Difference between revisions of "Renal oncocytosis"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
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| Caption = | | Caption = | ||
| Synonyms = | | Synonyms = | ||
| Micro = | | Micro = any mixture of oncocytic tumours - see [[hybrid tumour]], [[chromophobe renal cell carcinoma]] (ChRCC) and [[renal oncocytoma]]; "in situ" oncocytic cells (outside of the tumour) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = other [[renal tumours with eosinophilic cytoplasm]] | | LMDDx = other [[renal tumours with eosinophilic cytoplasm]] | ||
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| IHC = characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour | | IHC = characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = +/-gain of chromosome 5, do not typically have chromosomal losses seen in ChRCC | ||
| IF = | | IF = | ||
| Gross = multiple brown kidney nodules (bilateral or unilateral) | | Gross = multiple brown kidney nodules (bilateral or unilateral) | ||
| Grossing = | | Grossing = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]] | ||
| Staging = | | Staging = [[kidney cancer staging]] | ||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | | Site = [[kidney]] - see ''[[kidney tumours]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = [[Birt–Hogg–Dubé syndrome]] | | Syndromes = [[Birt–Hogg–Dubé syndrome]] | ||
| Clinicalhx = | | Clinicalhx = +/-[[chronic renal failure]] and hemodialysis | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = rare | | Prevalence = rare | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = multiple renal tumours | | Rads = multiple renal tumours (unilateral or bilateral) | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = | ||
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*Rare. | *Rare. | ||
*May be seen in the context of [[Birt–Hogg–Dubé syndrome]] or [[chronic renal failure]] or may be sporadic.<ref name=pmid23018240/> | *May be seen in the context of [[Birt–Hogg–Dubé syndrome]] or [[chronic renal failure]] or may be sporadic.<ref name=pmid23018240/> | ||
**Chronic renal failure seen in 50% of cases in one series.<ref name=pmid21239013>{{Cite journal | last1 = Adamy | first1 = A. | last2 = Lowrance | first2 = WT. | last3 = Yee | first3 = DS. | last4 = Chong | first4 = KT. | last5 = Bernstein | first5 = M. | last6 = Tickoo | first6 = SK. | last7 = Coleman | first7 = JA. | last8 = Russo | first8 = P. | title = Renal oncocytosis: management and clinical outcomes. | journal = J Urol | volume = 185 | issue = 3 | pages = 795-801 | month = Mar | year = 2011 | doi = 10.1016/j.juro.2010.10.068 | PMID = 21239013 }}</ref> | |||
==Gross== | ==Gross== | ||
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Features: | Features: | ||
*Any mixture of oncocytic tumours ([[hybrid tumour]], [[chromophobe renal cell carcinoma]], [[renal oncocytoma]]). | *Any mixture of oncocytic tumours ([[hybrid tumour]], [[chromophobe renal cell carcinoma]], [[renal oncocytoma]]). | ||
*"In situ" oncocytic cells (similar to the tumour cells) within renal tubules.<ref name=pmid19636405>{{Cite journal | last1 = Huang | first1 = J. | last2 = Lee | first2 = P. | last3 = Mikami | first3 = Y. | last4 = Melamed | first4 = J. | title = Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis). | journal = Int J Clin Exp Pathol | volume = 2 | issue = 6 | pages = 583-7 | month = | year = 2009 | doi = | PMID = 19636405 }}</ref> | |||
DDx: | DDx: | ||
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*[[Renal oncocytoma]]. | *[[Renal oncocytoma]]. | ||
*Other [[renal tumours with eosinophilic cytoplasm]]. | *Other [[renal tumours with eosinophilic cytoplasm]]. | ||
===Images=== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713448/figure/fig01/ In situ oncocytosis (nih.gov)].<ref name=pmid19636405/> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713448/figure/fig02/ In situ oncocytosis (nih.gov)]. | |||
==IHC== | ==IHC== | ||
*Characteristic of the histologic appearance.<ref name=pmid23018240/> | *Characteristic of the histologic appearance.<ref name=pmid23018240/> | ||
*Stain like [[renal oncocytoma]]s, [[chromophobe renal cell carcinoma]]s and [[hybrid tumour]]s. | *Stain like [[renal oncocytoma]]s, [[chromophobe renal cell carcinoma]]s and [[hybrid tumour]]s. | ||
