Difference between revisions of "Intramuscular myxoma"

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| Width      =  
| Width      =  
| Caption    = Intramuscular myxoma.  
| Caption    = Intramuscular myxoma.  
| Micro      =
| Micro      = myxoid stroma with bland stellate cells and/or bland spindle cells, intramuscular, usu. hypervascular and hypercellular
| Subtypes  =
| Subtypes  = hypercellular, hypervascular
| LMDDx      = [[myxoid lesions]]
| LMDDx      = [[myxoid lesions]]
| Stains    =
| Stains    =
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| Gross      =
| Gross      =
| Grossing  =
| Grossing  =
| Site      = [[Soft tissue]]
| Site      = [[soft tissue]]
| Assdx      =
| Assdx      =
| Syndromes  =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Signs      =
| Symptoms  =
| Symptoms  =
| Prevalence =
| Prevalence = rare
| Bloodwork  =
| Bloodwork  =
| Rads      =
| Rads      =
| Endoscopy  =
| Endoscopy  =
| Prognosis  =
| Prognosis  = benign, rarely recur
| Other      =
| Other      =
| ClinDDx    =
| ClinDDx    =
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==General==
==General==
*Rare.<ref name=pmid15663047>{{Cite journal  | last1 = Charron | first1 = P. | last2 = Smith | first2 = J. | title = Intramuscular myxomas: a clinicopathologic study with emphasis on surgical management. | journal = Am Surg | volume = 70 | issue = 12 | pages = 1073-7 | month = Dec | year = 2004 | doi =  | PMID = 15663047 }}</ref>
*Rare.<ref name=pmid15663047>{{Cite journal  | last1 = Charron | first1 = P. | last2 = Smith | first2 = J. | title = Intramuscular myxomas: a clinicopathologic study with emphasis on surgical management. | journal = Am Surg | volume = 70 | issue = 12 | pages = 1073-7 | month = Dec | year = 2004 | doi =  | PMID = 15663047 }}</ref>
*Usually do not recur.<ref name=pmid12360026>{{Cite journal  | last1 = Silver | first1 = WP. | last2 = Harrelson | first2 = JM. | last3 = Scully | first3 = SP. | title = Intramuscular myxoma: a clinicopathologic study of 17 patients. | journal = Clin Orthop Relat Res | volume =  | issue = 403 | pages = 191-7 | month = Oct | year = 2002 | doi =  | PMID = 12360026 }}</ref>
*Present as a mass.<ref name=pmid12360026/>
==Gross==
*Usually thigh muscles.<ref name=pmid12360026/>


==Microscopic==
==Microscopic==
Features:<ref name=pmid15663047/>
Features:<ref name=pmid15663047/><ref name=pmid9777984/>
*Myxoid stroma.
*Myxoid stroma - '''key feature'''
**Paucicellular.
*Bland stellate or spindle cells.  
**Scant vascularity.  
**Typically paucicellular. †
*Contained within skeletal muscle.
**Usually with scant vascularity. ‡
*Contained within skeletal muscle - '''essential'''.
 
Note:
*† A hypercellular variant exists.
*‡ A hypervascular variant exists.


DDx:
DDx:<ref name=pmid9777984>{{Cite journal  | last1 = Nielsen | first1 = GP. | last2 = O'Connell | first2 = JX. | last3 = Rosenberg | first3 = AE. | title = Intramuscular myxoma: a clinicopathologic study of 51 cases with emphasis on hypercellular and hypervascular variants. | journal = Am J Surg Pathol | volume = 22 | issue = 10 | pages = 1222-7 | month = Oct | year = 1998 | doi =  | PMID = 9777984 }}</ref>
*[[Low-grade fibromyxoid sarcoma]].<ref name=pmid23685711>{{Cite journal  | last1 = Yamashita | first1 = H. | last2 = Endo | first2 = K. | last3 = Takeda | first3 = C. | last4 = Teshima | first4 = R. | last5 = Osaki | first5 = M. | last6 = Yoshida | first6 = H. | title = Intramuscular myxoma of the buttock mimicking low-grade fibromyxoid sarcoma: diagnostic usefulness of MUC4 expression. | journal = Skeletal Radiol | volume =  | issue =  | pages =  | month = May | year = 2013 | doi = 10.1007/s00256-013-1641-4 | PMID = 23685711 }}</ref>
*[[Low-grade fibromyxoid sarcoma]].<ref name=pmid23685711>{{Cite journal  | last1 = Yamashita | first1 = H. | last2 = Endo | first2 = K. | last3 = Takeda | first3 = C. | last4 = Teshima | first4 = R. | last5 = Osaki | first5 = M. | last6 = Yoshida | first6 = H. | title = Intramuscular myxoma of the buttock mimicking low-grade fibromyxoid sarcoma: diagnostic usefulness of MUC4 expression. | journal = Skeletal Radiol | volume =  | issue =  | pages =  | month = May | year = 2013 | doi = 10.1007/s00256-013-1641-4 | PMID = 23685711 }}</ref>
*[[Myxoid liposarcoma]].
*[[Myxofibrosarcoma]]
*[[Juxta-articular myxoma]].


