Difference between revisions of "NUT carcinoma"
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'''NUT midline carcinoma''' is a super rare tumour. | '''NUT midline carcinoma''', abbreviated '''NMC''', is a super rare tumour of the [[head and neck pathology|head and neck]]. | ||
==General== | ==General== | ||
| Line 8: | Line 8: | ||
Clinical: | Clinical: | ||
*Usually midline - as the name of the tumour suggests. | *Usually midline - as the name of the tumour suggests. | ||
**Case report of a NMC in the parotid gland.<ref name=pmid19561446>{{Cite journal | last1 = den Bakker | first1 = MA. | last2 = Beverloo | first2 = BH. | last3 = van den Heuvel-Eibrink | first3 = MM. | last4 = Meeuwis | first4 = CA. | last5 = Tan | first5 = LM. | last6 = Johnson | first6 = LA. | last7 = French | first7 = CA. | last8 = van Leenders | first8 = GJ. | title = NUT midline carcinoma of the parotid gland with mesenchymal differentiation. | journal = Am J Surg Pathol | volume = 33 | issue = 8 | pages = 1253-8 | month = Aug | year = 2009 | doi = 10.1097/PAS.0b013e3181abe120 | PMID = 19561446 }} | |||
</ref> | |||
*[[Head and neck pathology|Head, neck]] and [[mediastinum]].<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | *[[Head and neck pathology|Head, neck]] and [[mediastinum]].<ref name=pmid18552174>{{Cite journal | last1 = French | first1 = CA. | title = Demystified molecular pathology of NUT midline carcinomas. | journal = J Clin Pathol | volume = 63 | issue = 6 | pages = 492-6 | month = Jun | year = 2010 | doi = 10.1136/jcp.2007.052902 | PMID = 18552174 }}</ref> | ||
* | *Very poor prognosis.<ref name=pmid19561446/> | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 05:37, 17 November 2011
NUT midline carcinoma, abbreviated NMC, is a super rare tumour of the head and neck.
General
- Not specific to any tissue type or organ.[1]
- Defined by mutation in NUT gene.
- NUT = Nuclear protein in testis.[2]
Clinical:
- Usually midline - as the name of the tumour suggests.
- Case report of a NMC in the parotid gland.[3]
- Head, neck and mediastinum.[4]
- Very poor prognosis.[3]
Microscopic
- Poorly differentiated carcinoma.
- Cohesive malignant cells.
- Islands of well-differentiated squamous epithelium - key feature.
DDx:
- Carcinoma ex pleomorphic adenoma.
- Poorly differentiated carcinoma.
Molecular
- Rearrangement of the NUT gene.[1]
See also
References
- ↑ 1.0 1.1 1.2 French, CA. (Nov 2010). "NUT midline carcinoma.". Cancer Genet Cytogenet 203 (1): 16-20. doi:10.1016/j.cancergencyto.2010.06.007. PMID 20951314.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608963
- ↑ 3.0 3.1 den Bakker, MA.; Beverloo, BH.; van den Heuvel-Eibrink, MM.; Meeuwis, CA.; Tan, LM.; Johnson, LA.; French, CA.; van Leenders, GJ. (Aug 2009). "NUT midline carcinoma of the parotid gland with mesenchymal differentiation.". Am J Surg Pathol 33 (8): 1253-8. doi:10.1097/PAS.0b013e3181abe120. PMID 19561446.
- ↑ 4.0 4.1 4.2 French, CA. (Jun 2010). "Demystified molecular pathology of NUT midline carcinomas.". J Clin Pathol 63 (6): 492-6. doi:10.1136/jcp.2007.052902. PMID 18552174.
- ↑ Online 'Mendelian Inheritance in Man' (OMIM) 608749