Difference between revisions of "Cowper gland adenocarcinoma"
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'''Cowper gland adenocarcinoma''' is a [[cancer]] of the [[bulbourethral gland]]. | '''Cowper gland adenocarcinoma''', also '''bulbourethral gland adenocarcinoma''', is a [[cancer]] of the [[bulbourethral gland]]. It is very rare. | ||
==General== | |||
*Extremely rare - 9 reported cases in 2016.<ref>{{cite journal |authors=Zhang M, Pettaway C, Vikram R, Tamboli P |title=Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature |journal=Hum Pathol |volume=58 |issue= |pages=138–144 |date=December 2016 |pmid=27554206 |doi=10.1016/j.humpath.2016.07.027 |url=}}</ref> | |||
==Microscopic== | |||
Features:<ref name=WHOGU2022_187/><ref name=pmid1311394>{{cite journal |authors=Small JD, Albertsen PC, Graydon RJ, Ricci A, Sardella WV |title=Adenoid cystic carcinoma of Cowper's gland |journal=J Urol |volume=147 |issue=3 |pages=699–701 |date=March 1992 |pmid=1311394 |doi=10.1016/s0022-5347(17)37357-3 |url=}}</ref> | |||
*Cribriform ‡ or trabecular or solid pattern. | |||
*Cytologically bland morphology. | |||
Note: | |||
*‡ May have morphology of ''[[adenoid cystic carcinoma]]'' and have MYB-NFIB fusion.<ref name=WHOGU2022_187/><ref>{{cite journal |authors=Myers CE, Gatalica Z, Spinelli A, Castro M, Linden E, Sartor O, Sargent M |title=Metastatic Cancer of Cowper's Gland: A Rare Cancer Managed Successfully by Molecular Profiling |journal=Case Rep Oncol |volume=7 |issue=1 |pages=52–7 |date=January 2014 |pmid=24575017 |pmc=3934673 |doi=10.1159/000357972 |url=}}</ref> | |||
DDx: | |||
*[[Urothelial carcinoma]]. | |||
*[[Prostatic adenocarcinoma]]. | |||
*[[Clear cell adenocarcinoma of the urethra]]. | |||
==IHC== | |||
Features:<ref name=WHOGU2022_187>{{Ref WHOGU2022|187}}</ref> | |||
*CK7 +ve. | |||
*HWCK +ve. | |||
*PSA -ve. | |||
*PSAP -ve. | |||
*SMA -ve. | |||
*S-100 -ve. | |||
Note: Benign Cowper's glands are described as PSA +ve, PSAP -ve, HMWK +ve.<ref name=pmid9158679>{{Cite journal | last1 = Cina | first1 = SJ. | last2 = Silberman | first2 = MA. | last3 = Kahane | first3 = H. | last4 = Epstein | first4 = JI. | title = Diagnosis of Cowper's glands on prostate needle biopsy. | journal = Am J Surg Pathol | volume = 21 | issue = 5 | pages = 550-5 | month = May | year = 1997 | doi = | PMID = 9158679 }}</ref> | |||
==See also== | |||
*[[Bulbourethral gland]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Genitourinary pathology]] | |||
Latest revision as of 05:32, 4 November 2024
Cowper gland adenocarcinoma, also bulbourethral gland adenocarcinoma, is a cancer of the bulbourethral gland. It is very rare.
General
- Extremely rare - 9 reported cases in 2016.[1]
Microscopic
- Cribriform ‡ or trabecular or solid pattern.
- Cytologically bland morphology.
Note:
- ‡ May have morphology of adenoid cystic carcinoma and have MYB-NFIB fusion.[2][4]
DDx:
IHC
Features:[2]
- CK7 +ve.
- HWCK +ve.
- PSA -ve.
- PSAP -ve.
- SMA -ve.
- S-100 -ve.
Note: Benign Cowper's glands are described as PSA +ve, PSAP -ve, HMWK +ve.[5]
See also
References
- ↑ Zhang M, Pettaway C, Vikram R, Tamboli P (December 2016). "Adenoid cystic carcinoma of the urethra/Cowper's gland with concurrent high-grade prostatic adenocarcinoma: a detailed clinicopathologic case report and review of the literature". Hum Pathol 58: 138–144. doi:10.1016/j.humpath.2016.07.027. PMID 27554206.
- ↑ 2.0 2.1 2.2 WHO Classification of Tumours Editorial Board (2022). Urinary and Male Genital Tumours (5th ed.). Lyon: World Health Organization. pp. 187. ISBN 978-9283245124.
- ↑ Small JD, Albertsen PC, Graydon RJ, Ricci A, Sardella WV (March 1992). "Adenoid cystic carcinoma of Cowper's gland". J Urol 147 (3): 699–701. doi:10.1016/s0022-5347(17)37357-3. PMID 1311394.
- ↑ Myers CE, Gatalica Z, Spinelli A, Castro M, Linden E, Sartor O, Sargent M (January 2014). "Metastatic Cancer of Cowper's Gland: A Rare Cancer Managed Successfully by Molecular Profiling". Case Rep Oncol 7 (1): 52–7. doi:10.1159/000357972. PMC 3934673. PMID 24575017. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934673/.
- ↑ Cina, SJ.; Silberman, MA.; Kahane, H.; Epstein, JI. (May 1997). "Diagnosis of Cowper's glands on prostate needle biopsy.". Am J Surg Pathol 21 (5): 550-5. PMID 9158679.