Difference between revisions of "Amyloid in the seminal vesicles"

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[[Image:Seminal vesicles with amyloid -- low mag.jpg|right|thumb|Seminal vesicle with amyloid. [[H&E stain]].]]
'''Amyloid in the seminal vesicles''' is a relatively common histologic finding.   
'''Amyloid in the seminal vesicles''' is a relatively common histologic finding.   


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*Prevlance is 5-21% in two large prostatectomy series.<ref name=pmid22207431>{{Cite journal  | last1 = Argon | first1 = A. | last2 = Sımşır | first2 = A. | last3 = Sarsik | first3 = B. | last4 = Tuna | first4 = B. | last5 = Yörükoğlu | first5 = K. | last6 = Nıflıoğlu | first6 = GG. | last7 = Sen | first7 = S. | title = Amyloidosis of seminal vesicles; incidence and pathologic characteristics. | journal = Turk Patoloji Derg | volume = 28 | issue = 1 | pages = 44-8 | month =  | year = 2012 | doi = 10.5146/tjpath.2012.01096 | PMID = 22207431 }}</ref><ref name=pmid6849372>{{Cite journal  | last1 = Pitkänen | first1 = P. | last2 = Westermark | first2 = P. | last3 = Cornwell | first3 = GG. | last4 = Murdoch | first4 = W. | title = Amyloid of the seminal vesicles. A distinctive and common localized form of senile amyloidosis. | journal = Am J Pathol | volume = 110 | issue = 1 | pages = 64-9 | month = Jan | year = 1983 | doi =  | PMID = 6849372 }}</ref>
*Prevlance is 5-21% in two large prostatectomy series.<ref name=pmid22207431>{{Cite journal  | last1 = Argon | first1 = A. | last2 = Sımşır | first2 = A. | last3 = Sarsik | first3 = B. | last4 = Tuna | first4 = B. | last5 = Yörükoğlu | first5 = K. | last6 = Nıflıoğlu | first6 = GG. | last7 = Sen | first7 = S. | title = Amyloidosis of seminal vesicles; incidence and pathologic characteristics. | journal = Turk Patoloji Derg | volume = 28 | issue = 1 | pages = 44-8 | month =  | year = 2012 | doi = 10.5146/tjpath.2012.01096 | PMID = 22207431 }}</ref><ref name=pmid6849372>{{Cite journal  | last1 = Pitkänen | first1 = P. | last2 = Westermark | first2 = P. | last3 = Cornwell | first3 = GG. | last4 = Murdoch | first4 = W. | title = Amyloid of the seminal vesicles. A distinctive and common localized form of senile amyloidosis. | journal = Am J Pathol | volume = 110 | issue = 1 | pages = 64-9 | month = Jan | year = 1983 | doi =  | PMID = 6849372 }}</ref>


Significance/management:
===Significance/management===
*A paper by Yang ''et al.'' suggests it is not necessary to work-up further.<ref name=pmid23223033>{{Cite journal  | last1 = Yang | first1 = Z. | last2 = Laird | first2 = A. | last3 = Monaghan | first3 = A. | last4 = Seywright | first4 = M. | last5 = Ahmad | first5 = I. | last6 = Leung | first6 = HY. | title = Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies--are routine investigations for systemic amyloidosis warranted? | journal = Asian J Androl | volume = 15 | issue = 1 | pages = 149-51 | month = Jan | year = 2013 | doi = 10.1038/aja.2012.125 | PMID = 23223033 }}</ref>
*A paper by Yang ''et al.'' (looking at a small series) suggests seminal vesicle amyloid is ''not'' necessary to work-up further.<ref name=pmid23223033>{{Cite journal  | last1 = Yang | first1 = Z. | last2 = Laird | first2 = A. | last3 = Monaghan | first3 = A. | last4 = Seywright | first4 = M. | last5 = Ahmad | first5 = I. | last6 = Leung | first6 = HY. | title = Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies--are routine investigations for systemic amyloidosis warranted? | journal = Asian J Androl | volume = 15 | issue = 1 | pages = 149-51 | month = Jan | year = 2013 | doi = 10.1038/aja.2012.125 | PMID = 23223033 }}</ref>
 
