Difference between revisions of "Carcinosarcoma"
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[[Image:Carcinosarcoma - high mag.jpg|thumb|right|Micrograph showing a carcinosarcoma. [[H&E stain]].]] | |||
'''Carcinosarcoma''' is a tumour with a malignant epithelial component ([[carcinoma]]) and a malignant mesenchymal component ([[sarcoma]]), based on the histomorphology. | '''Carcinosarcoma''' is a tumour with a malignant epithelial component ([[carcinoma]]) and a malignant mesenchymal component ([[sarcoma]]), based on the histomorphology. | ||
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*Fallopian tube carcinosarcoma. | *Fallopian tube carcinosarcoma. | ||
==Relation to | ==Relation of carcinosarcoma to metaplastic carcinoma and sarcomatoid carcinoma== | ||
''Carcinosarcoma'' implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously. | ''Carcinosarcoma'' implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously. | ||
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# [[Metaplastic carcinoma]] - implies the tumour arose from epithelial cells that had undergone a (morphologic) transformation (metaplasia). | # [[Metaplastic carcinoma]] - implies the tumour arose from epithelial cells that had undergone a (morphologic) transformation (metaplasia). | ||
Uterine carcinosarcomas are generally considered [[metaplastic carcinoma]]s.<ref name=pmid25805398>{{Cite journal | last1 = Cantrell | first1 = LA. | last2 = Blank | first2 = SV. | last3 = Duska | first3 = LR. | title = Uterine carcinosarcoma: A review of the literature. | journal = Gynecol Oncol | volume = 137 | issue = 3 | pages = 581-588 | month = Jun | year = 2015 | doi = 10.1016/j.ygyno.2015.03.041 | PMID = 25805398 }}</ref><ref name=pmid25468677>{{Cite journal | last1 = Artioli | first1 = G. | last2 = Wabersich | first2 = J. | last3 = Ludwig | first3 = K. | last4 = Gardiman | first4 = MP. | last5 = Borgato | first5 = L. | last6 = Garbin | first6 = F. | title = Rare uterine cancer: carcinosarcomas. Review from histology to treatment. | journal = Crit Rev Oncol Hematol | volume = 94 | issue = 1 | pages = 98-104 | month = Apr | year = 2015 | doi = 10.1016/j.critrevonc.2014.10.013 | PMID = 25468677 }}</ref> They typically metastasize as [[carcinoma]]s,<ref name=pmid21309261>{{Cite journal | last1 = Lopez-Garcia | first1 = MA. | last2 = Palacios | first2 = J. | title = Pathologic and molecular features of uterine carcinosarcomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 274-86 | month = Nov | year = 2010 | doi = | PMID = 21309261 }}</ref> | Uterine carcinosarcomas are generally considered [[metaplastic carcinoma]]s.<ref name=pmid25805398>{{Cite journal | last1 = Cantrell | first1 = LA. | last2 = Blank | first2 = SV. | last3 = Duska | first3 = LR. | title = Uterine carcinosarcoma: A review of the literature. | journal = Gynecol Oncol | volume = 137 | issue = 3 | pages = 581-588 | month = Jun | year = 2015 | doi = 10.1016/j.ygyno.2015.03.041 | PMID = 25805398 }}</ref><ref name=pmid25468677>{{Cite journal | last1 = Artioli | first1 = G. | last2 = Wabersich | first2 = J. | last3 = Ludwig | first3 = K. | last4 = Gardiman | first4 = MP. | last5 = Borgato | first5 = L. | last6 = Garbin | first6 = F. | title = Rare uterine cancer: carcinosarcomas. Review from histology to treatment. | journal = Crit Rev Oncol Hematol | volume = 94 | issue = 1 | pages = 98-104 | month = Apr | year = 2015 | doi = 10.1016/j.critrevonc.2014.10.013 | PMID = 25468677 }}</ref> They typically metastasize as [[carcinoma]]s,<ref name=pmid21309261>{{Cite journal | last1 = Lopez-Garcia | first1 = MA. | last2 = Palacios | first2 = J. | title = Pathologic and molecular features of uterine carcinosarcomas. | journal = Semin Diagn Pathol | volume = 27 | issue = 4 | pages = 274-86 | month = Nov | year = 2010 | doi = | PMID = 21309261 }}</ref> and putatively arise from epithelial cells (only). | ||
and putatively arise from epithelial cells (only). | |||
The term ''carcinosarcoma'' is from the morphologic era of pathology;{{fact}} it precedes the modern battery of molecular tests and [[immunohistochemistry]]. | The term ''carcinosarcoma'' is from the morphologic era of pathology;{{fact}} it precedes the modern battery of molecular tests and [[immunohistochemistry]]. | ||
Latest revision as of 05:42, 5 August 2015
Micrograph showing a carcinosarcoma. H&E stain.
Carcinosarcoma is a tumour with a malignant epithelial component (carcinoma) and a malignant mesenchymal component (sarcoma), based on the histomorphology.
They can arise in a number of sites:
- Uterine carcinosarcoma (most common).
- Ovarian carcinosarcoma.
- Fallopian tube carcinosarcoma.
Relation of carcinosarcoma to metaplastic carcinoma and sarcomatoid carcinoma
Carcinosarcoma implies that the tumour arose from mesenchymal cells and epithelial cells simultaneously.
This is in contradistinction to:
- Sarcomatoid carcinoma - implies the tumour arose from epithelial cells only and is sarcoma-like (morphologically), and
- Metaplastic carcinoma - implies the tumour arose from epithelial cells that had undergone a (morphologic) transformation (metaplasia).
Uterine carcinosarcomas are generally considered metaplastic carcinomas.[1][2] They typically metastasize as carcinomas,[3] and putatively arise from epithelial cells (only).
The term carcinosarcoma is from the morphologic era of pathology;[citation needed] it precedes the modern battery of molecular tests and immunohistochemistry.
See also
References
- ↑ Cantrell, LA.; Blank, SV.; Duska, LR. (Jun 2015). "Uterine carcinosarcoma: A review of the literature.". Gynecol Oncol 137 (3): 581-588. doi:10.1016/j.ygyno.2015.03.041. PMID 25805398.
- ↑ Artioli, G.; Wabersich, J.; Ludwig, K.; Gardiman, MP.; Borgato, L.; Garbin, F. (Apr 2015). "Rare uterine cancer: carcinosarcomas. Review from histology to treatment.". Crit Rev Oncol Hematol 94 (1): 98-104. doi:10.1016/j.critrevonc.2014.10.013. PMID 25468677.
- ↑ Lopez-Garcia, MA.; Palacios, J. (Nov 2010). "Pathologic and molecular features of uterine carcinosarcomas.". Semin Diagn Pathol 27 (4): 274-86. PMID 21309261.
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