Difference between revisions of "Renal oncocytoma"

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{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Renal_oncocytoma2.jpg
| Image      = Renal oncocytoma -- intermed mag.jpg  
| Width      =
| Width      =
| Caption    = Renal oncocytoma. [[H&E stain]].
| Caption    = Renal oncocytoma (left of image) and normal kidney (right of image). [[Kidney biopsy]]. [[H&E stain]].
| Micro      = abundant eosinophilic cytoplasm - slightly granular, cells arranged in nests, nuclei uniform and round without significant pleomorphism
| Micro      = abundant eosinophilic cytoplasm - slightly granular, cells arranged in nests, nuclei uniform and round without significant pleomorphism
| Subtypes  =
| Subtypes  =
| LMDDx      = [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant
| LMDDx      = [[chromophobe renal cell carcinoma]] eosinophilic variant, [[clear cell renal cell carcinoma]] eosinophilic variant, [[papillary renal cell carcinoma]] oncocytic variant, [[tubulocystic carcinoma of the kidney]], other [[renal tumours with eosinophilic cytoplasm]], benign [[liver]]
| Stains    = [[Hale's colloidal iron]] -ve
| Stains    = [[Hale's colloidal iron]] -ve
| IHC        = CK7 -ve/cytoplasmic +ve  
| IHC        = CK7 -ve/cytoplasmic +ve, CD117 +ve, [[PAX8]] +ve  
| EM        = abundant mitochondria
| EM        = abundant mitochondria
| Molecular  =
| Molecular  =
| IF        =
| IF        =
| Gross      = mass, mahogany brown +/- central scar
| Gross      = mass, mahogany brown +/- central scar
| Grossing  =
| Grossing  = [[partial nephrectomy grossing]], [[total nephrectomy for tumour grossing]]
| Site      = [[kidney]] - see [[kidney tumours]]
| Site      = [[kidney]] - see [[kidney tumours]]
| Assdx      =
| Assdx      =
| Syndromes  =
| Syndromes  =
| Clinicalhx =
| Clinicalhx = often incidentally discovered mass
| Signs      =
| Signs      =
| Symptoms  =
| Symptoms  =
| Prevalence =
| Prevalence =
| Bloodwork  =
| Bloodwork  =
| Rads      = central scar
| Rads      = renal mass with central scar (classic)
| Endoscopy  =
| Endoscopy  =
| Prognosis  = benign
| Prognosis  = benign
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** ... and pathologists occasionally struggle like the radiologists.
** ... and pathologists occasionally struggle like the radiologists.
*Benign tumour - the reason it is excised is... one cannot be certain it isn't a RCC.
*Benign tumour - the reason it is excised is... one cannot be certain it isn't a RCC.
*May be seen in the context of [[renal oncocytosis]].<ref name=pmid23018240>{{Cite journal  | last1 = Kuroda | first1 = N. | last2 = Tanaka | first2 = A. | last3 = Ohe | first3 = C. | last4 = Mikami | first4 = S. | last5 = Nagashima | first5 = Y. | last6 = Sasaki | first6 = T. | last7 = Inoue | first7 = K. | last8 = Hes | first8 = O. | last9 = Michal | first9 = M. | title = Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects. | journal = Histol Histopathol | volume = 27 | issue = 11 | pages = 1407-12 | month = Nov | year = 2012 | doi =  | PMID = 23018240 }}</ref>


==Gross==
==Gross==
Line 49: Line 50:
*Cells arranged in nests.
*Cells arranged in nests.
*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref>
*Nuclei uniform and round.<ref name=Ref_GUP302>{{Ref GUP|302}}</ref>
**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''.
**Slightly enlarged nuclei, but '''no significant''' pleomorphism (size variation) - '''important'''.‡


