Difference between revisions of "Bizarre parosteal osteochondromatous proliferation"

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[[Category:Diagnosis]]
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[[Category:Chondro-osseous tumours]]

Latest revision as of 02:43, 30 November 2014

Bizarre parosteal osteochondromatous proliferation
Diagnosis in short

Bizarre parosteal osteochondromatous proliferation. H&E stain.

Synonyms Nora lesion

LM disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone, proliferation of fibroblasts surrounds the bone/cartilage and occupies the intertrabecular spaces
LM DDx periosteal chondrosarcoma, periosteal chondroma, low grade parosteal osteosarcoma, osteochondroma
Site bone (see chondro-osseous tumours) - hands and feet

Prevalence rare
Prognosis benign/locally aggressive

Bizarre parosteal osteochondromatous proliferation, also known as Nora lesion, is a distinctive rare lesion of the hand or foot.[1]

General

A distinctive osteochondromatous proliferation of hands and feet.

Population:

  • Young adults.
  • Typically age (years) 20s and 30s.[1]

Prognosis:

  • Benign.
  • Locally aggressive.

Location

  • Hands and feet.

Radiology

  • Marginated wide based bony growth projecting into the soft tissues.[2]

Gross

Microscopic

Features:

  • Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. *Proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

DDx:

Images

www:

Diagnostic categories

  • Cartilaginous neoplasms.
  • Osteocartilaginous neoplasms.

Molecular

  • t(1:17)(q32;q21).[3]

Sign out

  • BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
  • APPROPRIATE MARGIN STATEMENT.

See also

References

  1. 1.0 1.1 Gruber, G.; Giessauf, C.; Leithner, A.; Zacherl, M.; Clar, H.; Bodo, K.; Windhager, R. (Dec 2008). "Bizarre parosteal osteochondromatous proliferation (Nora lesion): a report of 3 cases and a review of the literature.". Can J Surg 51 (6): 486-9. PMID 19057740.
  2. URL: http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation. Accessed on: 29 November 2014.
  3. Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.

External links