48,479
edits
Difference between revisions of "Hibernoma"
Jump to navigation
Jump to search
no edit summary
(+cat.) |
|||
| (9 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Hibernoma1.jpg | |||
| Width = | |||
| Caption = Hibernoma. [[H&E stain]]. | |||
| Micro = large polygonal/oval cells with central & small nucleus; nucleoli typically prominent; cytoplasm multivacuolated, oval, eosinophilic, granular | |||
| Subtypes = | |||
| LMDDx = reaction to silicone implant | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = lobulated lesion, light-brown, usually extremities | |||
| Grossing = | |||
| Site = cervical-supraclavicular, periaortic - both thorax and the abdomen, perirenal; see ''[[soft tissue lesions|soft tissue]]'' - [[adipocytic lesions]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = typically young adults | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[Lipoma]] | |||
}} | |||
'''Hibernoma''', also '''tumour of [[brown fat]]''',<ref>{{Cite journal | last1 = SHUTE | first1 = D. | title = Tumours of brown fat. | journal = Can Med Assoc J | volume = 71 | issue = 5 | pages = 484-5 | month = Nov | year = 1954 | doi = | PMID = 13209434 }}</ref> is an uncommon [[adipocytic tumour]]. | |||
==General== | |||
*Consists of ''brown fat'' (present in the infants to generate heat).<ref name=Ref_WMSP605>{{Ref WMSP|605}}</ref> | |||
*Benign. | |||
*Usually asymptomatic.<ref name=pmid19131775>{{cite journal |author=Ahmed SA, Schuller I |title=Pediatric hibernoma: a case review |journal=J. Pediatr. Hematol. Oncol. |volume=30 |issue=12 |pages=900–1 |year=2008 |month=December |pmid=19131775 |doi=10.1097/MPH.0b013e318184e6dd |url=}}</ref> | |||
Epidemiology: | |||
*Young adults - disappears with age.<ref name=pmid31281288>{{cite journal |authors=Zoico E, Rubele S, De Caro A, Nori N, Mazzali G, Fantin F, Rossi A, Zamboni M |title=Brown and Beige Adipose Tissue and Aging |journal=Front Endocrinol (Lausanne) |volume=10 |issue= |pages=368 |date=2019 |pmid=31281288 |pmc=6595248 |doi=10.3389/fendo.2019.00368 |url=}}</ref> | |||
==Gross== | |||
*Well-circumscribed. | |||
*Lobulated and light-brown on sectioning. | |||
Locations:<ref name=pmid31281288/> | |||
*Cervical-supraclavicular. | |||
*Periaortic - both thorax and the abdomen. | |||
*Perirenal. | |||
==Microscopic== | |||
Features:<ref name=pmid9537018>{{cite journal |author=Chen DY, Wang CM, Chan HL |title=Hibernoma. Case report and literature review |journal=Dermatol Surg |volume=24 |issue=3 |pages=393–5 |year=1998 |month=March |pmid=9537018 |doi= |url=}}</ref> | |||
*Large polygonal/oval cells: | |||
**Nucleus - central & small.<ref>[http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675(06)70271-6]</ref> | |||
***Nucleoli typically prominent.<ref>[http://surgpathcriteria.stanford.edu/softfat/hibernoma/ http://surgpathcriteria.stanford.edu/softfat/hibernoma/]</ref> | |||
**Cytoplasm - multivacuolated, oval, eosinophilic, granular. | |||
*+/-Prominent blood vessels, central.<ref>URL: [http://radiographics.rsna.org/content/24/5/1433.full http://radiographics.rsna.org/content/24/5/1433.full]. Accessed on: 11 February 2013.</ref> | |||
DDx: | |||
*Reaction to silicone implant. | |||
===Images=== | |||
<gallery> | |||
Image:Hibernoma1.jpg | Hibernoma - high mag. (WC) | |||
Image:Hibernoma2.jpg | Hibernoma - intermed mag. (WC) | |||
Image:Hibernoma3.jpg | Hibernoma - low mag. (WC) | |||
</gallery> | |||
==See also== | |||
*[[Adipocytic tumours]]. | |||
*[[Lipoma]]. | |||
*[[Brown tumour]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Adipocytic tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||