Difference between revisions of "Angiomyofibroblastoma"
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'''Angiomyofibroblastoma''' is rare uncommon [[soft tissue lesion]] of the [[vulva]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Angiomyofibroblastoma humpath 4.jpg | |||
| Width = | |||
| Caption = Angiomyofibroblastoma. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, [[myxoid stroma]], small stellate cell/spindle cells without significant nuclear atypia | |||
| Subtypes = | |||
| LMDDx = [[aggressive angiomyxoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = well-circumscribed | |||
| Grossing = | |||
| Site = female pelvis ([[vulva]]), case reports of similar lesion in males | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = slow growing, usu. not painful | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[Bartholin cyst]], [[aggressive angiomyxoma]] | |||
| Tx = | |||
}} | |||
'''Angiomyofibroblastoma''', abbreviated '''AMF''',<ref name=pmid15782077>{{cite journal |author=Cao D, Srodon M, Montgomery EA, Kurman RJ |title=Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature |journal=Int. J. Gynecol. Pathol. |volume=24 |issue=2 |pages=196–200 |year=2005 |month=April |pmid=15782077 |doi= |url=}}</ref> is rare uncommon [[soft tissue lesion]] of the [[vulva]]. | |||
==General== | ==General== | ||
*Uncommon. | *Uncommon. | ||
*Similar lesions reported in males.<ref name=pmid24396463>{{Cite journal | last1 = Ding | first1 = G. | last2 = Yu | first2 = Y. | last3 = Jin | first3 = M. | last4 = Xu | first4 = J. | last5 = Zhang | first5 = Z. | title = Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 435-438 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1741 | PMID = 24396463 }}</ref><ref>{{Cite journal | last1 = Butt | first1 = Z. | last2 = Slatnik | first2 = J. | last3 = Estey | first3 = EP. | title = Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor. | journal = Can J Urol | volume = 20 | issue = 6 | pages = 7067-9 | month = Dec | year = 2013 | doi = | PMID = 24331351 }}</ref> | *Similar lesions reported in males.<ref name=pmid24396463>{{Cite journal | last1 = Ding | first1 = G. | last2 = Yu | first2 = Y. | last3 = Jin | first3 = M. | last4 = Xu | first4 = J. | last5 = Zhang | first5 = Z. | title = Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review. | journal = Oncol Lett | volume = 7 | issue = 2 | pages = 435-438 | month = Feb | year = 2014 | doi = 10.3892/ol.2013.1741 | PMID = 24396463 }}</ref><ref>{{Cite journal | last1 = Butt | first1 = Z. | last2 = Slatnik | first2 = J. | last3 = Estey | first3 = EP. | title = Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor. | journal = Can J Urol | volume = 20 | issue = 6 | pages = 7067-9 | month = Dec | year = 2013 | doi = | PMID = 24331351 }}</ref> | ||
Clinical:<ref name=pmid24328028/> | |||
*Slow growing. | |||
*Uncommonly recur. | |||
*Usually painless. | |||
Clinical DDx: | Clinical DDx: | ||
| Line 10: | Line 46: | ||
==Gross== | ==Gross== | ||
*[[Vulva|Vulvar lesion]]. | *[[Vulva|Vulvar lesion]]. | ||
*Well-circumscribed.<ref>{{Cite journal | last1 = Seo | first1 = JW. | last2 = Lee | first2 = KA. | last3 = Yoon | first3 = NR. | last4 = Lee | first4 = JW. | last5 = Kim | first5 = BG. | last6 = Bae | first6 = DS. | title = Angiomyofibroblastoma of the vulva. | journal = Obstet Gynecol Sci | volume = 56 | issue = 5 | pages = 349-51 | month = Sep | year = 2013 | doi = 10.5468/ogs.2013.56.5.349 | PMID = 24328028 }}</ref> | *Well-circumscribed.<ref name=pmid24328028>{{Cite journal | last1 = Seo | first1 = JW. | last2 = Lee | first2 = KA. | last3 = Yoon | first3 = NR. | last4 = Lee | first4 = JW. | last5 = Kim | first5 = BG. | last6 = Bae | first6 = DS. | title = Angiomyofibroblastoma of the vulva. | journal = Obstet Gynecol Sci | volume = 56 | issue = 5 | pages = 349-51 | month = Sep | year = 2013 | doi = 10.5468/ogs.2013.56.5.349 | PMID = 24328028 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
