Clear cell papillary renal cell tumour: Difference between revisions
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| Caption = Clear cell papillary renal cell tumour. [[H&E stain]]. | | Caption = Clear cell papillary renal cell tumour. [[H&E stain]]. | ||
| Synonyms = previously known as ''clear cell tubulopapillary renal cell carcinoma'' and ''clear cell papillary renal cell carcinoma'' | | Synonyms = previously known as ''clear cell tubulopapillary renal cell carcinoma'' and ''clear cell papillary renal cell carcinoma'' | ||
| Micro = low ([[ISUP nucleolar grade|ISUP nucleolar]]) grade apical nuclei, clear cells, pseudopapillae, cystic and/or tubular architectures | | Micro = low ([[ISUP nucleolar grade|ISUP nucleolar]]) grade apical nuclei (reverse polarized), clear cells, pseudopapillae, cystic and/or tubular architectures | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], [[Xp11.2 translocation carcinoma]] | | LMDDx = [[clear cell renal cell carcinoma]], [[papillary renal cell carcinoma]], [[Xp11.2 translocation carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = CK7 +ve, | | IHC = CK7 +ve, GATA-3 +ve, MA903 +ve, CD10 -ve, AMACR -ve, TFE3 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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It was previously known as '''clear cell papillary renal cell carcinoma''', abbreviated '''CCPRCC''' | It was previously known as '''clear cell papillary renal cell carcinoma''', abbreviated '''CCPRCC''' | ||
It | It was also previously known as '''clear cell tubulopapillary renal cell carcinoma''',<ref name=pmid21602815>{{Cite journal | last1 = Rohan | first1 = SM. | last2 = Xiao | first2 = Y. | last3 = Liang | first3 = Y. | last4 = Dudas | first4 = ME. | last5 = Al-Ahmadie | first5 = HA. | last6 = Fine | first6 = SW. | last7 = Gopalan | first7 = A. | last8 = Reuter | first8 = VE. | last9 = Rosenblum | first9 = MK. | title = Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. | journal = Mod Pathol | volume = 24 | issue = 9 | pages = 1207-20 | month = Sep | year = 2011 | doi = 10.1038/modpathol.2011.80 | PMID = 21602815 }}</ref> abbreviated '''CCTPRCC'''. | ||
==General== | ==General== | ||
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<pre> | <pre> | ||
A. Left Kidney Mass, Radical Nephrectomy: | A. Left Kidney Mass, Radical Nephrectomy: | ||
- CLEAR CELL PAPILLARY RENAL CELL TUMOUR, nucleolar grade 1 of 4, see comment. | |||
-- Margins clear. | -- Margins clear. | ||
-- Please see synoptic report. | -- Please see synoptic report. | ||
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NEGATIVE: CD10, AMACR. | NEGATIVE: CD10, AMACR. | ||
The findings are in keeping with clear cell papillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma". | The findings are in keeping with clear cell papillary renal cell tumour. These tumours were previously called "clear cell papillary renal cell carcinoma".[1] | ||
These tumours have a highly favourable clinical behaviour.[ | These tumours have a highly favourable clinical behaviour.[2,3] | ||
1. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513 | 1. Pathologica. 2022 Feb;115(1):8-22. doi: 10.32074/1591-951X-818. https://pmc.ncbi.nlm.nih.gov/articles/PMC10342217/ | ||
2. Am J Surg Pathol. 2015 Dec;39(12):1621-34. DOI: 10.1097/PAS.0000000000000513 | |||
3. Pathology. 2020 Nov 19;S0031-3025(20)30957-0. DOI: 10.1016/j.pathol.2020.10.002 | |||
</pre> | </pre> | ||
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Diagnosing the this entity on biopsy should be done with caution as: | Diagnosing the this entity on biopsy should be done with caution as: | ||
*Overlaps are described between ''clear cell renal cell carcinoma'' and ''clear cell papillary renal cell tumour''.<ref name=pmid26752401>{{cite journal |vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG |title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution |journal=Am J Surg Pathol |volume=40 |issue=2 |pages=141–54 |date=February 2016 |pmid=26752401 |doi=10.1097/PAS.0000000000000583 |url=}}</ref> | *Overlaps are described between ''clear cell renal cell carcinoma'' and ''clear cell papillary renal cell tumour''.<ref name=pmid26752401>{{cite journal |vauthors=Dhakal HP, McKenney JK, Khor LY, Reynolds JP, Magi-Galluzzi C, Przybycin CG |title=Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution |journal=Am J Surg Pathol |volume=40 |issue=2 |pages=141–54 |date=February 2016 |pmid=26752401 |doi=10.1097/PAS.0000000000000583 |url=}}</ref> | ||
*''Clear cell papillary renal cell tumour'' may also be seen in conjunction with (other) renal cell | *''Clear cell papillary renal cell tumour'' may also be seen in conjunction with (other) renal cell carcinoma(s).<ref name=pmid26857533>{{cite journal |authors=Shao T, Yousef P, Shipilova I, Saleeb R, Lee JY, Krizova A |title=Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature |journal=Pathol Res Pract |volume=212 |issue=3 |pages=229–33 |date=March 2016 |pmid=26857533 |doi=10.1016/j.prp.2015.12.007 |url=}}</ref> | ||
==See also== | ==See also== | ||