Difference between revisions of "Ballooning degeneration"

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==General==
==General==
*A form of apoptosis.<ref name=pmid17355088>{{Cite journal  | last1 = Yip | first1 = WW | last2 = Burt | first2 = AD | title = Alcoholic liver disease. | journal = Semin Diagn Pathol | volume = 23 | issue = 3-4 | pages = 149–60 | month =  | year =  2006| doi =  10.1053/j.semdp.2006.11.002| pmid = 17355088 }}</ref>
*A form of [[apoptosis]].<ref name=pmid17355088>{{Cite journal  | last1 = Yip | first1 = WW | last2 = Burt | first2 = AD | title = Alcoholic liver disease. | journal = Semin Diagn Pathol | volume = 23 | issue = 3-4 | pages = 149–60 | month =  | year =  2006| doi =  10.1053/j.semdp.2006.11.002| pmid = 17355088 }}</ref>
*Fatty change without ballooning degeneration is [[steatosis]].
*Typically seen in the context of [[obesity]] or [[alcohol]].


==Microscopic==
==Microscopic==
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DDx:
DDx:
*[[Feathery degeneration]] - has noticable bile.
*[[Feathery degeneration]] - has a similar morphology; however, noticeable (yellow) bile is present.


===Images===
===Images===

Latest revision as of 23:05, 3 January 2016

Ballooning degeneration. H&E stain. (WC)

Ballooning degeneration is a histomorphologic change seen in liver pathology. It is indicative of steatohepatitis.[1]

General

Microscopic

Features:

  • Central nucleus.
    • "Fat cells" have peripheral nucleus.
  • Cytoplasm cleared with "whisps" or cobbwebs.
  • Large relative to normal hepatocyte.
    • 2-3X normal size.[3]

Notes:

DDx:

Images

www:

See also

References

  1. Liangpunsakul, S; Chalasani, N (Dec 2003). "Treatment of Nonalcoholic Fatty Liver Disease.". Curr Treat Options Gastroenterol 6 (6): 455-463. PMID 14585234.
  2. Yip, WW; Burt, AD (2006). "Alcoholic liver disease.". Semin Diagn Pathol 23 (3-4): 149–60. doi:10.1053/j.semdp.2006.11.002. PMID 17355088.
  3. Guindi, M. 16 September 2009.