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'''Vermiform appendix''' is Usually just called ''appendix''.  Taking it out is the bread 'n butter of general surgery.
The '''vermiform appendix''', usually just '''appendix''', is a little thingy that is attached to the [[cecum]].  Taking it out is the bread 'n butter of [[general surgery]].
 
The appendix is a vestigial structure that is thought to have arisen from a larger cecum.  Larger cecae are often seen in herbivores and thought to facilitate better digestion of plant matter.<ref>{{cite book |author=Dawkins, R. |title=The Greatest Show on Earth: The Evidence for Evolution |publisher=Free Press |location= |year=2009 |pages=115 |edition=1st |isbn=978-1416594789 |oclc= |doi= |accessdate=}}</ref>
 
=Normal=
==Normal vermiform appendix==
===General===
*Seen in:
**Right hemicolectomies.
***[[colorectal carcinoma|Colon cancer]].
***[[Crohn's disease]].
**Surgeries for ovarian mucinous tumours.


==Acute appendicitis==
===Gross===
===Gross===
*Serosal surface dull.
*Shiny serosal surface.
*May be perforated.
**No exudate.
*+/-Fibrinous exudate.
*Normal diameter.
**6.6 +/- 1.5 mm -- based on CT.<ref name=pmid21344807>{{Cite journal  | last1 = Charoensak | first1 = A. | last2 = Pongpornsup | first2 = S. | last3 = Suthikeeree | first3 = W. | title = Wall thickness and outer diameter of the normal appendix in adults using 64 slices multidetector CT. | journal = J Med Assoc Thai | volume = 93 | issue = 12 | pages = 1437-42 | month = Dec | year = 2010 | doi =  | PMID = 21344807 }}</ref>


===Micro. definition===
===Microscopic===
*[[Neutrophil]]s in the [[muscularis propria]].
Features:
*+/-Lymphoid hyperplasia - mucosa or submucosa.
*Normal colorectal-type mucosa.
*Fatty submucosa.
*Benign smooth muscle.
*Serosa.


==Tumours of the appendix==
Negatives:
==Adenocarcinoma==
*No [[neutrophil]]s in the muscularis propria.
*Like ''colorectal adenocarcinoma'' - see ''[[colon]]''.
*No lesion in appendiceal tip.
*No serosal inflammation ([[periappendicitis]]).
*No organisms in the appendiceal lumen, e.g. [[Enterobius vermicularis]].


==Mucinous tumour==
DDx:
General
*[[Adenovirus appendicitis]].
*classification is controversial.
*[[Cryptosporidiosis]].
**the controversy centres on whether to call all mucinous tumours outside of the appendix adenocarcinoma - regardless of whether they have atypia & show invasion.
*Mild colitis.
*in women - an ovarian primary must be excluded.
**concurrent ''bilateral'' ovarian tumours suggests the tumour originated from the appendix and spread to the ovaries.


Classification<ref name=pmid12883241>{{cite journal |author=Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH |title=Appendiceal mucinous neoplasms: a clinicopathologic analysis of 107 cases |journal=Am. J. Surg. Pathol. |volume=27 |issue=8 |pages=1089–103 |year=2003 |month=August |pmid=12883241 |doi= |url=http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0147-5185&volume=27&issue=8&spage=1089}}</ref>  
===Sign out===
*benign - ''low grade mucinous tumour''.
<pre>
*borderline - ''mucinous tumour of uncertain malignant potential'' or ''borderline mucinous tumour''.
VERMIFORM APPENDIX WITHIN NORMAL LIMITS.
*malignant - ''mucinous adenocarcinoma''.
</pre>


Five year survival<ref name=pmid12883241/>
Note:
{| class="wikitable"
*This is for a normal appendix within a larger operation. The article ''[[negative appendectomy]]'' deals with a normal appearing appendix that was removed for presumed appendicitis.
| ||'''5 year survival'''
|-
|LAMN ||100%
|-
|LAMN ex-appy ||86%
|-
|MACA ||44%
|-
|}
*LAMN = low-grade appendiceal mucinous neoplasm
*LAMN ex-appy = LAMN with extra-appendiceal spread
*MACA = mucinous adenocarcinoma


===Benign mucinous tumour===
==Negative appendectomy==
Micro.
{{Main|Negative appendectomy}}
*Epithelium forms ''tufts'' - vaguely resemble ''serrations'', i.e. the ''saw-tooth'' pattern in hyperplastic polyps.
An appendectomy done for presumed [[acute appendicitis]] that is pathologically within normal limits
*Single layer of epithelium.
*Mucin contained (inside appendix only).


