Difference between revisions of "Neuropathology tumours"

Neuropathology tumours (view source)

322 bytes added , 14:30, 31 May 2010

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 *Highly cellular lesion composed of:
 **Cells resembling ''fried eggs'' (oligodendrocytes) with:
+***Round nucleus - '''key feature'''.
 ***Distinct cell borders.
 ***Moderate-to-marked nuclear atypia.
-***Clear cytoplasm.
+***Clear cytoplasm - useful feature (if present).
+****Some oligodendrogliomas have eosinophilic cytoplasm with focal perinuclear clearing.
 **Acutely branched capillary sized vessels - "chicken-wire" like appearance.
 ***Abundant, delicate appearing; may vaguely resemble a paraganglioma at low power.
-*Calcifications.<ref>URL: [http://www.emedicine.com/radio/topic481.htm http://www.emedicine.com/radio/topic481.htm].</ref> - important feature.
+*Calcifications - important feature.<ref>URL: [http://www.emedicine.com/radio/topic481.htm http://www.emedicine.com/radio/topic481.htm].</ref>
 Images:
 *[http://commons.wikimedia.org/wiki/File:Oligodendroglioma1_high_mag.jpg Oligodendroglioma high mag. (WC)].
 *[http://commons.wikimedia.org/wiki/File:Oligodendroglioma1_low_mag.jpg Oligodendroglioma low mag. (WC)].
+Notes:
+*Few neural tumours have round nuclei - DDx:
+**Oligodendroglioma.
+**Lymphoma.
+**Clear cell variant of ependymoma.
+**Germ cell tumour (dysgerminoma/seminoma).
 ===IHC===