Renal oncocytosis: Difference between revisions
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| Caption = | | Caption = | ||
| Synonyms = | | Synonyms = | ||
| Micro = any mixture of oncocytic tumours - see [[hybrid tumour]], [[chromophobe renal cell carcinoma]] and [[renal oncocytoma]] | | Micro = any mixture of oncocytic tumours - see [[hybrid tumour]], [[chromophobe renal cell carcinoma]] (ChRCC) and [[renal oncocytoma]]; "in situ" oncocytic cells (outside of the tumour) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = other [[renal tumours with eosinophilic cytoplasm]] | | LMDDx = other [[renal tumours with eosinophilic cytoplasm]] | ||
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| IHC = characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour | | IHC = characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = +/-gain of chromosome 5, do not typically have chromosomal losses seen in ChRCC | ||
| IF = | | IF = | ||
| Gross = multiple brown kidney nodules (bilateral or unilateral) | | Gross = multiple brown kidney nodules (bilateral or unilateral) | ||
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Features: | Features: | ||
*Any mixture of oncocytic tumours ([[hybrid tumour]], [[chromophobe renal cell carcinoma]], [[renal oncocytoma]]). | *Any mixture of oncocytic tumours ([[hybrid tumour]], [[chromophobe renal cell carcinoma]], [[renal oncocytoma]]). | ||
*"In situ" oncocytic cells (similar to the tumour cells) within renal tubules.<ref name=pmid19636405>{{Cite journal | last1 = Huang | first1 = J. | last2 = Lee | first2 = P. | last3 = Mikami | first3 = Y. | last4 = Melamed | first4 = J. | title = Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis). | journal = Int J Clin Exp Pathol | volume = 2 | issue = 6 | pages = 583-7 | month = | year = 2009 | doi = | PMID = 19636405 }}</ref> | |||
DDx: | DDx: | ||
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*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713448/figure/fig01/ In situ oncocytosis (nih.gov)].<ref name=pmid19636405/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713448/figure/fig02/ In situ oncocytosis (nih.gov)]. | |||
==IHC== | ==IHC== | ||
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==See also== | ==See also== | ||
*[[Renal tumours]]. | *[[Renal tumours]]. | ||
*[[Renal tumours with eosinophilic cytoplasm]]. | |||
==References== | ==References== | ||