Difference between revisions of "Atrophic prostate carcinoma"

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#redirect [[Prostate_gland#Atrophic_prostate_carcinoma]]
'''Atrophic prostate carcinoma''' is a type of [[prostate cancer]] that typically co-exists with conventional (acinar) prostate carcinoma. As its name implies, it has atrophic changes and can mimic (benign) [[prostate with atrophic changes]].
 
==General==
*Uncommon.
 
Note:
*An atrophic component in prostate cancer is common; one study identified it in ~15% of cases.<ref name=pmid9620026>{{Cite journal  | last1 = Kaleem | first1 = Z. | last2 = Swanson | first2 = PE. | last3 = Vollmer | first3 = RT. | last4 = Humphrey | first4 = PA. | title = Prostatic adenocarcinoma with atrophic features: a study of 202 consecutive completely embedded radical prostatectomy specimens. | journal = Am J Clin Pathol | volume = 109 | issue = 6 | pages = 695-703 | month = Jun | year = 1998 | doi =  | PMID = 9620026 }}</ref>
 
==Microscopic==
Features:
*Scant cytoplasm.
*Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
*+/-Increased gland density.
 
DDx:
*[[Atrophy of the prostate]].
 
===Images===
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f12.html#figure-title Atrophic carcinoma (nature.com)].
 
==IHC==
*p63 -ve.
**Rare p63 +ve prostate carcinoma is reported.<ref name=pmid23991727>{{Cite journal  | last1 = Wu | first1 = A. | last2 = Kunju | first2 = LP. | title = Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics. | journal = Arch Pathol Lab Med | volume = 137 | issue = 9 | pages = 1179-84 | month = Sep | year = 2013 | doi = 10.5858/arpa.2013-0254-CR | PMID = 23991727 }}</ref>
 
==See also==
*[[Prostate carcinoma]].
 
==References==
{{Reflist|1}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Genitourinary pathology]]

Latest revision as of 06:40, 17 November 2014

Atrophic prostate carcinoma is a type of prostate cancer that typically co-exists with conventional (acinar) prostate carcinoma. As its name implies, it has atrophic changes and can mimic (benign) prostate with atrophic changes.

General

  • Uncommon.

Note:

  • An atrophic component in prostate cancer is common; one study identified it in ~15% of cases.[1]

Microscopic

Features:

  • Scant cytoplasm.
  • Nuclear features of conventional prostate cancer (nucleoli, nuclear enlargement).
  • +/-Increased gland density.

DDx:

Images

IHC

  • p63 -ve.
    • Rare p63 +ve prostate carcinoma is reported.[2]

See also

References

  1. Kaleem, Z.; Swanson, PE.; Vollmer, RT.; Humphrey, PA. (Jun 1998). "Prostatic adenocarcinoma with atrophic features: a study of 202 consecutive completely embedded radical prostatectomy specimens.". Am J Clin Pathol 109 (6): 695-703. PMID 9620026.
  2. Wu, A.; Kunju, LP. (Sep 2013). "Prostate cancer with aberrant diffuse p63 expression: report of a case and review of the literature and morphologic mimics.". Arch Pathol Lab Med 137 (9): 1179-84. doi:10.5858/arpa.2013-0254-CR. PMID 23991727.