Notes:
Notes:
*May look like eosinophilic variant of chromophobe RCC -- this is the main DDx.
*May look like eosinophilic variant of chromophobe RCC -- this is the main DDx.
**A comparison based on histomorphology: ''[[Kidney_tumours#Tabular_comparison_of_oncocytoma_and_chromophobe_RCC|Tabular comparison between ChRCC & oncocytoma]]''.
**A comparison based on histomorphology: ''[[Kidney_tumours#Tabular_comparison_of_oncocytoma_and_chromophobe_RCC|Tabular comparison between ChRCC & oncocytoma]]''.
***Oncocytoma typically has: no perinuclear clearing, no raisinoid nuclei, no binucleation.
***Oncocytoma typically has: no perinuclear clearing, no raisinoid nuclei, rare or no binucleation.
*May have - according to Trpkov ''et al.'':<ref name=pmid21166703>{{Cite journal  | last1 = Trpkov | first1 = K. | last2 = Yilmaz | first2 = A. | last3 = Uzer | first3 = D. | last4 = Dishongh | first4 = KM. | last5 = Quick | first5 = CM. | last6 = Bismar | first6 = TA. | last7 = Gokden | first7 = N. | title = Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. | journal = Histopathology | volume = 57 | issue = 6 | pages = 893-906 | month = Dec | year = 2010 | doi = 10.1111/j.1365-2559.2010.03726.x | PMID = 21166703 }}</ref>
**[[Vascular invasion]] ~4% of cases.
**Chromophobe-like foci (<5% of neoplasm) ~12% of cases.
**Focal clear cell changes ~15% of cases.
**Hemorrhage.
*‡ Focal "degenerative" atypia can be present; it is reported in ~20% of cases.<ref>{{cite journal |authors=Tickoo SK, Amin MB |title=Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis |journal=Am J Clin Pathol |volume=110 |issue=6 |pages=782–7 |date=December 1998 |pmid=9844591 |doi=10.1093/ajcp/110.6.782 |url=}}</ref>


DDx:
DDx:
*[[Chromophobe renal cell carcinoma]], eosinophilic variant.
*[[Chromophobe renal cell carcinoma]], eosinophilic variant.
*[[Succinate dehydrogenase-deficient renal cell carcinoma]] - emerging entity as per [[Vancouver classification]] - classically has a flocculent cytoplasm, may have oncocytoma-like areas.
*[[Papillary renal cell carcinoma]], oncocytic variant.
*[[Renal hybrid oncocytic/chromophobe tumour]].
*[[Clear cell renal cell carcinoma]], eosinophilic variant.
*[[Clear cell renal cell carcinoma]], eosinophilic variant.
*[[Tubulocystic carcinoma of the kidney]].
*Other [[renal tumours with eosinophilic cytoplasm]].
*Benign [[liver]].


===Images===
===Images===
====Case 1====
<gallery>
Image: Renal oncocytoma (3).jpg | Oncocytoma. (WC/KGH)
Image: Renal oncocytoma (1).jpg | Oncocytoma. (WC/KGH)
Image: Renal oncocytoma (2).jpg | Oncocytoma. (WC/KGH)
</gallery>
====Case 2====
<gallery>
<gallery>
Image:Renal_oncocytoma2.jpg | Oncocytoma - high mag. (WC/Nephron)
Image:Renal_oncocytoma2.jpg | Oncocytoma - high mag. (WC/Nephron)
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Image:Renal_oncocytoma4.jpg | Oncocytoma - low mag. (WC/Nephron)
Image:Renal_oncocytoma4.jpg | Oncocytoma - low mag. (WC/Nephron)
</gallery>
</gallery>
====Case 3====
<gallery>
Image:Renal oncocytoma -- low mag.jpg | Oncocytoma - low mag. (WC/Nephron)
Image:Renal oncocytoma - alt -- low mag.jpg | Oncocytoma - low mag. (WC/Nephron)
Image:Renal oncocytoma -- intermed mag.jpg | Oncocytoma - intermed. mag. (WC/Nephron)
Image:Renal oncocytoma -- high mag.jpg | Oncocytoma - high mag. (WC/Nephron)
</gallery>
==Stains==
==Stains==
*[[Hale's colloidal iron]] -ve.  
*[[Hale's colloidal iron]] (or [[Mueller-Mowry stain]]) -ve.  
**[[ChRCC]] +ve (blue granular cytoplasmic).
**[[ChRCC]] +ve (blue granular cytoplasmic).


