Medial calcific sclerosis: Difference between revisions

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#redirect [[Vascular_disease#Medial_calcific_sclerosis]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Medial calcific sclerosis -- intermed mag.jpg
| Width      =
| Caption    = Medial calcific sclerosis. [[H&E stain]].
| Synonyms  = Moenckeberg medial calcific sclerosis, calcific medial sclerosis of Monckeberg, Mönckeberg's arteriosclerosis (also written ''Monckeberg's arteriosclerosis'')
| Micro      = calcifications of the tunica media
| Subtypes  =
| LMDDx      = [[atherosclerosis]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Staging    =
| Site      = [[blood vessels]] - arteries
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = good
| Other      =
| ClinDDx    =
| Tx        = (nothing)
}}
'''Medial calcific sclerosis''' is a type of arteriosclerosis that has no significant clinical impact.


It is also known as '''Moenckeberg medial calcific sclerosis''', '''calcific medial sclerosis of Monckeberg''', and '''Mönckeberg's arteriosclerosis''' (also written '''Monckeberg's arteriosclerosis''').
==General==
*Usually of no clinical consequence.
*May impact vascular assessments using ultrasound.<ref>{{cite journal |authors=Suludere MA, Danesh SK, Killeen AL, Crisologo PA, Malone M, Siah MC, Lavery LA |title=Mönckeberg's Medial Calcific Sclerosis Makes Traditional Arterial Doppler's Unreliable in High-Risk Patients with Diabetes |journal=Int J Low Extrem Wounds |volume= |issue= |pages=15347346231191588 |date=July 2023 |pmid=37525549 |doi=10.1177/15347346231191588 |url=}}</ref>
==Microscopic==
Features:<ref name=Ref_Klatt7>{{Ref Klatt|7}}</ref>
*Medial calcification (purple irregular stuff on [[H&E stain|H&E]] -- calcium phosphate).
Note:
*Lumen unaffected.
*It has been suggested that it usually involves the ''internal elastic lamina''.<ref>{{cite journal |authors=Micheletti RG, Fishbein GA, Currier JS, Fishbein MC |title=Mönckeberg sclerosis revisited: a clarification of the histologic definition of Mönckeberg sclerosis |journal=Arch Pathol Lab Med |volume=132 |issue=1 |pages=43–7 |date=January 2008 |pmid=18181672 |doi=10.5858/2008-132-43-MSRACO |url=}}</ref>
DDx:<ref>{{cite journal |authors=Dos Santos VP, Pozzan G, Castelli V, Caffaro RA |title=Arteriosclerosis, atherosclerosis, arteriolosclerosis, and Monckeberg medial calcific sclerosis: what is the difference? |journal=J Vasc Bras |volume=20 |issue= |pages=e20200211 |date=2021 |pmid=34290756 |pmc=8276643 |doi=10.1590/1677-5449.200211 |url=}}</ref>
*[[Atherosclerosis]] (severe) - intimal hyperplasia with stenosis, calcifications typically in tunica intima.
===Images===
<gallery>
Image: Medial calcific sclerosis -- low mag.jpg | MCS - low mag. (WC)
Image: Medial calcific sclerosis -- intermed mag.jpg | MCS - intermed. mag. (WC)
Image: Medial calcific sclerosis -- high mag.jpg | MCS - high mag. (WC)
Image: Medial calcific sclerosis - alt -- intermed mag.jpg | MCS - intermed. mag. (WC)
Image: Medial calcific sclerosis - alt -- high mag.jpg | MCS - high mag. (WC)
</gallery>
<gallery>
Image:Calcificatio_atherosclerotica.jpg | MCS. (WC)
</gallery>
==Sign out==
<pre>
RIGHT LEG, BELOW KNEE AMPUTATION:
- MINIMAL-TO-MILD LARGE VESSEL ATHEROSCLEROSIS, SEE COMMENT.
- MEDIAL CALCIFIC SCLEROSIS.
- SKIN WITH DERMAL FIBROSIS.
COMMENT:
The sections may not be representative of disease in the distal vascular bed.
</pre>
==See also==
*[[Vascular disease]].
==References==
{{Reflist|1}}
[[Category:Cardiovascular pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]
Retrieved from "https://librepathology.org/wiki/Medial_calcific_sclerosis"