Invasive cribriform carcinoma of the breast: Difference between revisions

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Breast CribriformCarcinoma MP SNP.jpg
| Width      =
| Caption    = Invasive cribriform carcinoma of the breast. [[H&E stain]].
| Synonyms  =
| Micro      = cribriform architecture, stromal desmoplasia, +/-tubular component
| Subtypes  =
| LMDDx      = [[tubular carcinoma of the breast|tubular carcinoma]], cribriform [[DCIS]], mixed tumour (e.g. ICC with [[invasive ductal carcinoma of the breast|IDC]]), [[adenoid cystic carcinoma of the breast]]
| Stains    =
| IHC        = ER +ve, PR +ve, HER2 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[breast]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx        = surgical
}}
'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref name=pmid25789036>{{Cite journal  | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref>
'''Invasive cribriform carcinoma of the breast''' is a rare type of [[breast cancer]] with a favourable prognosis.<ref name=pmid25789036>{{Cite journal  | last1 = Cong | first1 = Y. | last2 = Qiao | first2 = G. | last3 = Zou | first3 = H. | last4 = Lin | first4 = J. | last5 = Wang | first5 = X. | last6 = Li | first6 = X. | last7 = Li | first7 = Y. | last8 = Zhu | first8 = S. | title = Invasive cribriform carcinoma of the breast: A report of nine cases and a review of the literature. | journal = Oncol Lett | volume = 9 | issue = 4 | pages = 1753-1758 | month = Apr | year = 2015 | doi = 10.3892/ol.2015.2972 | PMID = 25789036 }}</ref>


==General==
==General==
*Rare.
*Rare ~ 0.6% of breast cancer in one series.<ref>{{Cite journal  | last1 = Stutz | first1 = JA. | last2 = Evans | first2 = AJ. | last3 = Pinder | first3 = S. | last4 = Ellis | first4 = IO. | last5 = Yeoman | first5 = LJ. | last6 = Wilson | first6 = AR. | last7 = Sibbering | first7 = DM. | title = The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team. | journal = Clin Radiol | volume = 49 | issue = 10 | pages = 693-5 | month = Oct | year = 1994 | doi =  | PMID = 7955831 }}</ref>
*Low Grade.
*Low grade.
*Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal  | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi =  | PMID = 6884999 }}</ref>
*Good prognosis if pure or associated with a tubular invasive component.<ref name=pmid6884999>{{Cite journal  | last1 = Page | first1 = DL. | last2 = Dixon | first2 = JM. | last3 = Anderson | first3 = TJ. | last4 = Lee | first4 = D. | last5 = Stewart | first5 = HJ. | title = Invasive cribriform carcinoma of the breast. | journal = Histopathology | volume = 7 | issue = 4 | pages = 525-36 | month = Jul | year = 1983 | doi =  | PMID = 6884999 }}</ref>


==Microscopic==
==Microscopic==
Features:<ref name=pmid23412348/>
*[[Cribriform]] (or sieve-like) architecture.
*[[Desmoplastic stroma]].
*+/-[[Tubular carcinoma of the breast|Tubular]] component.
Notes:
*Cribriform component should be >90% of the tumour.<ref name=pmid23412348>{{Cite journal  | last1 = Zhang | first1 = W. | last2 = Zhang | first2 = T. | last3 = Lin | first3 = Z. | last4 = Zhang | first4 = X. | last5 = Liu | first5 = F. | last6 = Wang | first6 = Y. | last7 = Liu | first7 = H. | last8 = Yang | first8 = Y. | last9 = Niu | first9 = Y. | title = Invasive cribriform carcinoma in a Chinese population: comparison with low-grade invasive ductal carcinoma-not otherwise specified. | journal = Int J Clin Exp Pathol | volume = 6 | issue = 3 | pages = 445-57 | month =  | year = 2013 | doi =  | PMID = 23412348  | PMC = 3563205}}</ref>
*Low or intermediate Nottingham grade.
DDx:
*Cribriform [[DCIS]].
*[[Tubular carcinoma of the breast]].
*[[Invasive ductal carcinoma of the breast]] with cribriform component.
*[[Adenoid cystic carcinoma of the breast]].


===Images===
===Images===
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Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB)
Image:Breast CribriformCarcinoma HP SNP.jpg|Breast invasive cribriform carcinoma - high power. (SKB)
</gallery>
</gallery>
www:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3563205/figure/fig01/ ICC - panels A-C (nih.gov)].<ref name=pmid23412348/>


==IHC==
==IHC==
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