Chondrocalcinosis: Difference between revisions
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| Width = | | Width = | ||
| Caption = Chondrocalcinosis. [[H&E stain]]. | | Caption = Chondrocalcinosis. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = calcium pyrophosphate dihydrate deposition disease, calcium pyrophosphate deposition, pseudogout (old term) | ||
| Micro = crystals with a rhomboid-shape | | Micro = crystals with a rhomboid-shape; polarized light: positively birefringent, blue when aligned | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = benign calcifications, [[osteoarthritis]] | | LMDDx = benign calcifications, [[osteoarthritis]] | ||
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| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = +/-subchondral cysts, degeneration of cartilage | ||
| Grossing = | | Grossing = | ||
| Site = [[joints]] - especially knee | | Site = [[joints]] - especially knee | ||
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| Prevalence = uncommon | | Prevalence = uncommon | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = +/-[[loose bodies]] | | Rads = +/-[[loose bodies]], joint space narrowing, narrowing of patellofemoral joint | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign | | Prognosis = benign | ||
| Other = | | Other = | ||
| ClinDDx = [[osteoarthritis]] | | ClinDDx = [[osteoarthritis]], other types of [[arthritis]] | ||
| Tx = | | Tx = | ||
}} | }} | ||
'''Chondrocalcinosis''', also '''calcium pyrophosphate deposition''' and '''calcium pyrophosphate dihydrate deposition disease''' (abbreviated '''CPPD'''),<ref>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001458/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001458/]. Accessed on: 28 October 2011.</ref> is a benign condition of the [[joints]]. | '''Chondrocalcinosis''', also '''calcium pyrophosphate deposition''' and '''calcium pyrophosphate dihydrate deposition disease''' (abbreviated '''CPPD'''),<ref>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001458/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001458/]. Accessed on: 28 October 2011.</ref> is a benign condition of the [[joints]]. | ||
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*Associated with low bone mineral density and vascular calcification.<ref name=pmid23912799>{{Cite journal | last1 = Abhishek | first1 = A. | last2 = Doherty | first2 = S. | last3 = Maciewicz | first3 = R. | last4 = Muir | first4 = K. | last5 = Zhang | first5 = W. | last6 = Doherty | first6 = M. | title = Association between low cortical bone mineral density, soft-tissue calcification, vascular calcification and chondrocalcinosis: a case-control study. | journal = Ann Rheum Dis | volume = | issue = | pages = | month = Aug | year = 2013 | doi = 10.1136/annrheumdis-2013-203400 | PMID = 23912799 }}</ref> | *Associated with low bone mineral density and vascular calcification.<ref name=pmid23912799>{{Cite journal | last1 = Abhishek | first1 = A. | last2 = Doherty | first2 = S. | last3 = Maciewicz | first3 = R. | last4 = Muir | first4 = K. | last5 = Zhang | first5 = W. | last6 = Doherty | first6 = M. | title = Association between low cortical bone mineral density, soft-tissue calcification, vascular calcification and chondrocalcinosis: a case-control study. | journal = Ann Rheum Dis | volume = | issue = | pages = | month = Aug | year = 2013 | doi = 10.1136/annrheumdis-2013-203400 | PMID = 23912799 }}</ref> | ||
==Radiology== | ==Gross== | ||
*Degeneration of cartilage. | |||
*Subchondral sclerosis. | |||
===Radiology=== | |||
*Similar to [[osteoarthritis]] - joint space narrowing & subchondral sclerosis.<ref name=learningrads>URL: [http://www.learningradiology.com/archives04/COW%20102-CPPD/cppdcorrectpage.htm http://www.learningradiology.com/archives04/COW%20102-CPPD/cppdcorrectpage.htm]. Accessed on: 9 October 2013.</ref> | *Similar to [[osteoarthritis]] - joint space narrowing & subchondral sclerosis.<ref name=learningrads>URL: [http://www.learningradiology.com/archives04/COW%20102-CPPD/cppdcorrectpage.htm http://www.learningradiology.com/archives04/COW%20102-CPPD/cppdcorrectpage.htm]. Accessed on: 9 October 2013.</ref> | ||
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- CRYSTALS CONSISTENT WITH PSEUDOGOUT. | - CRYSTALS CONSISTENT WITH PSEUDOGOUT. | ||
- SYNOVIAL HYPERPLASIA WITH RARE GIANT CELLS. | - SYNOVIAL HYPERPLASIA WITH RARE GIANT CELLS. | ||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
<pre> | |||
FEMORAL HEAD AND JOINT CAPSULE, LEFT, HIP ARTHROPLASTY: | |||
- DEGENERATIVE JOINT DISEASE WITH MILD LYMPHOPLASMACYTIC INFLAMMATION. | |||
- CRYSTALLINE DEPOSITS CONSISTENT WITH CHONDROCALCINOSIS. | |||
- NEGATIVE FOR MALIGNANCY. | - NEGATIVE FOR MALIGNANCY. | ||
</pre> | </pre> | ||