatous subtype.[2][3]
- Pulmonary meningothelial-like nodule.
- Endometrioid endometrial adenocarcinoma.
Occasionally positive
Negative
See also
References
- ↑ Lavigne, M.; Menet, E.; Tille, JC.; Lae, M.; Fuhrmann, L.; Bonneau, C.; Deniziaut, G.; Melaabi, S. et al. (Jan 2018). "Comprehensive clinical and molecular analyses of neuroendocrine carcinomas of the breast.". Mod Pathol 31 (1): 68-82. doi:10.1038/modpathol.2017.107. PMID 28884749.
- ↑ Schnegg, JF.; Gomez, F.; LeMarchand-Beraud, T.; de Tribolet, N. (Jun 1981). "Presence of sex steroid hormone receptors in meningioma tissue.". Surg Neurol 15 (6): 415-8. PMID 7280951.
- ↑ Tilzer, LL.; Plapp, FV.; Evans, JP.; Stone, D.; Alward, K. (Feb 1982). "Steroid receptor proteins in human meningiomas.". Cancer 49 (4): 633-6. PMID 7055777.
- ↑ Berardi, R.; Morgese, F.; Santinelli, A.; Onofri, A.; Biscotti, T.; Brunelli, A.; Caramanti, M.; Savini, A. et al. (Dec 2016). "Hormonal receptors in lung adenocarcinoma: expression and difference in outcome by sex.". Oncotarget 7 (50): 82648-82657. doi:10.18632/oncotarget.12244. PMID 27690341.
- ↑ Boulagnon-Rombi, C.; Fleury, C.; Fichel, C.; Lefour, S.; Marchal Bressenot, A.; Gauchotte, G. (04 2017). "Immunohistochemical Approach to the Differential Diagnosis of Meningiomas and Their Mimics.". J Neuropathol Exp Neurol 76 (4): 289-298. doi:10.1093/jnen/nlx008. PMID 28340171.