Cushing syndrome: Difference between revisions
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Jensflorian (talk | contribs) →Microscopic: +pictures crooke cell adenoma |
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==Clinical== | ==Clinical== | ||
The features can be remembered with ''CUSHING'':<ref>URL: [http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html]. Accessed on: 1 May 2012.</ref> | The features can be remembered with ''CUSHING'':<ref>URL: [http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html]. Accessed on: 1 May 2012.</ref> | ||
*'''C'''entral obesity + '''C'''ervical fat pad. | *'''C'''entral obesity + '''C'''ervical fat pad + '''C'''omedones (acne). | ||
*'''U'''nusual brUising. | *'''U'''nusual brUising. | ||
*'''S'''triae. | *'''S'''triae. | ||
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A shorter version is ''CUSH'': | A shorter version is ''CUSH'': | ||
*'''C'''entral | *'''C'''entral obesity with peripheral wasting, '''C'''ervical fat pad. | ||
*'''U'''nusual br'''U'''ising. | |||
*'''S'''traiae on Skin. | *'''S'''traiae on Skin. | ||
*'''H'''ypertension + '''H'''yperglycemia. | *'''H'''ypertension + '''H'''yperglycemia. | ||
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*Crooke-hyaline change:<ref>{{Ref PCPBoD8|581}}</ref> | *Crooke-hyaline change:<ref>{{Ref PCPBoD8|581}}</ref> | ||
**ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous. | **ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous. | ||
<gallery> | |||
File:Crooke HE 40x.jpg | Crooke´s cell adenoma showing various Crooke cells with hyalinzed cytoplasms. (WC/marvin101) | |||
File:Crooke Cytokeratins.jpg | Ringlike perinuclear expression of cytokeratins in Crooke´s cell adenoma. (WC/marvin101) | |||
</gallery> | |||
==See also== | ==See also== | ||