Invasive cribriform carcinoma of the breast: Difference between revisions
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| Micro = cribriform architecture, stromal desmoplasia, +/-tubular component | | Micro = cribriform architecture, stromal desmoplasia, +/-tubular component | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]] | | LMDDx = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]]), [[adenoid cystic carcinoma of the breast]] | ||
| Stains = | | Stains = | ||
| IHC = ER +ve, PR +ve, HER2 -ve | | IHC = ER +ve, PR +ve, HER2 -ve | ||
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid23412348/> | ||
*Cribriform architecture. | *[[Cribriform]] (or sieve-like) architecture. | ||
*[[Desmoplastic stroma]]. | *[[Desmoplastic stroma]]. | ||
*+/-[[Tubular carcinoma of the breast|Tubular]] component. | *+/-[[Tubular carcinoma of the breast|Tubular]] component. | ||
Notes: | |||
*Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month = | year = 2013 | doi = | PMID = 23412348 }}</ref> | *Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month = | year = 2013 | doi = | PMID = 23412348 | PMC = 3563205}}</ref> | ||
*Low or intermediate Nottingham grade. | |||
DDx: | DDx: | ||
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*[[Tubular carcinoma of the breast]]. | *[[Tubular carcinoma of the breast]]. | ||
*[[Invasive ductal carcinoma of the breast]] with cribriform component. | *[[Invasive ductal carcinoma of the breast]] with cribriform component. | ||
*[[Adenoid cystic carcinoma of the breast]]. | |||
===Images=== | ===Images=== | ||