==IHC==
==IHC==
*CK7 -ve<ref name=pmid17683191>{{Cite journal  | last1 = Liu | first1 = L. | last2 = Qian | first2 = J. | last3 = Singh | first3 = H. | last4 = Meiers | first4 = I. | last5 = Zhou | first5 = X. | last6 = Bostwick | first6 = DG. | title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 8 | pages = 1290-7 | month = Aug | year = 2007 | doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 | PMID = 17683191 }}</ref>/+ve (cytoplasmic) .
*[[CK7]] -ve<ref name=pmid17683191>{{Cite journal  | last1 = Liu | first1 = L. | last2 = Qian | first2 = J. | last3 = Singh | first3 = H. | last4 = Meiers | first4 = I. | last5 = Zhou | first5 = X. | last6 = Bostwick | first6 = DG. | title = Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. | journal = Arch Pathol Lab Med | volume = 131 | issue = 8 | pages = 1290-7 | month = Aug | year = 2007 | doi = 10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2 | PMID = 17683191 }}</ref>/+ve (cytoplasmic).
**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.
**[[Chromophobe renal cell carcinoma]] = cell membrane +ve.
**Based on a mRNA study it was suggested that <50% CK7 immunostaining favours oncocytoma.<ref name=pmid16927643>{{Cite journal  | last1 = Adley | first1 = BP. | last2 = Papavero | first2 = V. | last3 = Sugimura | first3 = J. | last4 = Teh | first4 = BT. | last5 = Yang | first5 = XJ. | title = Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. | journal = Anal Quant Cytol Histol | volume = 28 | issue = 4 | pages = 228-36 | month = Aug | year = 2006 | doi =  | PMID = 16927643 }}</ref>
*PAX8 +ve.<ref name=pmid22135028>{{Cite journal  | last1 = Hu | first1 = Y. | last2 = Hartmann | first2 = A. | last3 = Stoehr | first3 = C. | last4 = Zhang | first4 = S. | last5 = Wang | first5 = M. | last6 = Tacha | first6 = D. | last7 = Montironi | first7 = R. | last8 = Lopez-Beltran | first8 = A. | last9 = Cheng | first9 = L. | title = PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody. | journal = J Clin Pathol | volume = 65 | issue = 3 | pages = 254-6 | month = Mar | year = 2012 | doi = 10.1136/jclinpath-2011-200508 | PMID = 22135028 }}</ref>
*[[CD117]] +ve.<ref>{{Cite journal  | last1 = Krüger | first1 = S. | last2 = Sotlar | first2 = K. | last3 = Kausch | first3 = I. | last4 = Horny | first4 = HP. | title = Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma. | journal = Oncology | volume = 68 | issue = 2-3 | pages = 269-75 | month =  | year = 2005 | doi = 10.1159/000086783 | PMID = 16015044 }}</ref>
**ChRCC also +ve.
*GATA-3 usually -ve (38 cases negative of 47 cases).<ref name=pmid2431520>{{cite journal |authors=Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ |title=Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms |journal=Hum Pathol |volume=45 |issue=2 |pages=244–8 |date=February 2014 |pmid=24315206 |doi=10.1016/j.humpath.2013.08.020 |url=}}</ref>
**+ve in [[low-grade oncocytic renal tumour]].


