Difference between revisions of "Papillary renal neoplasm with reverse polarity"

Jump to navigation Jump to search
+another case
(+another case)
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{ Infobox diagnosis
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Name      = {{PAGENAME}}
| Image      = Papillary renal neoplasm with reverse polarity - alt -- high mag.jpg
| Image      = Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg  
| Width      =
| Width      =
| Caption    = Papillary renal neoplasm with reverse polarity. [[H&E stain]].
| Caption    = Papillary renal neoplasm with reverse polarity. [[H&E stain]].
Line 38: Line 38:
*Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref>
*Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref>


==Micro==
==Microscopic==
Features:<ref name=pmid31135486/>
Features:<ref name=pmid31135486/>
*Branching papillae with:
*Branching papillae with:
Line 53: Line 53:


===Images===
===Images===
====Case 1====
<gallery>
Image: Papillary renal neoplasm with reverse polarity - 2 -- very low mag.jpg | PRNRP - very low mag.
Image: Papillary renal neoplasm with reverse polarity - 2 -- low mag.jpg | PRNRP - low mag.
Image: Papillary renal neoplasm with reverse polarity - 2 -- intermed mag.jpg | PRNRP - intermed. mag.
Image: Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg | PRNRP - high mag.
Image: Papillary renal neoplasm with reverse polarity - 2 -- very high mag.jpg | PRNRP - very high mag.
</gallery>
====Case 2====
<gallery>
<gallery>
Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg | PRNRP - very low mag.
Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg | PRNRP - very low mag.
Line 64: Line 74:
==IHC==
==IHC==
Features:<ref name=pmid31135486/>
Features:<ref name=pmid31135486/>
*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>) - '''key stain'''.
**Negative in other papillary RCCs.<ref name=pmid37797754/>
*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>).
*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>).
*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>).
*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>).
*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>).
**Negative in other papillary RCCs.<ref name=pmid37797754/>
*Vimentin -ve (all cases).
*Vimentin -ve (all cases).
*CD117 -ve.
*CD117 -ve.
Line 73: Line 83:
*EMA +ve.
*EMA +ve.
*L1CAM +ve.
*L1CAM +ve.
*PAX8 +ve.
*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).
*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>).
*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).
*RCC -ve (1 of 43 cases<ref name=pmid37797754/>).


===Stains that help differentiate between papillary RCC and PRNRP adapted from Kim ''et al.''<ref name=pmid37797754/>===
===Differentiating between papillary RCC and PRNRP===
Adapted from Kim ''et al.'':<ref name=pmid37797754/>
{| class="wikitable sortable"  
{| class="wikitable sortable"  
!Diagnosis  
!Diagnosis  
48,976

edits

Navigation menu