Difference between revisions of "Multifocal fibrosing thyroiditis"

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'''Multifocal fibrosing thyroiditis''' is a benign pathology of the [[thyroid]] that can mimic [[papillary thyroid carcinoma]].
'''Multifocal fibrosing thyroiditis''', abbreviated '''MFT''', is a benign pathology of the [[thyroid]] that can mimic [[papillary thyroid carcinoma]].


It is also known as ''multifocal sclerosing thyroiditis''.<ref name=pmid25353282>{{Cite journal  | last1 = Fellegara | first1 = G. | last2 = Rosai | first2 = J. | title = Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity. | journal = Am J Surg Pathol | volume = 39 | issue = 3 | pages = 416-24 | month = Mar | year = 2015 | doi = 10.1097/PAS.0000000000000337 | PMID = 25353282 }}</ref>
It is also known as '''multifocal sclerosing thyroiditis'''.<ref name=pmid25353282>{{Cite journal  | last1 = Fellegara | first1 = G. | last2 = Rosai | first2 = J. | title = Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity. | journal = Am J Surg Pathol | volume = 39 | issue = 3 | pages = 416-24 | month = Mar | year = 2015 | doi = 10.1097/PAS.0000000000000337 | PMID = 25353282 }}</ref>


==General==
*Uncommon - though may be under-recognized.
*Female predominant in largest series (93% of cases versus 7% of cases).<ref name=pmid25353282/>
==Microscopic==
Features:<ref name=pmid25353282/>
*Fibrotic foci - two foci required - '''key feature'''.
**May be: (1) sharply demarcated from the surround parenchyma (stellate or triangular) or (2) band-like.
Note:
*MFT on average has 16 foci of fibrosis. These foci range in size from approximately 0.35 to 15 mm.<ref name=pmid25353282/>
*Should '''not''' have have [[nuclear pseudoinclusion]]s or [[psammoma bodies]].<ref name=pmid25353282/>
DDx:<ref name=pmid25353282/>
*[[Hashimoto thyroiditis]].
*[[Adenomatoid hyperplasia of thyroid]].
*[[Papillary thyroid carcinoma]].
*[[Riedel thyroiditis]].
*Changes due to fine needle aspiration - should have hemosiderin, not multifocal.


==See also==
==See also==
*[[Riedel thyroiditis]].
*[[Riedel thyroiditis]].
*[[IgG4-related systemic diseases]].


==References==
==References==

Latest revision as of 15:41, 17 October 2017

Multifocal fibrosing thyroiditis, abbreviated MFT, is a benign pathology of the thyroid that can mimic papillary thyroid carcinoma.

It is also known as multifocal sclerosing thyroiditis.[1]

General

  • Uncommon - though may be under-recognized.
  • Female predominant in largest series (93% of cases versus 7% of cases).[1]

Microscopic

Features:[1]

  • Fibrotic foci - two foci required - key feature.
    • May be: (1) sharply demarcated from the surround parenchyma (stellate or triangular) or (2) band-like.

Note:

DDx:[1]

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Fellegara, G.; Rosai, J. (Mar 2015). "Multifocal fibrosing thyroiditis: report of 55 cases of a poorly recognized entity.". Am J Surg Pathol 39 (3): 416-24. doi:10.1097/PAS.0000000000000337. PMID 25353282.