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Difference between revisions of "Talk:P16"
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p16 staining in non-oropharyngeal sites is nonspecific in a diagnostic context. | p16 staining in non-oropharyngeal sites is nonspecific in a diagnostic context. | ||
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== More on p16 in oral sites== | |||
*p16 in oral sites usually not HPV driven. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836441/ | |||
== Cutaneous SCC == | |||
*p16 positive in ~ 1/3 cases - https://pubmed.ncbi.nlm.nih.gov/28663082/ | |||
== p16 UCC == | |||
https://pubmed.ncbi.nlm.nih.gov/20164052/ | |||
== p16 +ve H&N SqCC vs Lung Primary == | |||
<pre> | <pre> | ||
Lung primaries are commonly positive for p16[1]; thus, p16 CANNOT be used to reliably differentiate between p16 positive head and neck cancers and lung cancer. | |||
1. Br J Cancer. 2000 Jan;82(2):374-80. doi: 10.1054/bjoc.1999.0929. https://pubmed.ncbi.nlm.nih.gov/10646891/ | |||
https://doi.org/10.1054/bjoc.1999.0929 | |||
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== Penile ca == | |||
https://doi.org/10.1158/1055-9965.EPI-18-0322 | |||
Meta-analysis showed p16 IHC criteria variable | |||
WHO 2022 ( https://pubmed.ncbi.nlm.nih.gov/36221864/ ): block type positivity (not further specified) = positive | |||