49,012
edits
Difference between revisions of "Endometriosis"
Jump to navigation
Jump to search
no edit summary
| (6 intermediate revisions by the same user not shown) | |||
| Line 8: | Line 8: | ||
| LMDDx = [[adenocarcinoma]], [[endosalpingiosis]] | | LMDDx = [[adenocarcinoma]], [[endosalpingiosis]] | ||
| Stains = | | Stains = | ||
| IHC = [[CD10]] +ve (stroma) | | IHC = CK7 +ve, ER +ve, [[CD10]] +ve (stroma), CK20 -ve, CDX2 -ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 21: | Line 21: | ||
| Symptoms = +/-pelvic pain, +/-deep dyspareunia | | Symptoms = +/-pelvic pain, +/-deep dyspareunia | ||
| Prevalence = common | | Prevalence = common | ||
| Bloodwork = CA-125 mildly elevated | | Bloodwork = [[CA-125]] mildly elevated | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Line 74: | Line 74: | ||
*Endometriosis can appear almost any where. | *Endometriosis can appear almost any where. | ||
**A well-reported uncommon location is the abdominal wall post-caesarian section.<ref name=pmid22381104>{{Cite journal | last1 = Ozel | first1 = L. | last2 = Sagiroglu | first2 = J. | last3 = Unal | first3 = A. | last4 = Unal | first4 = E. | last5 = Gunes | first5 = P. | last6 = Baskent | first6 = E. | last7 = Aka | first7 = N. | last8 = Titiz | first8 = MI. | last9 = Tufekci | first9 = EC. | title = Abdominal wall endometriosis in the cesarean section surgical scar: a potential diagnostic pitfall. | journal = J Obstet Gynaecol Res | volume = 38 | issue = 3 | pages = 526-30 | month = Mar | year = 2012 | doi = 10.1111/j.1447-0756.2011.01739.x | PMID = 22381104 }}</ref> | **A well-reported uncommon location is the abdominal wall post-caesarian section.<ref name=pmid22381104>{{Cite journal | last1 = Ozel | first1 = L. | last2 = Sagiroglu | first2 = J. | last3 = Unal | first3 = A. | last4 = Unal | first4 = E. | last5 = Gunes | first5 = P. | last6 = Baskent | first6 = E. | last7 = Aka | first7 = N. | last8 = Titiz | first8 = MI. | last9 = Tufekci | first9 = EC. | title = Abdominal wall endometriosis in the cesarean section surgical scar: a potential diagnostic pitfall. | journal = J Obstet Gynaecol Res | volume = 38 | issue = 3 | pages = 526-30 | month = Mar | year = 2012 | doi = 10.1111/j.1447-0756.2011.01739.x | PMID = 22381104 }}</ref> | ||
*Intraluminal endometriosis in the Fallopian tube - is relatively common,<ref>{{cite journal |authors=Hill CJ, Fakhreldin M, Maclean A, Dobson L, Nancarrow L, Bradfield A, Choi F, Daley D, Tempest N, Hapangama DK |title=Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications |journal=J Clin Med |volume=9 |issue=6 |pages= |date=June 2020 |pmid=32570847 |pmc=7355596 |doi=10.3390/jcm9061905 |url=}}</ref> it may be less obvious to the surgeon. | |||
===Images=== | |||
<gallery> | |||
Image: Endometriosis,_abdominal_wall.jpg |Endometriosis in C-section scar at cut-up. (Ed Uthman/WC) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
| Line 89: | Line 95: | ||
DDx: | DDx: | ||
*[[Adenocarcinoma]]. | *[[Adenocarcinoma]] - especially colorectal adenocarcinoma. | ||
*[[Endosalpingiosis]] - does not have stromal component. | *[[Endosalpingiosis]] - does not have stromal component. | ||
**In the GI tract, it classically expands the muscularis propria. | **In the GI tract, it classically expands the muscularis propria. | ||
| Line 109: | Line 115: | ||
==Immunohistochemical stains== | ==Immunohistochemical stains== | ||
Features:<ref>{{cite journal |authors=Jiang W, Roma AA, Lai K, Carver P, Xiao SY, Liu X |title=Endometriosis involving the mucosa of the intestinal tract: a clinicopathologic study of 15 cases |journal=Mod Pathol |volume=26 |issue=9 |pages=1270–8 |date=September 2013 |pmid=23579618 |doi=10.1038/modpathol.2013.51 |url=}}</ref> | |||
*ER +ve | *ER +ve | ||
*[[CK7]] +ve | **Stains the epithelium. | ||
*[[CK20]] -ve - | *[[CK7]] +ve | ||
**Stains the epithelium. | |||
*[[CK20]] -ve | |||
**Used to exclude [[colorectal adenocarcinoma]]. | |||
*CDX2 -ve. | |||
**Used to exclude [[colorectal adenocarcinoma]]. | |||
*[[CD10]] +ve | |||
**Marks the stromal cells.<ref name=Ref_DCHH236>{{Ref DCHH|236}}</ref> | |||
==Sign out== | ==Sign out== | ||