Difference between revisions of "Atypical lung carcinoid tumour"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Atypical lung carcinoid -- intermed mag.jpg
| Width      =
| Caption    = Atypical lung carcinoid tumour. [[H&E stain]].
| Synonyms  = atypical carcinoid, atypical lung carcinoid, atypical pulmonary carcinoid
| Micro      =
| Subtypes  =
| LMDDx      = [[small cell carcinoma of the lung]], [[carcinoid lung tumour]], [[pulmonary carcinoid tumourlet]], [[lung adenocarcinoma]], metastatic [[small cell carcinoma]]
| Stains    =
| IHC        = Ki-67 ~17% (range 10-26%)
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[lung]] - see ''[[lung tumours]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = moderate; poor vis-à-vis typical carcinoid
| Other      =
| ClinDDx    = other [[lung tumours]]
| Tx        = surgical resection +/-chemotherapy
}}
'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours|lung tumour]] with a poor outcome.
'''Atypical carcinoid lung tumour''', also '''atypical carcinoid''', is an uncommon [[lung tumours|lung tumour]] with a poor outcome.


==General==
==General==
*Approximately 20% of lung carcinoids.<ref name=pmid20888248>{{Cite journal  | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref>
*Approximately 20% of [[lung carcinoid]]s.<ref name=pmid20888248>{{Cite journal  | last1 = Naalsund | first1 = A. | last2 = Rostad | first2 = H. | last3 = Strøm | first3 = EH. | last4 = Lund | first4 = MB. | last5 = Strand | first5 = TE. | title = Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study. | journal = Eur J Cardiothorac Surg | volume = 39 | issue = 4 | pages = 565-9 | month = Apr | year = 2011 | doi = 10.1016/j.ejcts.2010.08.036 | PMID = 20888248 }}</ref>
 
Prognosis:
*Significantly worse than for typical carcinoids; in one series,<ref name=pmid26195112>{{Cite journal  | last1 = Ayadi-Kaddour | first1 = A. | last2 = Marghli | first2 = A. | last3 = Zairi | first3 = S. | last4 = Zribi | first4 = H. | last5 = Ismail | first5 = O. | last6 = Braham | first6 = E. | last7 = Hantous-Zannad | first7 = S. | last8 = Kilani | first8 = T. | last9 = El Mezni | first9 = F. | title = [Bronchopulmonary carcinoid tumors: Tunisian experience with 115 surgically treated cases]. | journal = Rev Pneumol Clin | volume = 71 | issue = 6 | pages = 319-26 | month = Dec | year = 2015 | doi = 10.1016/j.pneumo.2015.04.003 | PMID = 26195112 }}</ref> the five year survival was 95% and 45% for typical carcinoid and atypical carcinoid respectively.
 
Treatment:
*Surgery for diagnosis and treatment.
*Chemotherapy for advanced/metastatic disease.<ref name=pmid25218177>{{Cite journal  | last1 = Chong | first1 = CR. | last2 = Wirth | first2 = LJ. | last3 = Nishino | first3 = M. | last4 = Chen | first4 = AB. | last5 = Sholl | first5 = LM. | last6 = Kulke | first6 = MH. | last7 = McNamee | first7 = CJ. | last8 = Jänne | first8 = PA. | last9 = Johnson | first9 = BE. | title = Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors. | journal = Lung Cancer | volume = 86 | issue = 2 | pages = 241-6 | month = Nov | year = 2014 | doi = 10.1016/j.lungcan.2014.08.012 | PMID = 25218177 }}</ref>


==Microscopic==
==Microscopic==
Line 15: Line 54:
*[[Typical carcinoid lung tumour]].
*[[Typical carcinoid lung tumour]].
*[[Small cell carcinoma of the lung]].
*[[Small cell carcinoma of the lung]].
*Metastatic [[small cell carcinoma]].
*[[Lung adenocarcinoma]].
===Images===
<gallery>
Image: Atypical lung carcinoid -- low mag.jpg | ALC - low mag.
Image: Atypical lung carcinoid -- intermed mag.jpg | ALC - intermed. mag.
Image: Atypical lung carcinoid -- high mag.jpg | ALC - high mag.
Image: Atypical lung carcinoid -- very high mag.jpg | ALC - very high mag.
Image: Atypical lung carcinoid - alt -- high mag.jpg | ALC - high mag.
Image: Atypical lung carcinoid - alt -- very high mag.jpg | ALC - very high mag.
Image: Atypical lung carcinoid - alt -- extremely high mag.jpg | ALC - extremely high mag.
</gallery>


