Difference between revisions of "Histology artifacts"
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*Darker well demarcated line with apparent disruption of the architecture. | *Darker well demarcated line with apparent disruption of the architecture. | ||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Basal cell hyperplasia of the prostate -- high mag.jpg | Tissue fold (center of image) in [[basal cell hyperplasia of the prostate]]. | Image:Basal cell hyperplasia of the prostate -- high mag.jpg | Tissue fold (center of image) in [[basal cell hyperplasia of the prostate]]. | ||
Image: Sessile serrated adenoma -- low mag.jpg | Extensive tissue folding in a [[SSA]]. | |||
</gallery> | </gallery> | ||
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*Fine parallel lines. | *Fine parallel lines. | ||
===Images=== | |||
<gallery> | <gallery> | ||
Image:Tubular_adenoma_2_high_mag.jpg | Chatter artifact in [[traditional adenoma|tubular adenoma]]. | Image:Tubular_adenoma_2_high_mag.jpg | Chatter artifact in [[traditional adenoma|tubular adenoma]]. | ||
Image:Complex_endometrial_hyperplasia_--_high_mag.jpg | Chatter artifact in [[complex endometrial hyperplasia]]. | |||
Image:Tumour_infiltrating_lymphocytes_in_colorectal_carcinoma_-_high_mag.jpg | Chatter artifact in [[TILs]]. | |||
</gallery> | |||
==Tissue tearing== | |||
*Usually due to something intrinsic to the tissue that is hard, e.g. calcium. | |||
===Image=== | |||
<gallery> | |||
Image:Tooth_in_teratoma_-_very_low_mag.jpg | Tearing due to a calcification. | |||
</gallery> | |||
==Sponge artifact== | |||
*Angulated pieces of tissue with punched-out missing fragments.<ref name=pmid2252429>{{cite journal |author=Landas SK, Bromley CM |title=Sponge artifact in biopsy specimens |journal=Arch. Pathol. Lab. Med. |volume=114 |issue=12 |pages=1285–7 |year=1990 |month=December |pmid=2252429 |doi= |url=}}</ref> | |||
*May result in little squares of tissue arranged in a regular pattern. | |||
===Images=== | |||
<gallery> | |||
Image: Endometrium with sponge artifact -- very low mag.jpg | Sponge artifact - very low mag. | |||
Image: Endometrium with sponge artifact -- low mag.jpg | Sponge artifact - low mag. | |||
Image: Endometrium with sponge artifact -- intermed mag.jpg | Sponge artifact - intermed. mag. | |||
</gallery> | |||
==Bubble artifact== | |||
===Large=== | |||
*Large bubbles of air under the cover slip. | |||
====Images==== | |||
<gallery> | |||
Image: Coverslip artifact -- intermed mag.jpg | CA - intermed. mag. (WC) | |||
Image: Coverslip artifact -- high mag.jpg | CA - high mag. (WC) | |||
Image: Coverslip artifact - alt -- high mag.jpg | CA - high mag. (WC) | |||
</gallery> | |||
==Coverslip artifact== | |||
Features: | |||
*Black-grey lines - takes on the outline of the tissue beneath it. | |||
*Above the plane-of-focus of the tissue - '''key feature'''. | |||
===Images=== | |||
====Case 1==== | |||
<gallery> | |||
Image: Epididymis with coverslip artifact -- low mag.jpg | CSA - low mag. (WC) | |||
Image: Epididymis with coverslip artifact -- intermed mag.jpg | CSA - intermed mag. (WC) | |||
Image: Epididymis with coverslip artifact -- high mag.jpg | CSA - high mag. (WC) | |||
Image: Epididymis with coverslip artifact - wc -- high mag.jpg | CSA - high mag. (WC) | |||
Image: Epididymis with coverslip artifact - wc -- very high mag.jpg | CSA - very high mag. (WC) | |||
</gallery> | </gallery> | ||
==See also== | ==See also== | ||
*[[Tissue loss]]. | |||
*[[Tissue floater]]. | *[[Tissue floater]]. | ||
*[[Quality]]. | *[[Quality]]. | ||
*[[Foreign material]]. | |||
==References== | |||
{{Reflist|1}} | |||
==External links== | ==External links== | ||
Latest revision as of 16:21, 3 January 2020
Histology artifacts are common.
Cautery artifact
Main article: Cautery artifact
Tissue fold
- Darker well demarcated line with apparent disruption of the architecture.
Images
Tissue fold (center of image) in basal cell hyperplasia of the prostate.
Extensive tissue folding in a SSA.
Chatter artifact
- Fine parallel lines.
Images
Chatter artifact in tubular adenoma.
Chatter artifact in complex endometrial hyperplasia.
Chatter artifact in TILs.
Tissue tearing
- Usually due to something intrinsic to the tissue that is hard, e.g. calcium.
Image
Tearing due to a calcification.
Sponge artifact
- Angulated pieces of tissue with punched-out missing fragments.[1]
- May result in little squares of tissue arranged in a regular pattern.
Images
Sponge artifact - very low mag.
Sponge artifact - low mag.
Sponge artifact - intermed. mag.
Bubble artifact
Large
- Large bubbles of air under the cover slip.
Images
CA - intermed. mag. (WC)
CA - high mag. (WC)
CA - high mag. (WC)
Coverslip artifact
Features:
- Black-grey lines - takes on the outline of the tissue beneath it.
- Above the plane-of-focus of the tissue - key feature.
Images
Case 1
CSA - low mag. (WC)
CSA - intermed mag. (WC)
CSA - high mag. (WC)
CSA - high mag. (WC)
CSA - very high mag. (WC)