*PAX2 +ve .<ref name=pmid17210525>{{cite journal |author=Memeo L, Jhang J, Assaad AM, ''et al.'' |title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma |journal=Am. J. Clin. Pathol. |volume=127 |issue=2 |pages=225–9 |year=2007 |month=February |pmid=17210525 |doi=10.1309/9KWEA4W9Y94D1AEE |url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>
Others:
*CD10 -ve/+ve.
*Amylase α-1A +ve.<ref name=pmid24225843>{{Cite journal  | last1 = Jain | first1 = S. | last2 = Roy | first2 = S. | last3 = Amin | first3 = M. | last4 = Acquafondata | first4 = M. | last5 = Yin | first5 = M. | last6 = Laframboise | first6 = W. | last7 = Bastacky | first7 = S. | last8 = Pantanowitz | first8 = L. | last9 = Dhir | first9 = R. | title = Amylase α-1A (AMY1A): A Novel Immunohistochemical Marker to Differentiate Chromophobe Renal Cell Carcinoma From Benign Oncocytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 12 | pages = 1824-30 | month = Dec | year = 2013 | doi = 10.1097/PAS.0000000000000108 | PMID = 24225843 }}</ref>
*PAX2 +ve.<ref name=pmid17210525>{{cite journal |author=Memeo L, Jhang J, Assaad AM, ''et al.'' |title=Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma |journal=Am. J. Clin. Pathol. |volume=127 |issue=2 |pages=225–9 |year=2007 |month=February |pmid=17210525 |doi=10.1309/9KWEA4W9Y94D1AEE |url=http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525}}</ref>
**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
**Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
*AMACR -ve<ref name=pmid26925847>{{Cite journal  | last1 = Lüders | first1 = C. | last2 = Kristiansen | first2 = G. | title = [Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?]. | journal = Pathologe | volume = 37 | issue = 2 | pages = 153-8 | month = Mar | year = 2016 | doi = 10.1007/s00292-016-0145-0 | PMID = 26925847 }}</ref> or variable.<ref>{{Cite journal  | last1 =  Wobker | first1 = S.E.| last2 = Williamson | first2 = S.R. | title = Modern Pathologic Diagnosis of Renal Oncocytoma | journal = J Kidney Cancer VHL | volume = 4 | issue = 4 | pages = 1-12 | month = Oct | year = 2017 | doi = 10.15586/jkcvhl.2017.96 | PMID = 29090117}}</ref>
*Vimentin -ve.<ref name=pmid26925847/>


*Amylase α-1A +ve.<ref name=pmid24225843>{{Cite journal  | last1 = Jain | first1 = S. | last2 = Roy | first2 = S. | last3 = Amin | first3 = M. | last4 = Acquafondata | first4 = M. | last5 = Yin | first5 = M. | last6 = Laframboise | first6 = W. | last7 = Bastacky | first7 = S. | last8 = Pantanowitz | first8 = L. | last9 = Dhir | first9 = R. | title = Amylase α-1A (AMY1A): A Novel Immunohistochemical Marker to Differentiate Chromophobe Renal Cell Carcinoma From Benign Oncocytoma. | journal = Am J Surg Pathol | volume = 37 | issue = 12 | pages = 1824-30 | month = Dec | year = 2013 | doi = 10.1097/PAS.0000000000000108 | PMID = 24225843 }}</ref>
A panel:
*CK7, PAX8, CD117, CD10, [[Mueller-Mowry stain]], GATA-3.
 
===Comparison between some renal tumours with eosinophilic cytoplasm===
{| class="wikitable sortable"
!Tumour
![[CK7]]
![[CD117]]
![[GATA3]]
|-
| Renal oncocytoma
| -ve †
| +ve
| -ve/+ve
|-
| [[Chromophobe renal cell carcinoma]]
| +ve ‡
| +ve
| -ve
|-
| [[Low-grade oncocytic tumour]]
| +ve
| -ve
| +ve
|-
|}
† may have scattered positive cells<br>
‡ diffuse and strong


==Sign out==
==Sign out==
===Biopsy===
<pre>
<pre>
PORTION OF KIDNEY, RIGHT, PARTIAL NEPHRECTOMY:
Kidney Mass, Left, Core Biopsy:
- Renal tumour with oncocytic cytoplasm, favour oncocytoma.
 
COMMENT:
The tumour is stains as follows:
POSITIVE: CD117.
NEGATIVE: Hale's colloidal iron, CK7.
</pre>
 
====Block letters====
<pre>
KIDNEY MASS, RIGHT, CORE BIOPSY:
- RENAL TUMOUR WITH ONCOCYTIC CYTOPLASM, FAVOUR ONCOCYTOMA.
 