==IHC==
==IHC==

Latest revision as of 05:45, 20 April 2016

Atypical lung carcinoid tumour
Diagnosis in short

Atypical lung carcinoid tumour. H&E stain.
Synonyms atypical carcinoid, atypical lung carcinoid, atypical pulmonary carcinoid
LM DDx small cell carcinoma of the lung, carcinoid lung tumour, pulmonary carcinoid tumourlet, lung adenocarcinoma, metastatic small cell carcinoma
IHC Ki-67 ~17% (range 10-26%)
Site lung - see lung tumours
Prognosis moderate; poor vis-à-vis typical carcinoid
Clin. DDx other lung tumours
Treatment surgical resection +/-chemotherapy

Atypical carcinoid lung tumour, also atypical carcinoid, is an uncommon lung tumour with a poor outcome.

General

Prognosis:

  • Significantly worse than for typical carcinoids; in one series,[2] the five year survival was 95% and 45% for typical carcinoid and atypical carcinoid respectively.

Treatment:

  • Surgery for diagnosis and treatment.
  • Chemotherapy for advanced/metastatic disease.[3]

Microscopic

Features:[4]

  • Nests of cells.
    • Stippled chromatin.
    • Mild-to-moderate amount of cytoplasm.
  • No necrosis/focal necrosis.
  • Moderate mitotic rate (2-10/HPF - definition suffers from HPFitis).

DDx:

Images

  • ALC - low mag.

  • ALC - intermed. mag.

  • ALC - high mag.

  • ALC - very high mag.

  • ALC - high mag.

  • ALC - very high mag.

  • ALC - extremely high mag.

IHC

  • Ki-67 ~17% (range 10-26%).[5]

Note:

  • Typical carcinoid is considerably lower ~2% (range 0-7%) and large cell neuroendocrine considerable higher ~81% (range 63-92%).[5]

See also

References

  1. ↑ Naalsund, A.; Rostad, H.; Strøm, EH.; Lund, MB.; Strand, TE. (Apr 2011). "Carcinoid lung tumors--incidence, treatment and outcomes: a population-based study.". Eur J Cardiothorac Surg 39 (4): 565-9. doi:10.1016/j.ejcts.2010.08.036. PMID 20888248.
  2. ↑ Ayadi-Kaddour, A.; Marghli, A.; Zairi, S.; Zribi, H.; Ismail, O.; Braham, E.; Hantous-Zannad, S.; Kilani, T. et al. (Dec 2015). "[Bronchopulmonary carcinoid tumors: Tunisian experience with 115 surgically treated cases].". Rev Pneumol Clin 71 (6): 319-26. doi:10.1016/j.pneumo.2015.04.003. PMID 26195112.
  3. ↑ Chong, CR.; Wirth, LJ.; Nishino, M.; Chen, AB.; Sholl, LM.; Kulke, MH.; McNamee, CJ.; Jänne, PA. et al. (Nov 2014). "Chemotherapy for locally advanced and metastatic pulmonary carcinoid tumors.". Lung Cancer 86 (2): 241-6. doi:10.1016/j.lungcan.2014.08.012. PMID 25218177.
  4. ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 115. ISBN 978-0781765275.
  5. ↑ 5.0 5.1 Liu, SZ.; Staats, PN.; Goicochea, L.; Alexiev, BA.; Shah, N.; Dixon, R.; Burke, AP. (2014). "Automated quantification of Ki-67 proliferative index of excised neuroendocrine tumors of the lung.". Diagn Pathol 9: 174. doi:10.1186/s13000-014-0174-z. PMID 25318848.
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