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Neuroendocrine markers (view source)
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'''Neuroendocrine markers''' are [[immunostains]] that suggest neuroendocrine differentiation. | '''Neuroendocrine markers''' are [[immunostains]] that suggest neuroendocrine differentiation. | ||
==Common markers== | |||
*[[Chromogranin A]]. | |||
**Considered the most specific neuroendocrine stain.<ref name=pmid20182342>{{Cite journal | last1 = McCluggage | first1 = WG. | last2 = Kennedy | first2 = K. | last3 = Busam | first3 = KJ. | title = An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63. | journal = Am J Surg Pathol | volume = 34 | issue = 4 | pages = 525-32 | month = Apr | year = 2010 | doi = 10.1097/PAS.0b013e3181d1d457 | PMID = 20182342 }}</ref> | |||
*Synaptophysin +ve. | |||
*[[CD56]]. | |||
**Less specific than chromogranin A and synaptophysin. | |||
===Less common markers=== | |||
*INSM1 (Insulinoma-associated Protein 1).<ref>{{cite journal |authors=Sakakibara R, Kobayashi M, Takahashi N, Inamura K, Ninomiya H, Wakejima R, Kitazono S, Yanagitani N, Horiike A, Ichinose J, Matsuura Y, Nakao M, Mun M, Nishio M, Okumura S, Motoi N, Ito T, Miyazaki Y, Inase N, Ishikawa Y |title=Insulinoma-associated Protein 1 (INSM1) Is a Better Marker for the Diagnosis and Prognosis Estimation of Small Cell Lung Carcinoma Than Neuroendocrine Phenotype Markers Such as Chromogranin A, Synaptophysin, and CD56 |journal=Am J Surg Pathol |volume=44 |issue=6 |pages=757–764 |date=June 2020 |pmid=32118626 |doi=10.1097/PAS.0000000000001444 |url=}}</ref> | |||
*NSE. | |||
*CD57. | |||
*PGP9.5. | |||
==See also== | ==See also== | ||
*[[Immunohistochemistry]]. | *[[Immunohistochemistry]]. | ||
*[[Neuroendocrine tumours]]. | *[[Neuroendocrine tumours]]. | ||
==References== | |||
{{Reflist|1}} | |||
[[Category:Immunohistochemistry]] | [[Category:Immunohistochemistry]] | ||