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Difference between revisions of "Papillary renal neoplasm with reverse polarity"
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Papillary renal neoplasm with reverse polarity (view source)
Revision as of 20:08, 14 March 2025
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Papillary renal neoplasm with reverse polarity - | | Image = Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = Papillary renal neoplasm with reverse polarity. [[H&E stain]]. | | Caption = Papillary renal neoplasm with reverse polarity. [[H&E stain]]. | ||
| Line 38: | Line 38: | ||
*Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | *Early data suggests an indolent behaviour.<ref name=pmid31135486>{{cite journal |authors=Al-Obaidy KI, Eble JN, Cheng L, Williamson SR, Sakr WA, Gupta N, Idrees MT, Grignon DJ |title=Papillary Renal Neoplasm With Reverse Polarity: A Morphologic, Immunohistochemical, and Molecular Study |journal=Am J Surg Pathol |volume=43 |issue=8 |pages=1099–1111 |date=August 2019 |pmid=31135486 |doi=10.1097/PAS.0000000000001288 |url=}}</ref> | ||
== | ==Microscopic== | ||
Features:<ref name=pmid31135486/> | Features:<ref name=pmid31135486/> | ||
*Branching papillae with: | *Branching papillae with: | ||
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===Images=== | ===Images=== | ||
====Case 1==== | |||
<gallery> | |||
Image: Papillary renal neoplasm with reverse polarity - 2 -- very low mag.jpg | PRNRP - very low mag. | |||
Image: Papillary renal neoplasm with reverse polarity - 2 -- low mag.jpg | PRNRP - low mag. | |||
Image: Papillary renal neoplasm with reverse polarity - 2 -- intermed mag.jpg | PRNRP - intermed. mag. | |||
Image: Papillary renal neoplasm with reverse polarity - 2 -- high mag.jpg | PRNRP - high mag. | |||
Image: Papillary renal neoplasm with reverse polarity - 2 -- very high mag.jpg | PRNRP - very high mag. | |||
</gallery> | |||
====Case 2==== | |||
<gallery> | <gallery> | ||
Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg | PRNRP - very low mag. | Image: Papillary renal neoplasm with reverse polarity -- very low mag.jpg | PRNRP - very low mag. | ||
| Line 64: | Line 74: | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid31135486/> | Features:<ref name=pmid31135486/> | ||
*GATA3 +ve (43 of 43 cases<ref name=pmid37797754/>) - '''key stain'''. | |||
**Negative in other papillary RCCs.<ref name=pmid37797754/> | |||
*CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>). | *CK7 +ve (88% +ve, 37 of 42 cases<ref name=pmid37797754/>). | ||
*CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>). | *CD10 +ve/-ve (50% +ve, 21 of 42 cases<ref name=pmid37797754/>). | ||
*Vimentin -ve (all cases). | *Vimentin -ve (all cases). | ||
*CD117 -ve. | *CD117 -ve. | ||
| Line 73: | Line 83: | ||
*EMA +ve. | *EMA +ve. | ||
*L1CAM +ve. | *L1CAM +ve. | ||
*PAX8 +ve. | |||
*AMACR -ve (4 of 43 cases<ref name=pmid37797754/>). | *AMACR -ve (4 of 43 cases<ref name=pmid37797754/>). | ||
*RCC -ve (1 of 43 cases<ref name=pmid37797754/>). | *RCC -ve (1 of 43 cases<ref name=pmid37797754/>). | ||
=== | ===Differentiating between papillary RCC and PRNRP=== | ||
Adapted from Kim ''et al.'':<ref name=pmid37797754/> | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
!Diagnosis | !Diagnosis | ||