Testicular metastasis: Difference between revisions
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| Caption = Testis with metastatic prostate carcinoma. [[H&E stain]]. (WC) | | Caption = Testis with metastatic prostate carcinoma. [[H&E stain]]. (WC) | ||
| Synonyms = testicle with metastatic disease | | Synonyms = testicle with metastatic disease | ||
| Micro = atypical cells between seminiferous tubules, negative for [[ | | Micro = atypical cells between seminiferous tubules, negative for [[GCNIS]], +/-lymphovascular invasion | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = [[Primary testicular carcinoid tumour]], [[germ cell tumours]], others | ||
| Stains = | | Stains = | ||
| IHC = IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, SALL4 -ve) | | IHC = IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, [[SALL4]] -ve) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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*[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | *[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | ||
*Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | *Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | ||
Most common in order:<ref name=pmid26066034/> | |||
*Prostate, lung, melanoma, kidney, GI tract. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Lack of [[ | *Lack of [[germ cell neoplasia in situ]] (GCNIS). | ||
*Atypical cells infiltrating between benign-appearing seminiferous tubules. | *Atypical cells infiltrating between benign-appearing seminiferous tubules. | ||
*+/-[[Lymphovascular invasion]]. | *+/-[[Lymphovascular invasion]]. | ||
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*Malignant [[sex cord stromal tumour]]. | *Malignant [[sex cord stromal tumour]]. | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
*[[Primary testicular carcinoid tumour]].<ref name=pmid30799770>{{cite journal |authors=Darré T, Doukouré B, Kouyaté M, Djiwa T, Kwamé D, Napo-Koura G |title=A rare testicular tumor: primary carcinoid tumor |journal=Tumori |volume=105 |issue=6 |pages=NP20–NP23 |date=December 2019 |pmid=30799770 |doi=10.1177/0300891619832263 |url=}}</ref> | |||
===Images=== | ===Images=== | ||
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*[[Metastasis]]. | *[[Metastasis]]. | ||
*[[Ovarian metastasis]]. | *[[Ovarian metastasis]]. | ||
*[[Testicular cancer]]. | |||
==References== | ==References== | ||