Difference between revisions of "Oncogene"
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''' | An '''oncogene''' is a [[cancer]] gene, derived from a '''proto-oncogene'''. | ||
Examples | ==Examples== | ||
{| class="wikitable sortable" | |||
! Gene | |||
! Cancer | |||
|- | |||
| EGFR<ref name=omim131550>{{OMIM|131550}}</ref> | |||
| [[lung adenocarcinoma]], [[glioblastoma]],<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref> [[anaplastic astrocytoma]]<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref> | |||
|- | |||
| PDGFB<ref name=omim190040>{{OMIM|190040}}</ref> | |||
| [[dermatofibrosarcoma protuberans]] | |||
|- | |||
| BRAF<ref name=omim164757>{{OMIM|164757}}</ref> | |||
| [[papillary thyroid carcinoma tall cell variant]] | |||
|- | |||
| [[KRAS mutation|KRAS]]<ref name=omim190070>{{OMIM|190070}}</ref> | |||
| [[invasive ductal carcinoma of the pancreas]] | |||
|- | |||
| MYC<ref name=omim190080>{{OMIM|190080}}</ref> | |||
| [[Burkitt lymphoma]] | |||
|- | |||
| MET<ref name=omim164860>{{OMIM|164860}}</ref> | |||
| [[papillary renal cell carcinoma]] | |||
|- | |||
| ERBB2 (HER2)<ref name=omim164870>{{OMIM|164870}}</ref> | |||
| [[invasive breast carcinoma]] | |||
|- | |||
| CCND1 (BCL1)<ref name=omim168461>{{OMIM|168461}}</ref> | |||
| [[mantle cell lymphoma]] | |||
|- | |||
| EWSR1<ref name=omim133450>{{OMIM|133450}}</ref> | |||
| [[Ewing sarcoma]], [[clear cell sarcoma]], [[DSRCT]], [[extraskeletal myxoid chondrosarcoma|EMC]] | |||
|} | |||
==See also== | ==See also== | ||
*[[Tumour suppressor gene]]. | *[[Tumour suppressor gene]]. | ||
*[[Molecular pathology]]. | *[[Molecular pathology]]. | ||
==References== | |||
{{Reflist|2}} | |||
[[Category:Molecular pathology]] | [[Category:Molecular pathology]] | ||
Latest revision as of 12:07, 30 April 2014
An oncogene is a cancer gene, derived from a proto-oncogene.
Examples
| Gene | Cancer |
|---|---|
| EGFR[1] | lung adenocarcinoma, glioblastoma,[2] anaplastic astrocytoma[2] |
| PDGFB[3] | dermatofibrosarcoma protuberans |
| BRAF[4] | papillary thyroid carcinoma tall cell variant |
| KRAS[5] | invasive ductal carcinoma of the pancreas |
| MYC[6] | Burkitt lymphoma |
| MET[7] | papillary renal cell carcinoma |
| ERBB2 (HER2)[8] | invasive breast carcinoma |
| CCND1 (BCL1)[9] | mantle cell lymphoma |
| EWSR1[10] | Ewing sarcoma, clear cell sarcoma, DSRCT, EMC |
See also
References
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 131550
- ↑ 2.0 2.1 Lefkowitch, Jay H. (2006). Anatomic Pathology Board Review (1st ed.). Saunders. pp. 419 Q6. ISBN 978-1416025887.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190040
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164757
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190070
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 190080
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164860
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 164870
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 168461
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 133450