Difference between revisions of "Ganglioneuroma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Adrenal Ganglioneuroma MP2 14BR***.jpg
| Width      =
| Caption    = Adrenal Ganglioneuroma. [[H&E stain]].
| Synonyms  =
| Micro      = ganglion cells (large cells with large nucleus and prominent nucleolus), disordered fibrinous-like material, eosinophilic granular bodies
| Subtypes  =
| LMDDx      = [[ganglioneuroblastoma]]
| Stains    =
| IHC        = synaptophysin +ve, S-100 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      = solid, firm, white
| Grossing  =
| Site      = usually adrenal or retroperitoneal, paraspinal
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Ganglioneuroma''' is a benign neuroblasic tumour. It is also known as '''ganglioma'''.<ref>URL: [http://medical-dictionary.thefreedictionary.com/ganglioma http://medical-dictionary.thefreedictionary.com/ganglioma]. Accessed on: 8 November 2010.</ref>
'''Ganglioneuroma''' is a benign neuroblasic tumour. It is also known as '''ganglioma'''.<ref>URL: [http://medical-dictionary.thefreedictionary.com/ganglioma http://medical-dictionary.thefreedictionary.com/ganglioma]. Accessed on: 8 November 2010.</ref>


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<gallery>
<gallery>
Image:Adrenal_ganglioneuroma_02.JPG | Adrenal ganglioneuroma. (WC)
Image:Adrenal_ganglioneuroma_02.JPG | Adrenal ganglioneuroma. (WC)
File:Ganglioneuroma.jpg | Abdominal Ganglioneuroma, HE stain. (WC/jensflorian)
 
File:Retroperitoneum Ganglioneuroma (4165776371).jpg| Retroperitoneal Ganglioneuroma. (Ed Uthman)
File:Adrenal Ganglioneuroma MP2 CTR.jpg | Bipolar ganglion cell in adrenal Ganglioneuroma (WC/Sarahkayb)
File:Adrenal Ganglioneuroma LP 14BR***.jpg | Adrenal Ganglioneuroma, low magnification (WC/Sarahkayb)
File:Adrenal Ganglioneuroma MP2 14BR***.jpg | Adrenal Ganglioneuroma, high magnification (WC/Sarahkayb)
File:Adrenal Ganglioneuroma Syn 14BR***.jpg | Adrenal Ganglioneuroma, Synaptophysin (WC/Sarahkayb)
File:Ganglioneuroma (1).jpg | Histopathological image of ganglioneuroma in the posterior wall of pharynx. (WC/KGH)


</gallery>
</gallery>
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*[http://www.webpathology.com/image.asp?case=84&n=1 Ganglioneuroma (webpathology.com)].
*[http://www.webpathology.com/image.asp?case=84&n=1 Ganglioneuroma (webpathology.com)].


===Microscopic===
==Microscopic==
Features:
Features:
*Ganglion cells - '''key feature'''.
*Ganglion cells - '''key feature'''.
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Image:Adrenal Ganglioneurona 2 MP2 PA.JPG|Adrenal Ganglioneuroma - Medium power (SKB)
Image:Adrenal Ganglioneurona 2 MP2 PA.JPG|Adrenal Ganglioneuroma - Medium power (SKB)
Image:Adrenal Ganglioneuroma MP PA.JPG|Adrenal Ganglioneuroma - Medium power (SKB)
Image:Adrenal Ganglioneuroma MP PA.JPG|Adrenal Ganglioneuroma - Medium power (SKB)
File:Ganglioneuroma.jpg | Abdominal Ganglioneuroma, HE stain. (WC/jensflorian)
File:Retroperitoneum Ganglioneuroma (4165776371).jpg| Retroperitoneal Ganglioneuroma. (Ed Uthman)
File:Ganglioneuroma (1).jpg | Histopathological image of ganglioneuroma in the posterior wall of pharynx. (WC/KGH)
File:Ganglioneuroma_-_high_mag.jpg | Ganglioneuroma in colonic biopsy (WC/Nephron)
File:Ganglioneuroma_-_very_high_mag.jpg| Ganglioneuroma in colonic biopsy, high mag (WC/Nephron)
</gallery>
</gallery>
www:
www:
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*Spindle cells: S-100 +ve.
*Spindle cells: S-100 +ve.
*Ganglion cells: NSE, synaptophysin, NF.
*Ganglion cells: NSE, synaptophysin, NF.
==Sign out==
<pre>
Paraspinal Lesion, Right, Core Biopsy:
- Ganglioneuroma.
Comment:
The lesion stains as follows:
POSITIVE: S-100 & vimentin (stroma, ganglion cells), synaptophysin (ganglion cells only).
NEGATIVE: AE1/AE3, CD34.
PROLIFERATION (Ki-67): <1% of cells.
</pre>


==See also==
==See also==

Latest revision as of 00:29, 5 May 2016

Ganglioneuroma
Diagnosis in short

Adrenal Ganglioneuroma. H&E stain.

LM ganglion cells (large cells with large nucleus and prominent nucleolus), disordered fibrinous-like material, eosinophilic granular bodies
LM DDx ganglioneuroblastoma
IHC synaptophysin +ve, S-100 +ve
Gross solid, firm, white
Site usually adrenal or retroperitoneal, paraspinal

Prevalence uncommon
Prognosis good

Ganglioneuroma is a benign neuroblasic tumour. It is also known as ganglioma.[1]

It should not to be confused with ganglioglioma.

General

Classification:

Gross

  • Solid.
  • White.
  • Firm.
  • Well-circumscribed.
  • May be nodular.

Images

www:

Microscopic

Features:

  • Ganglion cells - key feature.
    • Large cells with large nucleus.
      • Prominent nucleolus.
  • Disordered fibrinous-like material.
  • Eosinophilic granular bodies.[3]

See: adrenal ganglioneuroma, colonic ganglioneuroma.

Images

www:

IHC

Features:[4]

  • Spindle cells: S-100 +ve.
  • Ganglion cells: NSE, synaptophysin, NF.

Sign out

Paraspinal Lesion, Right, Core Biopsy:
- Ganglioneuroma.

Comment:
The lesion stains as follows:
POSITIVE: S-100 & vimentin (stroma, ganglion cells), synaptophysin (ganglion cells only).
NEGATIVE: AE1/AE3, CD34.
PROLIFERATION (Ki-67): <1% of cells.

See also

References

  1. URL: http://medical-dictionary.thefreedictionary.com/ganglioma. Accessed on: 8 November 2010.
  2. Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B (July 1999). "Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee". Cancer 86 (2): 349–63. PMID 10421272.
  3. R. Kiehl. 8 November 2010.
  4. Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 217. ISBN 978-0443066573.