COMMENT:
The tumour is CK7 negative and Hale's colloidal iron negative.
</pre>
 
====Micro====
The sections show a tumour with cells arranged in nests. The tumour cells have abundant
eosinophilic cytoplasm. The tumour cell nuclei are predominantly round. No perinuclear
halos are apparent. Binucleation is not common. No zonal necrosis is identified.  Focally,
tumour nests are spaced reminiscent of an archipelago. Mitoses are not apparent.  The
tumour is moderately circumscribed.
 
A small amount of renal parenchyma is present. No definite glomeruli are identified. No
significant interstitial fibrosis is present.  No inflammation is apparent.
 
===Resection===
<pre>
PORTION OF KIDNEY, LEFT, PARTIAL NEPHRECTOMY:
- ONCOCYTOMA.
- ONCOCYTOMA.
COMMENT:
The tumour is CK7 negative and Hale's colloidal iron negative.
</pre>
</pre>


===Micro===
====Micro====
The sections show a tumour with cells arranged in nests. The tumour cells have abundant
The sections show a tumour with cells arranged in nests. The tumour cells have abundant
eosinophilic cytoplasm. The tumour cell nuclei are round and have round nucleoli. No
eosinophilic cytoplasm. The tumour cell nuclei are round and have round nucleoli. No
perinuclear halos are apparent. Binucleation is not apparent. No zonal necrosis is
perinuclear halos are apparent. Binucleation is not common. No zonal necrosis is
identified. Focally, tumour nests are spaced reminiscent of an archipelago. Mitoses are not
identified. Focally, tumour nests are spaced reminiscent of an archipelago. Mitoses are not
apparent. The tumour is moderately circumscribed.
apparent. The tumour is moderately circumscribed and is completely excised in the planes of
section.
 
The thin rim of renal parenchyma has no apparent glomerular pathology on the H&E stained
sections.  Mild-to-moderate atherosclerosis is present. Mild arteriolar hyalinization is
identified.


The thin rim of renal parenchyma has no apparent pathology on the H&E stained sections.
The Hale's colloidal iron stain is negative in the tumour. A CK7 immunostain has very rare positive cells within the tumour; this is interpreted overall as negative.


==See also==
==See also==

Latest revision as of 13:41, 19 June 2024

Renal oncocytoma
Diagnosis in short

Renal oncocytoma (left of image) and normal kidney (right of image). Kidney biopsy. H&E stain.
LM abundant eosinophilic cytoplasm - slightly granular, cells arranged in nests, nuclei uniform and round without significant pleomorphism
LM DDx chromophobe renal cell carcinoma eosinophilic variant, clear cell renal cell carcinoma eosinophilic variant, papillary renal cell carcinoma oncocytic variant, tubulocystic carcinoma of the kidney, other renal tumours with eosinophilic cytoplasm, benign liver
Stains Hale's colloidal iron -ve
IHC CK7 -ve/cytoplasmic +ve, CD117 +ve, PAX8 +ve
EM abundant mitochondria
Gross mass, mahogany brown +/- central scar
Grossing notes partial nephrectomy grossing, total nephrectomy for tumour grossing
Site kidney - see kidney tumours
Clinical history often incidentally discovered mass
Radiology renal mass with central scar (classic)
Prognosis benign
Clin. DDx other kidney tumours

Renal oncocytoma is a benign kidney tumour that is removed to exclude malignancy.

General

  • Can be difficult to distinguish radiologically from RCC (chromophobe subtype).
    • ... and pathologists occasionally struggle like the radiologists.
  • Benign tumour - the reason it is excised is... one cannot be certain it isn't a RCC.
  • May be seen in the context of renal oncocytosis.[1]

Gross

  • Mass, mahogany brown.
    • Well circumscribed.
    • 1/3 have a characteristic central scar.[2]

Image

  • Renal oncocytoma with central scar. (WP)

Microscopic

Features:

  • Eosinophilic cytoplasm - slightly granular key feature.
  • Cells arranged in nests.
  • Nuclei uniform and round.[2]
    • Slightly enlarged nuclei, but no significant pleomorphism (size variation) - important.‡

