Alveolar soft part sarcoma: Difference between revisions
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| Caption = ASPS. [[H&E stain]]. | | Caption = ASPS. [[H&E stain]]. | ||
| Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in | | Micro = large cells (~30-50 μm) with abundant eosinophilic cytoplasm and an eccentric nucleus +/-nucleolus, arranged in nests/separated by thin septa - vaguely resembles alveoli (at low power) | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[paraganglioma]], [[clear cell renal cell carcinoma]], [[alveolar rhabdomyosarcoma]] | | LMDDx = [[paraganglioma]], [[clear cell renal cell carcinoma]], [[alveolar rhabdomyosarcoma]] | ||
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| ClinDDx = | | ClinDDx = | ||
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'''Alveolar soft part sarcoma''', abbreviated '''ASPS''', is a rare malignant soft tissue lesion typically seen in younger individuals. | '''Alveolar soft part sarcoma''', abbreviated '''ASPS''', is a rare [[malignant]] soft tissue lesion typically seen in younger individuals. | ||
==General== | ==General== | ||
*Adolescents/young adults. | *Adolescents/young adults. | ||
*Children -- classically location: base of [[tongue]] | *Children -- classically location: orbit and base of [[tongue]].<ref name=pmid21934227>{{Cite journal | last1 = Anbarasi | first1 = K. | last2 = Sathasivasubramanian | first2 = S. | last3 = Kuruvilla | first3 = S. | title = Alveolar soft-part sarcoma of tongue. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 3 | pages = 581-3 | month = | year = | doi = 10.4103/0377-4929.85099 | PMID = 21934227 }}</ref> | ||
*Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal | last1 = Folpe | first1 = AL. | last2 = Deyrup | first2 = AT. | title = Alveolar soft-part sarcoma: a review and update. | journal = J Clin Pathol | volume = 59 | issue = 11 | pages = 1127-32 | month = Nov | year = 2006 | doi = 10.1136/jcp.2005.031120 | PMID = 17071801 |PMC = 1860509 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref> | *Typical indolent initially - ultimately a poor prognosis.<ref name=pmid17071801>{{Cite journal | last1 = Folpe | first1 = AL. | last2 = Deyrup | first2 = AT. | title = Alveolar soft-part sarcoma: a review and update. | journal = J Clin Pathol | volume = 59 | issue = 11 | pages = 1127-32 | month = Nov | year = 2006 | doi = 10.1136/jcp.2005.031120 | PMID = 17071801 |PMC = 1860509 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860509/?tool=pubmed }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | Features:<ref name=Ref_WMSP627>{{Ref WMSP|627}}</ref> | ||
*Arranged in | *Arranged in nests/separated by thin septa; vaguely resembles alveoli (at low power). | ||
*Large cells (~30-50 μm) with abundant eosinophilic cytoplasm. | *Large cells (~30-50 μm) with abundant eosinophilic cytoplasm. | ||
**May be focally cleared. | **May be focally cleared. | ||