Benign lymphoepithelial lesion: Difference between revisions
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*Usually parotid gland. | *Usually parotid gland. | ||
*Associated with autoimmune disease, e.g. [[Sjoegren disease]], may not remain benign.<ref name=pmid12058269>{{Cite journal | last1 = Goto | first1 = TK. | last2 = Shimizu | first2 = M. | last3 = Kobayashi | first3 = I. | last4 = Chikui | first4 = T. | last5 = Kanda | first5 = S. | last6 = Toshitani | first6 = K. | last7 = Shiratsuchi | first7 = Y. | last8 = Yoshida | first8 = K. | title = Lymphoepithelial lesion of the parotid gland. | journal = Dentomaxillofac Radiol | volume = 31 | issue = 3 | pages = 198-203 | month = May | year = 2002 | doi = 10.1038/sj/dmfr/4600690 | PMID = 12058269 }}</ref> | *Associated with autoimmune disease, e.g. [[Sjoegren disease]], may not remain benign.<ref name=pmid12058269>{{Cite journal | last1 = Goto | first1 = TK. | last2 = Shimizu | first2 = M. | last3 = Kobayashi | first3 = I. | last4 = Chikui | first4 = T. | last5 = Kanda | first5 = S. | last6 = Toshitani | first6 = K. | last7 = Shiratsuchi | first7 = Y. | last8 = Yoshida | first8 = K. | title = Lymphoepithelial lesion of the parotid gland. | journal = Dentomaxillofac Radiol | volume = 31 | issue = 3 | pages = 198-203 | month = May | year = 2002 | doi = 10.1038/sj/dmfr/4600690 | PMID = 12058269 }}</ref> | ||
*May be seen in the context of [[HIV]].<ref>{{cite journal |authors=Sekikawa Y, Hongo I |title=HIV-associated benign lymphoepithelial cysts of the parotid glands confirmed by HIV-1 p24 antigen immunostaining |journal=BMJ Case Rep |volume=2017 |issue= |pages= |date=September 2017 |pmid=28963391 |pmc=5652621 |doi=10.1136/bcr-2017-221869 |url=}}</ref> | |||
==Microscopic== | ==Microscopic== | ||
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*CD20, CD3 -- mixed population. | *CD20, CD3 -- mixed population. | ||
*Kappa ~ lambda. | *Kappa ~ lambda. | ||
==Sign out== | |||
<pre> | |||
Right Total Parotid Gland, Excision: | |||
- Lymphoepithelial lesion/cyst, benign. | |||
- Benign parotid gland. | |||
- Two lymph nodes, NEGATIVE for malignancy (0/2). | |||
</pre> | |||
===Micro=== | |||
The sections show a multiloculated cyst with thin walls containing bland lymphoid cells and unremarkable paucicellular fibrotic tissue. The lymphoid component has germinal centre formation. The cyst lining is predominantly a simple thin epithelium. Minimal cytoplasm is present in the cyst lining. Focally, the epithelium is multilayered; however, pseudo-bilayering is absent. No significant atypia is present. Proliferative activity is not apparent. | |||
==See also== | ==See also== | ||