Notes:

  • May look like eosinophilic variant of chromophobe RCC -- this is the main DDx.
  • May have - according to Trpkov et al.:[3]
    • Vascular invasion ~4% of cases.
    • Chromophobe-like foci (<5% of neoplasm) ~12% of cases.
    • Focal clear cell changes ~15% of cases.
    • Hemorrhage.
  • ‡ Focal "degenerative" atypia can be present; it is reported in ~20% of cases.[4]

DDx:

Images

Case 1

  • Oncocytoma. (WC/KGH)

  • Oncocytoma. (WC/KGH)

  • Oncocytoma. (WC/KGH)

Case 2

  • Oncocytoma - high mag. (WC/Nephron)

  • Oncocytoma - intermed. mag. (WC/Nephron)

  • Oncocytoma - low mag. (WC/Nephron)

Case 3

  • Oncocytoma - low mag. (WC/Nephron)

  • Oncocytoma - low mag. (WC/Nephron)

  • Oncocytoma - intermed. mag. (WC/Nephron)

  • Oncocytoma - high mag. (WC/Nephron)

Stains

IHC

Others:

  • CD10 -ve/+ve.
  • Amylase α-1A +ve.[10]
  • PAX2 +ve.[11]
    • Oncocytoma 20 of 23 +ve versus ChRCC 1 of 11 +ve.
  • AMACR -ve[12] or variable.[13]
  • Vimentin -ve.[12]

A panel:

Comparison between some renal tumours with eosinophilic cytoplasm

Tumour CK7 CD117 GATA3
Renal oncocytoma -ve † +ve -ve/+ve
Chromophobe renal cell carcinoma +ve ‡ +ve -ve
Low-grade oncocytic tumour +ve -ve +ve

† may have scattered positive cells
‡ diffuse and strong

Sign out

Biopsy

Kidney Mass, Left, Core Biopsy:
- Renal tumour with oncocytic cytoplasm, favour oncocytoma.

COMMENT:
The tumour is stains as follows:
POSITIVE: CD117.
NEGATIVE: Hale's colloidal iron, CK7.

Block letters

KIDNEY MASS, RIGHT, CORE BIOPSY:
- RENAL TUMOUR WITH ONCOCYTIC CYTOPLASM, FAVOUR ONCOCYTOMA.

COMMENT:
The tumour is CK7 negative and Hale's colloidal iron negative.

Micro

The sections show a tumour with cells arranged in nests. The tumour cells have abundant eosinophilic cytoplasm. The tumour cell nuclei are predominantly round. No perinuclear halos are apparent. Binucleation is not common. No zonal necrosis is identified. Focally, tumour nests are spaced reminiscent of an archipelago. Mitoses are not apparent. The tumour is moderately circumscribed.

A small amount of renal parenchyma is present. No definite glomeruli are identified. No significant interstitial fibrosis is present. No inflammation is apparent.

Resection

PORTION OF KIDNEY, LEFT, PARTIAL NEPHRECTOMY:
- ONCOCYTOMA.

COMMENT:
The tumour is CK7 negative and Hale's colloidal iron negative.

Micro

The sections show a tumour with cells arranged in nests. The tumour cells have abundant eosinophilic cytoplasm. The tumour cell nuclei are round and have round nucleoli. No perinuclear halos are apparent. Binucleation is not common. No zonal necrosis is identified. Focally, tumour nests are spaced reminiscent of an archipelago. Mitoses are not apparent. The tumour is moderately circumscribed and is completely excised in the planes of section.

The thin rim of renal parenchyma has no apparent glomerular pathology on the H&E stained sections. Mild-to-moderate atherosclerosis is present. Mild arteriolar hyalinization is identified.

The Hale's colloidal iron stain is negative in the tumour. A CK7 immunostain has very rare positive cells within the tumour; this is interpreted overall as negative.

