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Difference between revisions of "Vasculitides"
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→Small vessel leukocytoclastic vasculitis
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Clinical: | Clinical: | ||
*Palpable purpura, usu. lower extremity. | *Palpable purpura, usu. lower extremity. | ||
===Microscopic=== | ===Microscopic=== | ||
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*#*Fragmentation of neutrophils (leukocytoclasia). | *#*Fragmentation of neutrophils (leukocytoclasia). | ||
*#Vessel damage: fibrin deposition (bright pink acellular stuff). | *#Vessel damage: fibrin deposition (bright pink acellular stuff). | ||
Has a very broad DDx:<ref name=pmid18948765/> | |||
#Infectious: | |||
#*Bacterial. | |||
#*Viral. | |||
#*Fungal. | |||
#Vasculitic disorders: | |||
#*ANCA mediated vasculitides: | |||
#**[[Wegener granulomatosis]]. | |||
#**[[Churg-Strauss syndrome]]. | |||
#*Henoch–Schönlein purpura. | |||
#*Urticarial vasculitis. | |||
#Other: | |||
#*Connective tissue disease. | |||
#*Cryoglobulinemia - may be due to [[multiple myeloma]], [[hepatitis C]]; have intravascular thrombi. | |||
#*Paraneoplastic. | |||
#*Drugs. | |||
Image: | Image: | ||
*[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | *[http://www.ancavasculitis.com/biopsy.php LCA (ancavasculitis.com)]. | ||
===Stains=== | |||
*PAS - look for fungus. | |||
==Giant cell arteritis== | ==Giant cell arteritis== | ||