Note:
*Amyloid in the prostate is rare and ''should'' be worked-up.<ref name=pmid32961226>{{cite journal |authors=Nevo A, Muchtar E, Stern KL, Moore JP, Cheney SM, Humphreys MR, Grogan M, Stanton ML |title=The Clinical Implication of Incidental Prostatic Amyloidosis |journal=Urology |volume=145 |issue= |pages=253–257 |date=November 2020 |pmid=32961226 |doi=10.1016/j.urology.2020.08.053 |url=}}</ref>
 
==Microscopic==
Features:
*Hyaline material with a "cracked" appearance surrounding the glandular component of the seminal vesicles.
 
===Images===
<gallery>
Image: Seminal vesicles with amyloid -- very low mag.jpg | SV with amyloid - very low  mag.
Image: Seminal vesicles with amyloid -- low mag.jpg | SV with amyloid - low  mag.
Image: Seminal vesicles with amyloid -- intermed mag.jpg | SV with amyloid - intermed.  mag.
Image: Seminal vesicles with amyloid -- high mag.jpg | SV with amyloid - high  mag.
Image: Seminal vesicles with amyloid -- very high mag.jpg | SV with amyloid - very high  mag.
</gallery>


==Stains==
==Stains==
*[[Congo red]] +ve.
*[[Congo red]] +ve.
===Images===
<gallery>
Image: Seminal vesicles with amyloid - congo red -- low mag.jpg | SV with amyloid - congo red - low  mag.
Image: Seminal vesicles with amyloid - congo red -- intermed mag.jpg | SV with amyloid - congo red - intermed.  mag.
</gallery>


==See also==
==See also==

Latest revision as of 03:23, 1 November 2024

Seminal vesicle with amyloid. H&E stain.

Amyloid in the seminal vesicles is a relatively common histologic finding.

General

  • Prevlance is 5-21% in two large prostatectomy series.[1][2]

Significance/management

  • A paper by Yang et al. (looking at a small series) suggests seminal vesicle amyloid is not necessary to work-up further.[3]

Note:

  • Amyloid in the prostate is rare and should be worked-up.[4]

Microscopic

Features:

  • Hyaline material with a "cracked" appearance surrounding the glandular component of the seminal vesicles.

Images

  • SV with amyloid - very low mag.

  • SV with amyloid - low mag.

  • SV with amyloid - intermed. mag.

  • SV with amyloid - high mag.

  • SV with amyloid - very high mag.

Stains

Images

  • SV with amyloid - congo red - low mag.

  • SV with amyloid - congo red - intermed. mag.

See also

References

  1. ↑ Argon, A.; Sımşır, A.; Sarsik, B.; Tuna, B.; Yörükoğlu, K.; Nıflıoğlu, GG.; Sen, S. (2012). "Amyloidosis of seminal vesicles; incidence and pathologic characteristics.". Turk Patoloji Derg 28 (1): 44-8. doi:10.5146/tjpath.2012.01096. PMID 22207431.
  2. ↑ Pitkänen, P.; Westermark, P.; Cornwell, GG.; Murdoch, W. (Jan 1983). "Amyloid of the seminal vesicles. A distinctive and common localized form of senile amyloidosis.". Am J Pathol 110 (1): 64-9. PMID 6849372.
  3. ↑ Yang, Z.; Laird, A.; Monaghan, A.; Seywright, M.; Ahmad, I.; Leung, HY. (Jan 2013). "Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies--are routine investigations for systemic amyloidosis warranted?". Asian J Androl 15 (1): 149-51. doi:10.1038/aja.2012.125. PMID 23223033.
  4. ↑ Nevo A, Muchtar E, Stern KL, Moore JP, Cheney SM, Humphreys MR, Grogan M, Stanton ML (November 2020). "The Clinical Implication of Incidental Prostatic Amyloidosis". Urology 145: 253–257. doi:10.1016/j.urology.2020.08.053. PMID 32961226.
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