Difference between revisions of "Thrombotic thrombocytopenic purpura"
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'''Thrombotic thrombocytopenic purpura''' is a type of [[thrombotic microangiopathy]]. | '''Thrombotic thrombocytopenic purpura''', abbreviated '''TTP''', is a type of [[thrombotic microangiopathy]]. | ||
==Classic pentad== | ==Classic pentad== | ||
| Line 5: | Line 5: | ||
#Fever. | #Fever. | ||
#Thrombocytopenia. | #Thrombocytopenia. | ||
#Microangiopathic hemolytic anemia. | #Microangiopathic hemolytic [[anemia]]. | ||
#*Usu. with schistocytes (fragmented [[RBC]]s).<ref>{{Ref Klatt|65}}</ref> | |||
#Transient neurologic symptoms. | #Transient neurologic symptoms. | ||
#Renal failure. | #Renal failure. | ||
===Mnemonic=== | ===Mnemonic=== | ||
''HUS/TTP is a CRAFTY syndrome'':<ref>URL: [http://www.valuemd.com/mnemonics2.php http://www.valuemd.com/mnemonics2.php]. Accessed on: 8 November 2010.</ref> | ''[[HUS]]/TTP is a CRAFTY syndrome'':<ref>URL: [http://www.valuemd.com/mnemonics2.php http://www.valuemd.com/mnemonics2.php]. Accessed on: 8 November 2010.</ref> | ||
*'''C'''NS symptoms. | *'''C'''NS symptoms. | ||
*'''R'''enal failure. | *'''R'''enal failure. | ||
| Line 16: | Line 17: | ||
*'''F'''ever. | *'''F'''ever. | ||
*'''T'''hrombocytopenia. | *'''T'''hrombocytopenia. | ||
*'''Y''' - no one knows "Y" it occurs. | *'''Y''' - no one knows "Y" it occurs. | ||
==Etiology== | ==Etiology== | ||
Deficiency of ''ADAMTS13'' which may be:<ref name=Ref_PBoD8_669>{{Ref PBoD8|669}}</ref> | Deficiency of plasma enzyme ''ADAMTS13'' which may be:<ref name=Ref_PBoD8_669>{{Ref PBoD8|669}}</ref> | ||
*Inherited. | *Inherited. | ||
*Acquired (autoantibodies). | *Acquired (autoantibodies). | ||
| Line 25: | Line 26: | ||
==See also== | ==See also== | ||
*[[Vasculitides]]. | *[[Vasculitides]]. | ||
*[[Hemolytic uremic syndrome]]. | |||
*[[Medical renal diseases]]. | *[[Medical renal diseases]]. | ||
*[[Anemia]]. | |||
==References== | ==References== | ||
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[[Category:Cardiovascular pathology]] | [[Category:Cardiovascular pathology]] | ||
[[Category:Diagnosis]] | |||
Latest revision as of 01:01, 28 February 2012
Thrombotic thrombocytopenic purpura, abbreviated TTP, is a type of thrombotic microangiopathy.
Classic pentad
It was classically described as the pentad of:[1]
- Fever.
- Thrombocytopenia.
- Microangiopathic hemolytic anemia.
- Transient neurologic symptoms.
- Renal failure.
Mnemonic
HUS/TTP is a CRAFTY syndrome:[3]
- CNS symptoms.
- Renal failure.
- Anemia - microangiopathic hemolytic anemia.
- Fever.
- Thrombocytopenia.
- Y - no one knows "Y" it occurs.
Etiology
Deficiency of plasma enzyme ADAMTS13 which may be:[1]
- Inherited.
- Acquired (autoantibodies).
See also
References
- ↑ 1.0 1.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 669. ISBN 978-1416031215.
- ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 65. ISBN 978-1416002741.
- ↑ URL: http://www.valuemd.com/mnemonics2.php. Accessed on: 8 November 2010.