Difference between revisions of "Renal cell carcinoma with rhabdoid morphology"

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[[Image: Renal cell carcinoma with rhabdoid change -- intermed mag.jpg|thumb|300px|[[Micrograph]] showing rhabdoid change in a renal cell carcinoma. [[H&E stain]].]]
'''Renal cell carcinoma with rhabdoid morphology''' is an uncommon finding with a poor prognosis. It is also known as '''renal cell carcinoma with rhabdoid change'''.
'''Renal cell carcinoma with rhabdoid morphology''' is an uncommon finding with a poor prognosis. It is also known as '''renal cell carcinoma with rhabdoid change'''.
It should '''not''' be confused with [[renal rhabdoid tumour]].


==General==
==General==
*Not recognized as a distinct entity.<ref name=pmid21665507>{{Cite journal  | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref>
*Not recognized as a distinct entity.<ref name=pmid21665507>{{Cite journal  | last1 = Chapman-Fredricks | first1 = JR. | last2 = Herrera | first2 = L. | last3 = Bracho | first3 = J. | last4 = Gomez-Fernandez | first4 = C. | last5 = Leveillee | first5 = R. | last6 = Rey | first6 = L. | last7 = Jorda | first7 = M. | title = Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma. | journal = Ann Diagn Pathol | volume = 15 | issue = 5 | pages = 333-7 | month = Oct | year = 2011 | doi = 10.1016/j.anndiagpath.2011.03.002 | PMID = 21665507 }}</ref>
*[[ISUP nucleolar grade]] 4 by definition.
*May be seen in [[ALK translocation renal cell carcinoma]].<ref name=pmid26017874>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Karashima | first2 = T. | last3 = Inoue | first3 = K. | last4 = Kasajima | first4 = A. | last5 = Ohe | first5 = C. | last6 = Kawakami | first6 = F. | last7 = Mikami | first7 = S. | last8 = Matsuura | first8 = K. | last9 = Moriyama | first9 = M. | title = Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. | journal = Pol J Pathol | volume = 66 | issue = 1 | pages = 3-8 | month = Mar | year = 2015 | doi =  | PMID = 26017874 }}</ref>


==Microscopic==
==Microscopic==
Features:
Features:
*[[Rhabdoid cells]]:  
*[[Rhabdoid cells]]:  
**Eccentrically placed large round nuclei with very prominent nucleoli.
**Eccentrically placed large round nuclei with abundant eosinophilic cytoplasm.
**Abundant eosinophilic cytoplasm.
**+/-Very prominent [[nucleolus]].


Notes:
Notes:
*May be multinucleated.
*May be multinucleated.
===Images===
<gallery>
Image: Renal cell carcinoma with rhabdoid change -- low mag.jpg | RCC with RC - low mag.
Image: Renal cell carcinoma with rhabdoid change -- intermed mag.jpg | RCC with RC - intermed. mag.
Image: Renal cell carcinoma with rhabdoid change -- high mag.jpg | RCC with RC - high mag.
Image: Renal cell carcinoma with rhabdoid change -- very high mag.jpg | RCC with RC - very high mag.
Image: Renal cell carcinoma with rhabdoid change - alt -- very high mag.jpg | RCC with RC - very high mag.
</gallery>


==IHC==
==IHC==
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*Desmin -ve (23 of 23 cases).
*Desmin -ve (23 of 23 cases).
*SMA -ve (~5% of cases).
*SMA -ve (~5% of cases).
==Sign out==
<pre>
MASS, RIGHT KIDNEY, RADICAL NEPHRECTOMY:
- CLEAR CELL RENAL CELL CARCINOMA, ISUP NUCLEOLAR GRADE 4, pT1b, pNX.
-- RHABDOID CHANGE PRESENT, SEE COMMENT.
-- MARGINS NEGATIVE FOR MALIGNANCY.
-- PLEASE SEE TUMOUR SUMMARY.
COMMENT:
Rhabdoid change is considered by some to be analogous to sarcomatoid
change.[1]  The rhabdoid change in this case represents approximately
35% of the tumour, and has ISUP nucleolar grade 4 nuclear features.
1. Ann Diagn Pathol. 2011 Oct;15(5):333-7.
</pre>


==See also==
==See also==
*[[Renal cell carcinoma]].
*[[Renal cell carcinoma]].
*[[Renal cell carcinoma with sarcomatoid differentiation]].
*[[Rhabdoid]].
*[[ISUP nucleolar grade]].


==References==
==References==

Latest revision as of 20:04, 4 April 2019

Micrograph showing rhabdoid change in a renal cell carcinoma. H&E stain.

Renal cell carcinoma with rhabdoid morphology is an uncommon finding with a poor prognosis. It is also known as renal cell carcinoma with rhabdoid change.

It should not be confused with renal rhabdoid tumour.

General

Microscopic

Features:

  • Rhabdoid cells:
    • Eccentrically placed large round nuclei with abundant eosinophilic cytoplasm.
    • +/-Very prominent nucleolus.

Notes:

  • May be multinucleated.

Images

  • RCC with RC - low mag.

  • RCC with RC - intermed. mag.

  • RCC with RC - high mag.

  • RCC with RC - very high mag.

  • RCC with RC - very high mag.

IHC

Features:[3]

  • Vimentin +ve (23 of 23 cases).
  • NSE +ve (~80% of cases).
  • S-100 -ve/+ve (+ve ~ 40% of cases).
  • Desmin -ve (23 of 23 cases).
  • SMA -ve (~5% of cases).

Sign out

MASS, RIGHT KIDNEY, RADICAL NEPHRECTOMY:
- CLEAR CELL RENAL CELL CARCINOMA, ISUP NUCLEOLAR GRADE 4, pT1b, pNX.
-- RHABDOID CHANGE PRESENT, SEE COMMENT.
-- MARGINS NEGATIVE FOR MALIGNANCY.
-- PLEASE SEE TUMOUR SUMMARY.

COMMENT:
Rhabdoid change is considered by some to be analogous to sarcomatoid 
change.[1]  The rhabdoid change in this case represents approximately 
35% of the tumour, and has ISUP nucleolar grade 4 nuclear features.

1. Ann Diagn Pathol. 2011 Oct;15(5):333-7.

See also

References

  1. ↑ Chapman-Fredricks, JR.; Herrera, L.; Bracho, J.; Gomez-Fernandez, C.; Leveillee, R.; Rey, L.; Jorda, M. (Oct 2011). "Adult renal cell carcinoma with rhabdoid morphology represents a neoplastic dedifferentiation analogous to sarcomatoid carcinoma.". Ann Diagn Pathol 15 (5): 333-7. doi:10.1016/j.anndiagpath.2011.03.002. PMID 21665507.
  2. ↑ Kuroda, N.; Karashima, T.; Inoue, K.; Kasajima, A.; Ohe, C.; Kawakami, F.; Mikami, S.; Matsuura, K. et al. (Mar 2015). "Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects.". Pol J Pathol 66 (1): 3-8. PMID 26017874.
  3. ↑ Gökden, N.; Nappi, O.; Swanson, PE.; Pfeifer, JD.; Vollmer, RT.; Wick, MR.; Humphrey, PA. (Oct 2000). "Renal cell carcinoma with rhabdoid features.". Am J Surg Pathol 24 (10): 1329-38. PMID 11023094.
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