Negatives
=Inflammatory pathologies=
*No marked nuclear atypia.
==Acute appendicitis==
*No invasion into the lamina propria.
{{Main|Acute appendicitis}}


===Borderline mucinous tumour===
==Adenovirus appendicitis==
Micro.
{{Main|Adenovirus appendicitis}}
*Same as benign, but mucin outside of the appendix.
*Cells in mucin, i.e. cellular mucin.


===Malignant mucinous tumour===
==Enterobius vermicularis==
Micro.
{{Main|Enterobius vermicularis}}
*Marked nuclear pleomorphism.
*[[AKA]] ''pinworm''.
*Invasion into the wall.
===General===
*May be found in the appendix.
*The incidence is higher in normal appendices than inflamed ones.<ref name=pmid1853157>{{Cite journal  | last1 = Wiebe | first1 = BM. | title = Appendicitis and Enterobius vermicularis. | journal = Scand J Gastroenterol | volume = 26 | issue = 3 | pages = 336-8 | month = Mar | year = 1991 | doi =  | PMID = 1853157 }}</ref><ref name=pmid7945067/>
*Clinically mimics appendicitis.<ref>{{cite journal |author=Ariyarathenam AV, Nachimuthu S, Tang TY, Courtney ED, Harris SA, Harris AM |title=Enterobius vermicularis infestation of the appendix and management at the time of laparoscopic appendectomy: case series and literature review |journal=Int J Surg |volume=8 |issue=6 |pages=466–9 |year=2010 |pmid=20637320 |doi=10.1016/j.ijsu.2010.06.007 |url=}}</ref>
 
===Microscopic===
Features:
*Usu. the appendiceal wall has no inflammation, i.e. there is no appendicitis.<ref name=pmid1853157/><ref name=pmid7945067>{{Cite journal  | last1 = Dahlstrom | first1 = JE. | last2 = Macarthur | first2 = EB. | title = Enterobius vermicularis: a possible cause of symptoms resembling appendicitis. | journal = Aust N Z J Surg | volume = 64 | issue = 10 | pages = 692-4 | month = Oct | year = 1994 | doi =  | PMID = 7945067 }}</ref>
*''[[Enterobius vermicularis]]'' organisms.
 
====Image====
<gallery>
Image:Enterobius_-_very_low_mag.jpg | Enterobius - very low mag. (WC/Nephron)
Image:Enterobius_-_high_mag.jpg | Enterobius - high mag. (WC/Nephron)
Image:Pinworms_in_the_Appendix_%281%29.jpg | Pinworm (WC/Uthman)
</gallery>


==Granulomatous appendicitis==
==Granulomatous appendicitis==
Features:
{{Main|Granulomatous appendicitis}}
*Granulomas.
 
==Inflammatory bowel disease==
: See ''[[Inflammatory bowel disease]]''.


Most common:
==Periappendicitis==
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>  
===General===
Definition: inflammation of tissues around the (vermiform) appendix.<ref>URL: [http://www.medilexicon.com/medicaldictionary.php?t=66889 http://www.medilexicon.com/medicaldictionary.php?t=66889]. Accessed on: 1 June 2011.</ref>


