Difference between revisions of "Sertoli cell tumour"

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#redirect [[Testis#Sertoli_cell_tumour]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Sertoli_cell_tumour_high_mag.jpg
| Width      =
| Caption    = Sertoli cell tumour. [[H&E stain]].
| Synonyms  =
| Micro      = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin
| Subtypes  =
| LMDDx      =  [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]]
| Stains    =
| IHC        = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve,
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[testis]], [[ovary]]
| Assdx      =
| Syndromes  = [[Peutz-Jeghers syndrome]], [[Carney complex]]
| Clinicalhx =
| Signs      = testicular mass
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. It is occasionally seen in women.
 
==General==
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells).
*Occasionally seen in women.<ref name=pmid20349797>{{Cite journal  | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Petrakopoulou | first2 = N. | last3 = Tepelenis | first3 = N. | last4 = Savvaidou | first4 = V. | last5 = Manoloudaki | first5 = K. | last6 = Katsoulis | first6 = M. | title = Pure Sertoli cell tumor. a case report and review of the literature. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 1 | pages = 117-9 | month =  | year = 2010 | doi =  | PMID = 20349797 }}</ref>
 
May be seen in several syndrome - esp. if there is calcification:
*[[Carney complex]].<ref name=pmid21047926>{{Cite journal  | last1 = Libé | first1 = R. | last2 = Horvath | first2 = A. | last3 = Vezzosi | first3 = D. | last4 = Fratticci | first4 = A. | last5 = Coste | first5 = J. | last6 = Perlemoine | first6 = K. | last7 = Ragazzon | first7 = B. | last8 = Guillaud-Bataille | first8 = M. | last9 = Groussin | first9 = L. | title = Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. | journal = J Clin Endocrinol Metab | volume = 96 | issue = 1 | pages = E208-14 | month = Jan | year = 2011 | doi = 10.1210/jc.2010-1704 | PMID = 21047926 }}</ref>
*[[Peutz-Jeghers syndrome]].<ref name=pmid22732638>{{Cite journal  | last1 = Gourgari | first1 = E. | last2 = Saloustros | first2 = E. | last3 = Stratakis | first3 = CA. | title = Large-cell calcifying Sertoli cell tumors of the testes in pediatrics. | journal = Curr Opin Pediatr | volume = 24 | issue = 4 | pages = 518-22 | month = Aug | year = 2012 | doi = 10.1097/MOP.0b013e328355a279 | PMID = 22732638 }}</ref>
 
==Microscopic==
Features:
*Groups of cells in ''cords'' or ''trabeculae'' (beam-like arrangement).
*Cells have:
**Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
**Slightly irregular nucleoli.
**Granular irregular appearing chromatin.
 
Negatives:
*Mitoses are rare.
*No significant nuclear atypia.
 
DDx:
*[[Granulosa cell tumour]] - may be very similar.  Often has nuclear grooves.
*Epithelioid [[adenomatoid tumour]].
*[[Sertoli cell nodule]].
*[[Sertoli-Leydig tumour]] - esp. in [[ovary]].
 
===Images===
<gallery>
Image:Sertoli_cell_tumour_high_mag.jpg | Sertoli cell tumour - high mag. (WC)
Image:Sertoli_cell_tumour_low_mag.jpg | Sertoli cell tumour - low mag. (WC)
</gallery>
www:
*[http://path.upmc.edu/cases/case275/micro.html Sertoli cell tumour with calcification in Carney complex - several images (upmc.edu)].
 
==IHC==
*Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>).
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>).
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref>
**Negative beta-catenin should make one consider other diagnoses.{{fact}}
**May be negative in malignant sertoli cell tumours.
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref>
**Germ cell tumours -ve.
 
Others:
*WT-1 +ve.<ref name=pmid17721194>{{Cite journal  | last1 = Zhao | first1 = C. | last2 = Bratthauer | first2 = GL. | last3 = Barner | first3 = R. | last4 = Vang | first4 = R. | title = Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1378-86 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e3180339961 | PMID = 17721194 }}</ref>
 
==See also==
*[[Leydig cell tumour]].
*[[Sertoli-Leydig tumour]].
*[[Sex cord-stromal tumours]]
*[[Testis]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Testis]]

Latest revision as of 15:02, 18 April 2024

Sertoli cell tumour
Diagnosis in short

Sertoli cell tumour. H&E stain.
LM groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin
LM DDx granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour
IHC SF-1 +ve, alpha-inhibin +ve, calretinin +ve/-ve,
Site testis, ovary
Syndromes Peutz-Jeghers syndrome, Carney complex
Signs testicular mass
Prevalence uncommon

Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis. It is occasionally seen in women.

General

  • Arises from Sertoli cells (AKA nurse cells).
  • Occasionally seen in women.[1]

May be seen in several syndrome - esp. if there is calcification:

Microscopic

Features:

  • Groups of cells in cords or trabeculae (beam-like arrangement).
  • Cells have:
    • Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
    • Slightly irregular nucleoli.
    • Granular irregular appearing chromatin.

Negatives:

  • Mitoses are rare.
  • No significant nuclear atypia.

DDx:

Images

  • Sertoli cell tumour - high mag. (WC)

  • Sertoli cell tumour - low mag. (WC)

www:

IHC

  • Alpha-inhibin +ve (~95% of cases[4]).
  • Calretinin +ve (~55% of cases[4]).
  • Beta-catenin +ve (nuclear).[5]
    • Negative beta-catenin should make one consider other diagnoses.[citation needed]
    • May be negative in malignant sertoli cell tumours.
  • SF-1 +ve.[6]
    • Germ cell tumours -ve.

Others:

See also

References

  1. ↑ Zizi-Sermpetzoglou, A.; Petrakopoulou, N.; Tepelenis, N.; Savvaidou, V.; Manoloudaki, K.; Katsoulis, M. (2010). "Pure Sertoli cell tumor. a case report and review of the literature.". Eur J Gynaecol Oncol 31 (1): 117-9. PMID 20349797.
  2. ↑ Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.
  3. ↑ Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.
  4. ↑ 4.0 4.1 4.2 Zhao, C.; Bratthauer, GL.; Barner, R.; Vang, R. (Sep 2007). "Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.". Am J Surg Pathol 31 (9): 1378-86. doi:10.1097/PAS.0b013e3180339961. PMID 17721194.
  5. ↑ Zhang C, Ulbright TM (October 2015). "Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases". Am J Surg Pathol 39 (10): 1390–4. doi:10.1097/PAS.0000000000000455. PMID 26034868.
  6. ↑ Sangoi AR, McKenney JK, Brooks JD, Higgins JP (July 2013). "Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases". Appl Immunohistochem Mol Morphol 21 (4): 318–21. doi:10.1097/PAI.0b013e318277cf5a. PMID 23165333.
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