Difference between revisions of "Oncogene"

Latest revision as of 12:07, 30 April 2014

An oncogene is a cancer gene, derived from a proto-oncogene.

Gene	Cancer
EGFR^[1]	lung adenocarcinoma, glioblastoma,^[2] anaplastic astrocytoma^[2]
PDGFB^[3]	dermatofibrosarcoma protuberans
BRAF^[4]	papillary thyroid carcinoma tall cell variant
KRAS^[5]	invasive ductal carcinoma of the pancreas
MYC^[6]	Burkitt lymphoma
MET^[7]	papillary renal cell carcinoma
ERBB2 (HER2)^[8]	invasive breast carcinoma
CCND1 (BCL1)^[9]	mantle cell lymphoma
EWSR1^[10]	Ewing sarcoma, clear cell sarcoma, DSRCT, EMC

@@ Line 1: / Line 1: @@
-'''Oncogene''' is a cancer gene.
+An '''oncogene''' is a [[cancer]] gene, derived from a '''proto-oncogene'''.
+==Examples==
+{| class="wikitable sortable"
+! Gene
+! Cancer
+|-
+| EGFR<ref name=omim131550>{{OMIM|131550}}</ref>
+| [[lung adenocarcinoma]], [[glioblastoma]],<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref> [[anaplastic astrocytoma]]<ref name=Ref_APBR419>{{Ref APBR|419 Q6}}</ref>
+|-
+| PDGFB<ref name=omim190040>{{OMIM|190040}}</ref>
+| [[dermatofibrosarcoma protuberans]]
+|-
+| BRAF<ref name=omim164757>{{OMIM|164757}}</ref>
+| [[papillary thyroid carcinoma tall cell variant]]
+|-
+| [[KRAS mutation|KRAS]]<ref name=omim190070>{{OMIM|190070}}</ref>
+| [[invasive ductal carcinoma of the pancreas]]
+|-
+| MYC<ref name=omim190080>{{OMIM|190080}}</ref>
+| [[Burkitt lymphoma]]
+|-
+| MET<ref name=omim164860>{{OMIM|164860}}</ref>
+| [[papillary renal cell carcinoma]]
+|-
+| ERBB2 (HER2)<ref name=omim164870>{{OMIM|164870}}</ref>
+| [[invasive breast carcinoma]]
+|-
+| CCND1 (BCL1)<ref name=omim168461>{{OMIM|168461}}</ref>
+| [[mantle cell lymphoma]]
+|-
+| EWSR1<ref name=omim133450>{{OMIM|133450}}</ref>
+| [[Ewing sarcoma]], [[clear cell sarcoma]], [[DSRCT]], [[extraskeletal myxoid chondrosarcoma|EMC]]
+|}
 ==See also==
 *[[Tumour suppressor gene]].
 *[[Molecular pathology]].
+==References==
+{{Reflist|2}}
 [[Category:Molecular pathology]]