Difference between revisions of "Serous borderline tumour"

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#redirect [[Ovarian tumours#Ovarian serous borderline tumour]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Serous borderline tumour with micropapillary pattern -- intermed mag.jpg
| Width      =
| Caption    = Serous borderline tumour with a micropapillary pattern. [[H&E stain]].
| Synonyms  =
| Micro      = cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-[[psammoma bodies]], +/-micropapillary architecture (often described as a ''medusa head'' pattern)
| Subtypes  = serous borderline tumour (SBT) with micropapillary pattern, typical SBT ''or'' SBT not otherwise specified
| LMDDx      = [[serous cystadenoma of the ovary|serous cystadenoma]], [[serous carcinoma of the ovary]], [[clear cell carcinoma of the ovary]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[ovary]], [[uterine tube]] - see ''[[ovarian tumours]]''
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = usually benign, need follow-up
| Other      =
| ClinDDx    = other [[ovarian tumours]] (benign and malignant)
| Tx        = excision, follow-up
}}
'''Serous borderline tumour''' is a Muellerian epithelial [[ovarian tumour]] with a behaviour that borders on [[malignant]].
 
It is also known as '''serous tumour of low malignant potential''', abbreviated ''SLMP''.<ref name=pmid10836293>{{Cite journal  | last1 = Seidman | first1 = JD. | last2 = Kurman | first2 = RJ. | title = Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators. | journal = Hum Pathol | volume = 31 | issue = 5 | pages = 539-57 | month = May | year = 2000 | doi =  | PMID = 10836293 }}</ref><ref name=pmid10881733>{{Cite journal  | last1 = Dietel | first1 = M. | last2 = Hauptmann | first2 = S. | title = Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology. | journal = Virchows Arch | volume = 436 | issue = 5 | pages = 403-12 | month = May | year = 2000 | doi =  | PMID = 10881733 }}</ref>
 
''Serous ovarian tumour of low malignant potential'' redirects here.<ref name=pmid10881733/>
 
==General==
*Usually benign.
*Require long term follow-up.
 
==Microscopic==
Features:<ref name=Ref_GP399>{{Ref GP|399}}</ref>
*Cuboidal to columnar epithelium with mild to moderate atypia.
*Non-invasive.
*"Sparse" mitoses.
*+/-[[Psammoma bodies]].
*+/-Micropapillary architecture - often described as a ''medusa head'' pattern.
 
DDx:
*[[Serous carcinoma of the ovary]] - focus a with stromal invasion >5mm (linear measurement) ''or'' > 10 mm<sup>2</sup> (area).<ref name=Ref_GP399>{{Ref GP|399}}</ref>
**Invasive cells are "pink", i.e. have abundant eosinophilic cytoplasm,<ref name=Ref_GP399/>; also, cells usu. large (~2-3x size of non-invasive component), and typically have an enlarged nucleus (~2x non-invasive component).
*[[Clear cell carcinoma of the ovary]] - classically associated with [[endometriosis]], have simpler, smaller papillae without branching.
*[[Serous cystadenoma of the ovary]].
 
===Images===
<gallery>
Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg -- very very low mag.jpg | SBTMP - very very low mag.
Image: Serous borderline tumour with micropapillary pattern -- very low mag.jpg | SBTMP - very low mag.
Image: Serous borderline tumour with micropapillary pattern -- low mag.jpg | SBTMP - low mag.
Image: Serous borderline tumour with micropapillary pattern -- intermed mag.jpg | SBTMP - intermed. mag.
Image: Serous borderline tumour with micropapillary pattern -- high mag.jpg | SBTMP - high mag.
 
Image: Serous borderline tumour with micropapillary pattern - a -- very low mag.jpg | SBTMP - very low mag.
Image: Serous borderline tumour with micropapillary pattern - a -- low mag.jpg | SBTMP - low mag.
Image: Serous borderline tumour with micropapillary pattern - a -- intermed mag.jpg | SBTMP - intermed. mag.
Image: Serous borderline tumour with micropapillary pattern - a -- high mag.jpg | SBTMP - high mag.
Image: Serous borderline tumour with micropapillary pattern - a2 -- high mag.jpg | SBTMP - high mag.
Image: Serous borderline tumour with micropapillary pattern - a3 -- high mag.jpg | SBTMP - high mag.
Image: Serous borderline tumour with micropapillary pattern - a -- very high mag.jpg | SBTMP - very high mag.
</gallery>
====www====
*[http://pubs.rsna.org/na101/home/literatum/publisher/rsna/journals/content/radiographics/2005/radiographics.2005.25.issue-6/rg.256055015/production/images/medium/g05nv16c4x.jpeg Serous ovarian LMP tumour (radiographics.rsna.org)].<ref name=pmid16284143>{{Cite journal  | last1 = Burkholz | first1 = KJ. | last2 = Wood | first2 = BP. | last3 = Zuppan | first3 = C. | title = Best cases from the AFIP: Borderline papillary serous tumor of the right ovary. | journal = Radiographics | volume = 25 | issue = 6 | pages = 1689-92 | month =  | year =  | doi = 10.1148/rg.256055015 | PMID = 16284143 }}</ref>
 