===Images===
===Images===
<gallery>
<gallery>
Image: IntramuscularMyxoma.JPG | Intramuscular myxoma. (WC)
Image: Intramuscular myxoma - low mag.jpg | Low mag. (WC/Nephron)
Image: Intramuscular myxoma - intermed mag.jpg | Intermed. mag. (WC/Nephron)
Image: Intramuscular myxoma - extra1 - intermed mag.jpg | Intermed. mag. (WC/Nephron)
Image: Intramuscular myxoma - extra2 - intermed mag.jpg | Intermed. mag. (WC/Nephron)
Image: Intramuscular myxoma - high mag.jpg | High mag. (WC/Nephron)
Image: Intramuscular myxoma - very high mag.jpg | Very high mag. (WC/Nephron)
</gallery>
</gallery>


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==References==
==References==
{{Reflist|1}}
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Soft tissue pathology]]
[[Category:Soft tissue lesions]]

Latest revision as of 20:54, 5 July 2013

Intramuscular myxoma is an uncommon benign intramuscular myxoid lesion.

Intramuscular myxoma
Diagnosis in short

Intramuscular myxoma.
LM myxoid stroma with bland stellate cells and/or bland spindle cells, intramuscular, usu. hypervascular and hypercellular
Subtypes hypercellular, hypervascular
LM DDx myxoid lesions
Site soft tissue
Prevalence rare
Prognosis benign, rarely recur

General

  • Rare.[1]
  • Usually do not recur.[2]
  • Present as a mass.[2]

Gross

  • Usually thigh muscles.[2]

Microscopic

Features:[1][3]

  • Myxoid stroma - key feature
  • Bland stellate or spindle cells.
    • Typically paucicellular. †
    • Usually with scant vascularity. ‡
  • Contained within skeletal muscle - essential.

Note:

  • † A hypercellular variant exists.
  • ‡ A hypervascular variant exists.

DDx:[3]

Images

  • Low mag. (WC/Nephron)

  • Intermed. mag. (WC/Nephron)

  • Intermed. mag. (WC/Nephron)

  • Intermed. mag. (WC/Nephron)

  • High mag. (WC/Nephron)

  • Very high mag. (WC/Nephron)

See also

References

  1. ↑ 1.0 1.1 Charron, P.; Smith, J. (Dec 2004). "Intramuscular myxomas: a clinicopathologic study with emphasis on surgical management.". Am Surg 70 (12): 1073-7. PMID 15663047.
  2. ↑ 2.0 2.1 2.2 Silver, WP.; Harrelson, JM.; Scully, SP. (Oct 2002). "Intramuscular myxoma: a clinicopathologic study of 17 patients.". Clin Orthop Relat Res (403): 191-7. PMID 12360026.
  3. ↑ 3.0 3.1 Nielsen, GP.; O'Connell, JX.; Rosenberg, AE. (Oct 1998). "Intramuscular myxoma: a clinicopathologic study of 51 cases with emphasis on hypercellular and hypervascular variants.". Am J Surg Pathol 22 (10): 1222-7. PMID 9777984.
  4. ↑ Yamashita, H.; Endo, K.; Takeda, C.; Teshima, R.; Osaki, M.; Yoshida, H. (May 2013). "Intramuscular myxoma of the buttock mimicking low-grade fibromyxoid sarcoma: diagnostic usefulness of MUC4 expression.". Skeletal Radiol. doi:10.1007/s00256-013-1641-4. PMID 23685711.
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