Clear cell carcinoma of the vagina: Difference between revisions
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'''Clear cell carcinoma of the vagina''' is a very rare epithelial [[malignancy]] of the vagina.<ref name=pmid22713709>{{Cite journal | last1 = Ansari | first1 = DO. | last2 = Horowitz | first2 = IR. | last3 = Katzenstein | first3 = HM. | last4 = Durham | first4 = MM. | last5 = Esiashvili | first5 = N. | title = Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy. | journal = J Pediatr Hematol Oncol | volume = 34 | issue = 5 | pages = e174-6 | month = Jul | year = 2012 | doi = 10.1097/MPH.0b013e318257dc91 | PMID = 22713709 }}</ref> | '''Clear cell carcinoma of the vagina''' is a very rare epithelial [[malignancy]] of the [[vagina]].<ref name=pmid22713709>{{Cite journal | last1 = Ansari | first1 = DO. | last2 = Horowitz | first2 = IR. | last3 = Katzenstein | first3 = HM. | last4 = Durham | first4 = MM. | last5 = Esiashvili | first5 = N. | title = Successful treatment of an adolescent with locally advanced cervicovaginal clear cell adenocarcinoma using definitive chemotherapy and radiotherapy. | journal = J Pediatr Hematol Oncol | volume = 34 | issue = 5 | pages = e174-6 | month = Jul | year = 2012 | doi = 10.1097/MPH.0b013e318257dc91 | PMID = 22713709 }}</ref> | ||
==General== | ==General== | ||
*Often lumped the [[clear cell carcinoma of the uterine cervix]].<ref name=pmid22713709/> | *Often lumped the [[clear cell carcinoma of the uterine cervix]].<ref name=pmid22713709/> | ||
==Microscopic== | |||
:See ''[[clear cell carcinoma of the uterine cervix]]''. | |||
===Images=== | |||
====Case==== | |||
<gallery> | |||
Image: Clear cell carcinoma - gynecologic tract -- low mag.jpg | CCC - low mag. | |||
Image: Clear cell carcinoma - gynecologic tract -- intermed mag.jpg | CCC - intermed. mag. | |||
Image: Clear cell carcinoma - gynecologic tract -- high mag.jpg | CCC - high mag. | |||
Image: Clear cell carcinoma - gynecologic tract -- very high mag.jpg | CCC - very high mag. | |||
Image: Clear cell carcinoma - gynecologic tract - HE -- intermed mag.jpg | CCC - intermed. mag. | |||
Image: Clear cell carcinoma - gynecologic tract - PAS -- high mag.jpg | CCC - high mag. | |||
Image: Clear cell carcinoma - gynecologic tract - PASD -- high mag.jpg | CCC - high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.webpathology.com/image.asp?n=16&Case=543 CCC of the vagina (webpathology.com)]. | |||
==Sign out== | |||
<pre> | |||
VAGINAL VAULT, BIOPSY: | |||
- CLEAR CELL CARCINOMA, SEE COMMENT. | |||
COMMENT: | |||
The tumour stains as follows: | |||
POSITIVE: CK7, CAM5.2, PAS. | |||
NEGATIVE: ER, PR, p53, p16, WT-1, PASD. | |||
PROLIFERATION: ~60%. | |||
</pre> | |||
===Micro=== | |||
The sections show a tumour with a papillary cystic architecture that is composed of moderately atypical monomorphic cells with moderate pale grey cytoplasm. Focal cytoplasmic clearing is present. Hobnailing is present focally. The nucleoli are not prominent. | |||
==See also== | ==See also== | ||
*[[Vagina]]. | *[[Vagina]]. | ||
*[[Clear cell carcinoma]]. | |||
==References== | ==References== | ||