===Subclassification===
Typical subdivided into:<ref name=pmid21917305>{{Cite journal  | last1 = Park | first1 = JY. | last2 = Kim | first2 = DY. | last3 = Kim | first3 = JH. | last4 = Kim | first4 = YM. | last5 = Kim | first5 = KR. | last6 = Kim | first6 = YT. | last7 = Nam | first7 = JH. | title = Micropapillary pattern in serous borderline ovarian tumors: does it matter? | journal = Gynecol Oncol | volume = 123 | issue = 3 | pages = 511-6 | month = Dec | year = 2011 | doi = 10.1016/j.ygyno.2011.08.008 | PMID = 21917305 }}</ref>
*Micropapillary serous borderline tumour.
*Typical serous borderline tumour (SBOT).
 
==Sign out==
<pre>
Cyst and Right Fallopian Tube, Excision:
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
- Fallopian tube within normal limits.
- NEGATIVE for evidence of invasion.
 
Comment:
The lesion appears to be confined to a cystic structure.
</pre>
 
==See also==
*[[Ovarian tumours]].
 
==References==
{{Reflist|1}}
 
[[Category:Diagnosis]]
[[Category:Ovarian tumours]]

Latest revision as of 11:25, 29 March 2016

Serous borderline tumour
Diagnosis in short

Serous borderline tumour with a micropapillary pattern. H&E stain.

LM cuboidal to columnar epithelium with mild to moderate atypia, no invasion (see below), "sparse" mitoses ,+/-psammoma bodies, +/-micropapillary architecture (often described as a medusa head pattern)
Subtypes serous borderline tumour (SBT) with micropapillary pattern, typical SBT or SBT not otherwise specified
LM DDx serous cystadenoma, serous carcinoma of the ovary, clear cell carcinoma of the ovary
Site ovary, uterine tube - see ovarian tumours

Prevalence uncommon
Prognosis usually benign, need follow-up
Clin. DDx other ovarian tumours (benign and malignant)
Treatment excision, follow-up

Serous borderline tumour is a Muellerian epithelial ovarian tumour with a behaviour that borders on malignant.

It is also known as serous tumour of low malignant potential, abbreviated SLMP.[1][2]

Serous ovarian tumour of low malignant potential redirects here.[2]

General

  • Usually benign.
  • Require long term follow-up.

Microscopic

Features:[3]

  • Cuboidal to columnar epithelium with mild to moderate atypia.
  • Non-invasive.
  • "Sparse" mitoses.
  • +/-Psammoma bodies.
  • +/-Micropapillary architecture - often described as a medusa head pattern.

DDx:

Images

www

Subclassification

Typical subdivided into:[5]

  • Micropapillary serous borderline tumour.
  • Typical serous borderline tumour (SBOT).

Sign out

Cyst and Right Fallopian Tube, Excision:
- SEROUS BORDERLINE TUMOUR with micropapillary architecture, see comment.
- Fallopian tube within normal limits.
- NEGATIVE for evidence of invasion.

Comment:
The lesion appears to be confined to a cystic structure.

See also

References

  1. Seidman, JD.; Kurman, RJ. (May 2000). "Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.". Hum Pathol 31 (5): 539-57. PMID 10836293.
  2. 2.0 2.1 Dietel, M.; Hauptmann, S. (May 2000). "Serous tumors of low malignant potential of the ovary. 1. Diagnostic pathology.". Virchows Arch 436 (5): 403-12. PMID 10881733.
  3. 3.0 3.1 3.2 Nucci, Marisa R.; Oliva, Esther (2009). Gynecologic Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 399. ISBN 978-0443069208.
  4. Burkholz, KJ.; Wood, BP.; Zuppan, C.. "Best cases from the AFIP: Borderline papillary serous tumor of the right ovary.". Radiographics 25 (6): 1689-92. doi:10.1148/rg.256055015. PMID 16284143.
  5. Park, JY.; Kim, DY.; Kim, JH.; Kim, YM.; Kim, KR.; Kim, YT.; Nam, JH. (Dec 2011). "Micropapillary pattern in serous borderline ovarian tumors: does it matter?". Gynecol Oncol 123 (3): 511-6. doi:10.1016/j.ygyno.2011.08.008. PMID 21917305.