DDx:<ref>[http://granuloma.homestead.com/appendicitis.html http://granuloma.homestead.com/appendicitis.html]</ref>
*May be seen in association of appendicitis or alone.
*Yersinia appendicitis.<ref name=pmid11257626>{{cite journal |author=Lamps LW, Madhusudhan KT, Greenson JK, ''et al.'' |title=The role of Yersinia enterocolitica and Yersinia pseudotuberculosis in granulomatous appendicitis: a histologic and molecular study |journal=Am. J. Surg. Pathol. |volume=25 |issue=4 |pages=508–15 |year=2001 |month=April |pmid=11257626 |doi= |url=}}</ref>  
**With appendicitis it is suggestive of perforation.
**Yersinia = gram negative rod.
**Without concurrent appendicitis it is suggestive of another abdominal pathology.<ref name=pmid2349982>{{Cite journal | last1 = Fink | first1 = AS. | last2 = Kosakowski | first2 = CA. | last3 = Hiatt | first3 = JR. | last4 = Cochran | first4 = AJ. | title = Periappendicitis is a significant clinical finding. | journal = Am J Surg | volume = 159 | issue = 6 | pages = 564-8 | month = Jun | year = 1990 | doi = | PMID = 2349982 }}</ref><ref>{{Cite journal  | last1 = O'Neil | first1 = MB. | last2 = Moore | first2 = DB. | title = Periappendicitis: Clinical reality or pathologic curiosity? | journal = Am J Surg | volume = 134 | issue = 3 | pages = 356-7 | month = Sep | year = 1977 | doi =  | PMID = 900337 }}</ref>
*Other micro-organism (TB, fungus).
*Crohn's disease.
*Sarcoidosis.
*Foreign body reaction.
*Interval (delayed) appendectomy.


==Goblet cell carcinoid==
===Microscopic===
*Rare appendiceal tumour that typically has an aggressive course vis-a-vis other appendiceal carcinoid.<ref name=pmid18042066>PMID 18042066.</ref>
Features:
*AKA '''crypt cell carcinoma''' - probably a better descriptor.<ref name=pmid18042066>PMID 18042066.</ref>
*Acute inflammation of the serosa.
*Mixed (biphasic) tumour with endocrine and exocrine features.
**[[Neutrophil]]s in the serosa.


===Histology===
DDx:
Features:<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>
*[[Acute appendicitis]].
*Mixed neuroendocrine-nonneuroendocrine tumour;<ref name=pmid17684764>PMID 17684764.</ref> features of both ''carcinoid'' and ''adenocarcinoma.<ref name=pmid15967038>PMID 15967038.</ref>
**Archictecture: cells arranged in nests or clusters without a lumen.
**Location: deep to the intestinal crypts (crypts of Lieberkühn); usually do not involve the mucosa.
**Cytoplasm distended with mucin.
**DNA: crescentic nucleus (similar to in signet-ring cells).
***+/-Multinucleation.
***+/-High mitotic rate.
***Usually minimal nuclear atypia.


===Stains===
=Tumours of the appendix=
*Mucin stains +ve:
==Adenocarcinoma==
**Mucicarmine, perodic acid-Schiff diastase (PAS-D), alician blue.
*Like ''colorectal adenocarcinoma'' - see ''[[colorectal tumours]]''.


====IHC====
==Mucinous tumours of the appendix==
*Classic neuroendocrine markers:
{{Main|Mucinous tumours of the appendix}}
**Synaptophysin +ve.
This grouping includes ''mucinous cystadenoma'' and ''mucinous cystadenocarcinoma''.
**Chromogranin +ve.
*S100 +ve.
*NSE +ve.
*Serotonin +ve.


Keratins:
==Goblet cell adenocarcinoma==
*Usually CK20 +ve > CK7 +ve.
{{Main|Goblet cell adenocarcinoma}}
*Previously known as ''goblet cell carcinoid''.


*CEA +ve (membrane).
==Neuroendocrine tumour of the appendix==
*Previously known as ''appendiceal carcinoid''.
*[[AKA]] ''appendiceal neuroendocrine tumour'', abbreviated ''appendiceal NET''.
{{Main|Neuroendocrine tumour of the appendix}}


Notes:
=See also=
*Nice review of stains in Pahlavan and Kanthan.<ref name=pmid15967038>{{cite journal |author=Pahlavan PS, Kanthan R |title=Goblet cell carcinoid of the appendix |journal=World J Surg Oncol |volume=3 |issue= |pages=36 |year=2005 |month=June |pmid=15967038 |pmc=1182398 |doi=10.1186/1477-7819-3-36 |url=http://wjso.com/content/3/1/36}}</ref>
*[[Colon]].
==See also==
*[[Gastrointestinal pathology]].
*[[Colon]]
*[[Gastrointestinal pathology]]


==References==
=References=
{{reflist|2}}
{{reflist|2}}


[[Category:Gastrointestinal pathology]]
[[Category:Gastrointestinal pathology]]
[[Category:Vermiform appendix]]
Retrieved from "https://librepathology.org/wiki/Vermiform_appendix"