==Molecular== | |||
*Scant data suggests chromosomal changes are seen that are different than those of [[ChRCC]] and [[oncocytoma]].<ref name=pmid20305535>{{Cite journal | last1 = Gobbo | first1 = S. | last2 = Eble | first2 = JN. | last3 = Delahunt | first3 = B. | last4 = Grignon | first4 = DJ. | last5 = Samaratunga | first5 = H. | last6 = Martignoni | first6 = G. | last7 = Zhang | first7 = S. | last8 = Wang | first8 = M. | last9 = Brunelli | first9 = M. | title = Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles. | journal = Am J Surg Pathol | volume = 34 | issue = 5 | pages = 620-6 | month = May | year = 2010 | doi = 10.1097/PAS.0b013e3181d73293 | PMID = 20305535 }}</ref> | |||
**Do not have the chromosomal losses typical of ChRCC. | |||
**May have gains in chromosome 5. | |||
Note: | |||
*ChRCC typically has loss of chromosomes: 1, 2, 6, 10, 13, 17, 21.<ref name=Ref_WMSP292>{{Ref WMSP|292}}</ref> | |||
==See also== | ==See also== | ||
*[[Renal tumours]]. | *[[Renal tumours]]. | ||
*[[Renal tumours with eosinophilic cytoplasm]]. | |||
==References== | ==References== | ||
Latest revision as of 16:02, 6 December 2015
| Renal oncocytosis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | any mixture of oncocytic tumours - see hybrid tumour, chromophobe renal cell carcinoma (ChRCC) and renal oncocytoma; "in situ" oncocytic cells (outside of the tumour) |
| LM DDx | other renal tumours with eosinophilic cytoplasm |
| IHC | characteristic of the histologic appearance - stain like oncocytoma, ChRCC and hybrid tumour |
| Molecular | +/-gain of chromosome 5, do not typically have chromosomal losses seen in ChRCC |
| Gross | multiple brown kidney nodules (bilateral or unilateral) |
| Grossing notes | total nephrectomy for tumour grossing, partial nephrectomy grossing |
| Staging | kidney cancer staging |
| Site | kidney - see kidney tumours |
|
| |
| Syndromes | Birt–Hogg–Dubé syndrome |
|
| |
| Clinical history | +/-chronic renal failure and hemodialysis |
| Prevalence | rare |
| Radiology | multiple renal tumours (unilateral or bilateral) |
| Clin. DDx | metastatic disease, multifocal renal cell carcinoma |
Renal oncocytosis is the presence of multiple oncocytic lesions within the kidney.[1]
General
- Rare.
- May be seen in the context of Birt–Hogg–Dubé syndrome or chronic renal failure or may be sporadic.[1]
- Chronic renal failure seen in 50% of cases in one series.[2]
Gross
- Multiple (unilateral or bilateral) brown-coloured nodules.[1]
Microscopic
Features:
- Any mixture of oncocytic tumours (hybrid tumour, chromophobe renal cell carcinoma, renal oncocytoma).
- "In situ" oncocytic cells (similar to the tumour cells) within renal tubules.[3]
DDx:
- Hybrid tumour.
- Chromophobe renal cell carcinoma.
- Renal oncocytoma.
- Other renal tumours with eosinophilic cytoplasm.
Images
IHC
- Characteristic of the histologic appearance.[1]
- Stain like renal oncocytomas, chromophobe renal cell carcinomas and hybrid tumours.
Molecular
- Scant data suggests chromosomal changes are seen that are different than those of ChRCC and oncocytoma.[4]
- Do not have the chromosomal losses typical of ChRCC.
- May have gains in chromosome 5.
Note:
- ChRCC typically has loss of chromosomes: 1, 2, 6, 10, 13, 17, 21.[5]
See also
References
- ↑ 1.0 1.1 1.2 1.3 Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
- ↑ Adamy, A.; Lowrance, WT.; Yee, DS.; Chong, KT.; Bernstein, M.; Tickoo, SK.; Coleman, JA.; Russo, P. (Mar 2011). "Renal oncocytosis: management and clinical outcomes.". J Urol 185 (3): 795-801. doi:10.1016/j.juro.2010.10.068. PMID 21239013.
- ↑ 3.0 3.1 Huang, J.; Lee, P.; Mikami, Y.; Melamed, J. (2009). "Dysplastic ("in-situ") Lesions in multofocal renal oncocytomas (oncocytosis).". Int J Clin Exp Pathol 2 (6): 583-7. PMID 19636405.
- ↑ Gobbo, S.; Eble, JN.; Delahunt, B.; Grignon, DJ.; Samaratunga, H.; Martignoni, G.; Zhang, S.; Wang, M. et al. (May 2010). "Renal cell neoplasms of oncocytosis have distinct morphologic, immunohistochemical, and cytogenetic profiles.". Am J Surg Pathol 34 (5): 620-6. doi:10.1097/PAS.0b013e3181d73293. PMID 20305535.
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 292. ISBN 978-0781765275.