See also

References

  1. ↑ Kuroda, N.; Tanaka, A.; Ohe, C.; Mikami, S.; Nagashima, Y.; Sasaki, T.; Inoue, K.; Hes, O. et al. (Nov 2012). "Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects.". Histol Histopathol 27 (11): 1407-12. PMID 23018240.
  2. ↑ 2.0 2.1 Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 302. ISBN 978-0443066771.
  3. ↑ Trpkov, K.; Yilmaz, A.; Uzer, D.; Dishongh, KM.; Quick, CM.; Bismar, TA.; Gokden, N. (Dec 2010). "Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features.". Histopathology 57 (6): 893-906. doi:10.1111/j.1365-2559.2010.03726.x. PMID 21166703.
  4. ↑ Tickoo SK, Amin MB (December 1998). "Discriminant nuclear features of renal oncocytoma and chromophobe renal cell carcinoma. Analysis of their potential utility in the differential diagnosis". Am J Clin Pathol 110 (6): 782–7. doi:10.1093/ajcp/110.6.782. PMID 9844591.
  5. ↑ Liu, L.; Qian, J.; Singh, H.; Meiers, I.; Zhou, X.; Bostwick, DG. (Aug 2007). "Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis.". Arch Pathol Lab Med 131 (8): 1290-7. doi:10.1043/1543-2165(2007)131[1290:IAOCRC]2.0.CO;2. PMID 17683191.
  6. ↑ Adley, BP.; Papavero, V.; Sugimura, J.; Teh, BT.; Yang, XJ. (Aug 2006). "Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma.". Anal Quant Cytol Histol 28 (4): 228-36. PMID 16927643.
  7. ↑ Hu, Y.; Hartmann, A.; Stoehr, C.; Zhang, S.; Wang, M.; Tacha, D.; Montironi, R.; Lopez-Beltran, A. et al. (Mar 2012). "PAX8 is expressed in the majority of renal epithelial neoplasms: an immunohistochemical study of 223 cases using a mouse monoclonal antibody.". J Clin Pathol 65 (3): 254-6. doi:10.1136/jclinpath-2011-200508. PMID 22135028.
  8. ↑ Krüger, S.; Sotlar, K.; Kausch, I.; Horny, HP. (2005). "Expression of KIT (CD117) in renal cell carcinoma and renal oncocytoma.". Oncology 68 (2-3): 269-75. doi:10.1159/000086783. PMID 16015044.
  9. ↑ Gonzalez-Roibon N, Faraj SF, Munari E, Bezerra SM, Albadine R, Sharma R, Argani P, Allaf ME, Netto GJ (February 2014). "Comprehensive profile of GATA binding protein 3 immunohistochemical expression in primary and metastatic renal neoplasms". Hum Pathol 45 (2): 244–8. doi:10.1016/j.humpath.2013.08.020. PMID 24315206.
  10. ↑ Jain, S.; Roy, S.; Amin, M.; Acquafondata, M.; Yin, M.; Laframboise, W.; Bastacky, S.; Pantanowitz, L. et al. (Dec 2013). "Amylase α-1A (AMY1A): A Novel Immunohistochemical Marker to Differentiate Chromophobe Renal Cell Carcinoma From Benign Oncocytoma.". Am J Surg Pathol 37 (12): 1824-30. doi:10.1097/PAS.0000000000000108. PMID 24225843.
  11. ↑ Memeo L, Jhang J, Assaad AM, et al. (February 2007). "Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma". Am. J. Clin. Pathol. 127 (2): 225–9. doi:10.1309/9KWEA4W9Y94D1AEE. PMID 17210525. http://ajcp.ascpjournals.org/cgi/pmidlookup?view=long&pmid=17210525.
  12. ↑ 12.0 12.1 Lüders, C.; Kristiansen, G. (Mar 2016). "[Oncocytoma versus chromophobe renal cell carcinoma : Is there something in between?].". Pathologe 37 (2): 153-8. doi:10.1007/s00292-016-0145-0. PMID 26925847.
  13. ↑ Wobker, S.E.; Williamson, S.R. (Oct 2017). "Modern Pathologic Diagnosis of Renal Oncocytoma". J Kidney Cancer VHL 4 (4): 1-12. doi:10.15586/jkcvhl.2017.96. PMID 29090117.
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