Difference between revisions of "Reactive follicular hyperplasia"

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#redirect [[Lymph_node_pathology#Reactive_follicular_hyperplasia]]
'''Reactive follicular hyperplasia''' is a benign [[Lymph node pathology|lymph node change]].
 
==General==
*Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
**In only approximately 10% can definitive cause be identified.<ref name=Ref_ILNP174>{{Ref_ILNP|174}}</ref>
 
==Microscopic==
Features:<ref name=Ref_ILNP179>{{Ref_ILNP|179}}</ref>
*Enlarged follicles, follicle size variation - '''key feature''' with:
**Large germinal centers (pale on H&E).
***Mitoses common.
***Variable lymphocyte morphology.
***Tingible-body macrophage (large, pale cells with junk in the cytoplasm).
***Germinal centers (GCs) have a crisp/sharp edge.
***Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker.
**Rim of small (inactive) lymphocytes.
 
DDx:
*[[Hodgkin lymphoma]] - with rare Reed-Sternberg cells.
*Non-Hodgkin [[lymphoma]]s.
**[[Follicular lymphoma]].
**T-cell/histiocyte-rich large B cell lymphoma.
**Others.
 
==IHC==
Screening panel:
*[[CD3]].
*[[CD5]].
*CD10.
*[[CD20]].
*CD30.
*CD15.
 
Others:
*BCL2 -ve.
**Germinal centers negative.
 
===Images===
<gallery>Image:Follicular lymphoma - control bcl2 -- low mag.jpg|BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. [[BCL2|BCL2 immunostain]].
</gallery>
 
==See also==
*[[Lymph node pathology]].
 
==References==
{{Reflist|1}}
 


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Haematopathology]]

Latest revision as of 15:25, 16 February 2021

Reactive follicular hyperplasia is a benign lymph node change.

General

  • Many causes - including: bacteria, viruses, chemicals, drugs, allergens.
    • In only approximately 10% can definitive cause be identified.[1]

Microscopic

Features:[2]

  • Enlarged follicles, follicle size variation - key feature with:
    • Large germinal centers (pale on H&E).
      • Mitoses common.
      • Variable lymphocyte morphology.
      • Tingible-body macrophage (large, pale cells with junk in the cytoplasm).
      • Germinal centers (GCs) have a crisp/sharp edge.
      • Normal dark/light variation of GCs; superficial aspect light, deeper aspect darker.
    • Rim of small (inactive) lymphocytes.

DDx:

IHC

Screening panel:

Others:

  • BCL2 -ve.
    • Germinal centers negative.

Images

  • BCL2 negative immunostaining in the germinal centers of reactive follicular hyperplasia. BCL2 immunostain.

See also

References

  1. ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 174. ISBN 978-0781775960.
  2. ↑ Ioachim, Harry L; Medeiros, L. Jeffrey (2008). Ioachim's Lymph Node Pathology (4th ed.). Lippincott Williams & Wilkins. pp. 179. ISBN 978-0781775960.
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