| Line 23: | Line 59: | ||
===Images=== | ===Images=== | ||
<gallery> | |||
Image:Angiomyofibroblastoma humpath 1.jpg | AMF - low mag. | |||
Image:Angiomyofibroblastoma humpath 2.jpg | AMF - intermed. mag. | |||
Image:Angiomyofibroblastoma humpath 3.jpg | AMF - high mag. | |||
Image:Angiomyofibroblastoma humpath 4.jpg | AMF - very high mag. | |||
</gallery> | |||
www: | www: | ||
*[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)] | *[http://www.webpathology.com/image.asp?case=544&n=4 Angiomyofibroblastoma (webpathology.com)] | ||
| Line 29: | Line 71: | ||
==IHC== | ==IHC== | ||
*Desmin +ve.<ref name=pmid24328028/> | |||
*Vimentin +ve.<ref name=pmid24328028/> | |||
*SMA +ve. | *SMA +ve. | ||
*S-100 -ve. | *S-100 -ve. | ||
| Line 36: | Line 80: | ||
==See also== | ==See also== | ||
*[[Soft tissue lesions]]. | *[[Soft tissue lesions]]. | ||
*[[Vulva]]. | |||
*[[Scrotum]]. | |||
==References== | ==References== | ||
Latest revision as of 07:56, 8 May 2014
| Angiomyofibroblastoma | |
|---|---|
| Diagnosis in short | |
 Angiomyofibroblastoma. H&E stain. | |
|
| |
| LM | hypercellular zones and hypocellular edematous zones, small blood vessels (~20 micrometers) - no large blood vessels, myxoid stroma, small stellate cell/spindle cells without significant nuclear atypia |
| LM DDx | aggressive angiomyxoma |
| Gross | well-circumscribed |
| Site | female pelvis (vulva), case reports of similar lesion in males |
|
| |
| Clinical history | slow growing, usu. not painful |
| Prevalence | very rare |
| Clin. DDx | Bartholin cyst, aggressive angiomyxoma |
Angiomyofibroblastoma, abbreviated AMF,[1] is rare uncommon soft tissue lesion of the vulva.
General
Clinical:[4]
- Slow growing.
- Uncommonly recur.
- Usually painless.
Clinical DDx:
Gross
- Vulvar lesion.
- Well-circumscribed.[4]
Microscopic
Features:[5]
- Hypercellular zones and hypocellular edematous zones.
- Small blood vessels (~20 micrometers) - no large blood vessels - key feature.
- Myxoid stroma - key feature.
- Small stellate cell/spindle cells without significant nuclear atypia.
DDx:
- Aggressive angiomyxoma - less cellular, large blood vessels.
Images
AMF - low mag.
AMF - intermed. mag.
AMF - high mag.
AMF - very high mag.
www:
- Angiomyofibroblastoma (webpathology.com)
- Angiomyofibroblastoma - high mag. (webpathology.com).
- Angiomyofibroblastoma-like tumour of scrotum (nih.gov).[2]
IHC
See also
References
- ↑ Cao D, Srodon M, Montgomery EA, Kurman RJ (April 2005). "Lipomatous variant of angiomyofibroblastoma: report of two cases and review of the literature". Int. J. Gynecol. Pathol. 24 (2): 196–200. PMID 15782077.
- ↑ 2.0 2.1 Ding, G.; Yu, Y.; Jin, M.; Xu, J.; Zhang, Z. (Feb 2014). "Angiomyofibroblastoma-like tumor of the scrotum: A case report and literature review.". Oncol Lett 7 (2): 435-438. doi:10.3892/ol.2013.1741. PMID 24396463.
- ↑ Butt, Z.; Slatnik, J.; Estey, EP. (Dec 2013). "Robotic assisted laparoscopic excision of a pelvic angiomyofibroblastoma-like tumor.". Can J Urol 20 (6): 7067-9. PMID 24331351.
- ↑ 4.0 4.1 4.2 4.3 Seo, JW.; Lee, KA.; Yoon, NR.; Lee, JW.; Kim, BG.; Bae, DS. (Sep 2013). "Angiomyofibroblastoma of the vulva.". Obstet Gynecol Sci 56 (5): 349-51. doi:10.5468/ogs.2013.56.5.349. PMID 24328028.
- ↑ Fletcher, CD.; Tsang, WY.; Fisher, C.; Lee, KC.; Chan, JK. (Apr 1992). "Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma.". Am J Surg Pathol 16 (4): 373-82. PMID 1314521.