Difference between revisions of "Urothelial carcinoma-like prostatic carcinoma"

From Libre Pathology
Jump to navigation Jump to search
(create)
 
 
(12 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Urothelial carcinoma-like prostatic carcinoma''' is a [[prostatic carcinoma]] that histologically mimics [[urothelial carcinoma]].   
'''Urothelial carcinoma-like prostatic carcinoma''', abbreviated '''UCLPC''', is a [[prostatic carcinoma]] that histologically mimics [[urothelial carcinoma]].   


It is not a formally recognized type of [[prostate cancer]].
It is not a formally recognized type of [[prostate cancer]].
''Prostatic carcinoma with pseudopapillae'' and ''prostatic adenocarcinoma with pseudopapillae'' redirect here.


==General==
==General==
*Uncommon.
*Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
*Relative proximity of the [[urinary bladder]] and [[prostate]] results in clinical scenarios where the primary site is not readily apparent.
 
Clinical:
*History of urothelial carcinoma lacking.
*+/-Elevated [[PSA]].
 
==Gross==
Classic tumour locations:
*Bladder neck.
*Trigone/base of bladder.
*Prostatic [[urethra]].


==Microscopic==
==Microscopic==
Features:
Features:
*Large epithelioid cells with prominent nucleoli.
*Large epithelioid cells with [[prominent nucleoli]] and (usually) moderate [[nuclear pleomorphism]].
*+/-Papillary structures (pseudopapillae).
*+/-Papillary structures (pseudopapillae).<ref name=pmid24503758/>
*+/-Features suggestive of prostatic carcinoma - cribriforming glands ''or'' poorly formed glandular structures.
*+/-Features suggestive of prostatic carcinoma - cribriforming glands ''or'' poorly formed glandular structures.


Line 16: Line 29:
**[[High grade papillary urothelial carcinoma]].
**[[High grade papillary urothelial carcinoma]].
*[[Collision tumour]] consisting of [[urothelial carcinoma]] and [[prostatic carcinoma]].
*[[Collision tumour]] consisting of [[urothelial carcinoma]] and [[prostatic carcinoma]].
*Other [[carcinoma]]s.


===Images===
===Images===
Line 58: Line 72:


[[Category:Genitourinary pathology]]
[[Category:Genitourinary pathology]]
[[Category:Prostate carcinoma]]

Latest revision as of 06:14, 20 April 2016

Urothelial carcinoma-like prostatic carcinoma, abbreviated UCLPC, is a prostatic carcinoma that histologically mimics urothelial carcinoma.

It is not a formally recognized type of prostate cancer.

Prostatic carcinoma with pseudopapillae and prostatic adenocarcinoma with pseudopapillae redirect here.

General

  • Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
  • Relative proximity of the urinary bladder and prostate results in clinical scenarios where the primary site is not readily apparent.

Clinical:

  • History of urothelial carcinoma lacking.
  • +/-Elevated PSA.

Gross

Classic tumour locations:

  • Bladder neck.
  • Trigone/base of bladder.
  • Prostatic urethra.

Microscopic

Features:

  • Large epithelioid cells with prominent nucleoli and (usually) moderate nuclear pleomorphism.
  • +/-Papillary structures (pseudopapillae).[1]
  • +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.

DDx:

Images

  • UCLPC - very low mag.

  • UCLPC - low mag.

  • UCLPC - low mag.

  • UCLPC - intermed. mag.

  • UCLPC - intermed. mag.

  • UCLPC - high mag.

  • UCLPC - high mag.

  • UCLPC - very high mag.

  • UCLPC - very high mag.

  • PC - intermed. mag.

  • PC - high mag.

IHC

Features:[1]

  • GATA3 -ve.
  • NKX3.1 +ve.

Images

  • UCLPC - NKX3.1 - intermed. mag.

  • UCLPC - AMACR-CK5/6 - very low mag.

  • UCLPC - AMACR-CK5/6 - intermed. mag.

  • UCLPC - GATA3 - intermed. mag.

  • Urothelium - GATA3 - high mag.

See also

References

  1. ↑ 1.0 1.1 Gordetsky, J.; Epstein, JI. (Jul 2014). "Pseudopapillary features in prostatic adenocarcinoma mimicking urothelial carcinoma: a diagnostic pitfall.". Am J Surg Pathol 38 (7): 941-5. doi:10.1097/PAS.0000000000000178. PMID 24503758.
Retrieved from "https://librepathology.org/w/index.php?title=Urothelial_carcinoma-like_prostatic_carcinoma&oldid=43809"