Difference between revisions of "Glypican 3"

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'''Glypican 3''' is a common [[immunostain]] used in [[gastrointestinal pathology]] and [[genituorinary pathology]].
'''Glypican 3''', abbreviated '''GPC3''',<ref>{{OMIM|300037}}</ref> is a common [[immunostain]] used in [[gastrointestinal pathology]] and [[genitourinary pathology]].


==Positive==
==Positive==
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*[[Malignant melanoma]].<ref name=pmid25896897/>
*[[Malignant melanoma]].<ref name=pmid25896897/>
*[[Squamous cell carcinoma of the lung]].<ref name=pmid25896897/>
*[[Squamous cell carcinoma of the lung]].<ref name=pmid25896897/>
**Uncommon in adenocarcinoma of the lung ~3% of cases.<ref name=pmid26345955>{{Cite journal  | last1 = Yu | first1 = X. | last2 = Li | first2 = Y. | last3 = Chen | first3 = SW. | last4 = Shi | first4 = Y. | last5 = Xu | first5 = F. | title = Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance. | journal = Genet Mol Res | volume = 14 | issue = 3 | pages = 10185-92 | month = Aug | year = 2015 | doi = 10.4238/2015.August.28.2 | PMID = 26345955 }}</ref>
*[[Yolk sac tumour]].
*[[Yolk sac tumour]].
**More sensitive than [[alpha-fetoprotein]] (AFP).<ref name=pmid20438407>{{Cite journal  | last1 = Emerson | first1 = RE. | last2 = Ulbright | first2 = TM. | title = Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers. | journal = Pathology | volume = 42 | issue = 4 | pages = 344-55 | month = Jun | year = 2010 | doi = 10.3109/00313021003767355 | PMID = 20438407 }}</ref>


===Images===
===Images===
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414302/figure/Fig1/ Glypican 3 in UCC (nih.gov)].<ref name=pmid25896897/>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414302/figure/Fig1/ Glypican 3 in UCC (nih.gov)].<ref name=pmid25896897/>
==Positive or negative==
*[[Choriocarcinoma]].


==See also==
==See also==

Latest revision as of 16:29, 7 December 2017

Glypican 3, abbreviated GPC3,[1] is a common immunostain used in gastrointestinal pathology and genitourinary pathology.

Positive

Images

Positive or negative

See also

References

  1. Online 'Mendelian Inheritance in Man' (OMIM) 300037
  2. 2.0 2.1 2.2 2.3 Aydin, O.; Yildiz, L.; Baris, S.; Dundar, C.; Karagoz, F. (2015). "Expression of Glypican 3 in low and high grade urothelial carcinomas.". Diagn Pathol 10: 34. doi:10.1186/s13000-015-0266-4. PMID 25896897.
  3. Yu, X.; Li, Y.; Chen, SW.; Shi, Y.; Xu, F. (Aug 2015). "Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance.". Genet Mol Res 14 (3): 10185-92. doi:10.4238/2015.August.28.2. PMID 26345955.
  4. Emerson, RE.; Ulbright, TM. (Jun 2010). "Intratubular germ cell neoplasia of the testis and its associated cancers: the use of novel biomarkers.". Pathology 42 (4): 344-55. doi:10.3109/00313021003767355. PMID 20438407.