Difference between revisions of "Sertoli cell tumour"
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'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Sertoli_cell_tumour_high_mag.jpg | |||
| Width = | |||
| Caption = Sertoli cell tumour. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | |||
| Subtypes = | |||
| LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]] | |||
| Stains = | |||
| IHC = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve, | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[testis]], [[ovary]] | |||
| Assdx = | |||
| Syndromes = [[Peutz-Jeghers syndrome]], [[Carney complex]] | |||
| Clinicalhx = | |||
| Signs = testicular mass | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. It is occasionally seen in women. | |||
==General== | ==General== | ||
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | *Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | ||
*Occasionally seen in women.<ref name=pmid20349797>{{Cite journal | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Petrakopoulou | first2 = N. | last3 = Tepelenis | first3 = N. | last4 = Savvaidou | first4 = V. | last5 = Manoloudaki | first5 = K. | last6 = Katsoulis | first6 = M. | title = Pure Sertoli cell tumor. a case report and review of the literature. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 1 | pages = 117-9 | month = | year = 2010 | doi = | PMID = 20349797 }}</ref> | |||
May be seen in several syndrome - esp. if there is calcification: | May be seen in several syndrome - esp. if there is calcification: | ||
*[[Carney complex]].<ref name=pmid21047926>{{Cite journal | last1 = Libé | first1 = R. | last2 = Horvath | first2 = A. | last3 = Vezzosi | first3 = D. | last4 = Fratticci | first4 = A. | last5 = Coste | first5 = J. | last6 = Perlemoine | first6 = K. | last7 = Ragazzon | first7 = B. | last8 = Guillaud-Bataille | first8 = M. | last9 = Groussin | first9 = L. | title = Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. | journal = J Clin Endocrinol Metab | volume = 96 | issue = 1 | pages = E208-14 | month = Jan | year = 2011 | doi = 10.1210/jc.2010-1704 | PMID = 21047926 }}</ref> | *[[Carney complex]].<ref name=pmid21047926>{{Cite journal | last1 = Libé | first1 = R. | last2 = Horvath | first2 = A. | last3 = Vezzosi | first3 = D. | last4 = Fratticci | first4 = A. | last5 = Coste | first5 = J. | last6 = Perlemoine | first6 = K. | last7 = Ragazzon | first7 = B. | last8 = Guillaud-Bataille | first8 = M. | last9 = Groussin | first9 = L. | title = Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype. | journal = J Clin Endocrinol Metab | volume = 96 | issue = 1 | pages = E208-14 | month = Jan | year = 2011 | doi = 10.1210/jc.2010-1704 | PMID = 21047926 }}</ref> | ||
*[[Peutz-Jeghers syndrome]]. | *[[Peutz-Jeghers syndrome]].<ref name=pmid22732638>{{Cite journal | last1 = Gourgari | first1 = E. | last2 = Saloustros | first2 = E. | last3 = Stratakis | first3 = CA. | title = Large-cell calcifying Sertoli cell tumors of the testes in pediatrics. | journal = Curr Opin Pediatr | volume = 24 | issue = 4 | pages = 518-22 | month = Aug | year = 2012 | doi = 10.1097/MOP.0b013e328355a279 | PMID = 22732638 }}</ref> | ||
==Microscopic== | ==Microscopic== | ||
| Line 24: | Line 56: | ||
*Epithelioid [[adenomatoid tumour]]. | *Epithelioid [[adenomatoid tumour]]. | ||
*[[Sertoli cell nodule]]. | *[[Sertoli cell nodule]]. | ||
*[[Sertoli-Leydig tumour]] - esp. in [[ovary]]. | |||
===Images=== | ===Images=== | ||
| Line 34: | Line 67: | ||
==IHC== | ==IHC== | ||
*Alpha-inhibin +ve. ( | *Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>). | ||
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>). | |||
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref> | |||
**Negative beta-catenin should make one consider other diagnoses.{{fact}} | |||
**May be negative in malignant sertoli cell tumours. | |||
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref> | |||
**Germ cell tumours -ve. | |||
Others: | |||
*WT-1 +ve.<ref name=pmid17721194>{{Cite journal | last1 = Zhao | first1 = C. | last2 = Bratthauer | first2 = GL. | last3 = Barner | first3 = R. | last4 = Vang | first4 = R. | title = Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1378-86 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e3180339961 | PMID = 17721194 }}</ref> | |||
==See also== | ==See also== | ||
*[[Leydig cell tumour]]. | *[[Leydig cell tumour]]. | ||
*[[Sertoli-Leydig tumour]]. | *[[Sertoli-Leydig tumour]]. | ||
*[[Sex cord-stromal tumours]] | |||
*[[Testis]]. | *[[Testis]]. | ||
Latest revision as of 15:02, 18 April 2024
| Sertoli cell tumour | |
|---|---|
| Diagnosis in short | |
 Sertoli cell tumour. H&E stain. | |
|
| |
| LM | groups of cells in cords or trabeculae, cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin |
| LM DDx | granulosa cell tumour, epithelioid adenomatoid tumour, sertoli cell nodule, Sertoli-Leydig tumour |
| IHC | SF-1 +ve, alpha-inhibin +ve, calretinin +ve/-ve, |
| Site | testis, ovary |
|
| |
| Syndromes | Peutz-Jeghers syndrome, Carney complex |
|
| |
| Signs | testicular mass |
| Prevalence | uncommon |
Sertoli cell tumour is a sex cord-stromal tumour typically found in the testis. It is occasionally seen in women.
General
May be seen in several syndrome - esp. if there is calcification:
Microscopic
Features:
- Groups of cells in cords or trabeculae (beam-like arrangement).
- Cells have:
- Light staining bubbly cytoplasm +/- large cytoplasmic vacuoles.
- Slightly irregular nucleoli.
- Granular irregular appearing chromatin.
Negatives:
- Mitoses are rare.
- No significant nuclear atypia.
DDx:
- Granulosa cell tumour - may be very similar. Often has nuclear grooves.
- Epithelioid adenomatoid tumour.
- Sertoli cell nodule.
- Sertoli-Leydig tumour - esp. in ovary.
Images
Sertoli cell tumour - high mag. (WC)
Sertoli cell tumour - low mag. (WC)
www:
IHC
- Alpha-inhibin +ve (~95% of cases[4]).
- Calretinin +ve (~55% of cases[4]).
- Beta-catenin +ve (nuclear).[5]
- Negative beta-catenin should make one consider other diagnoses.[citation needed]
- May be negative in malignant sertoli cell tumours.
- SF-1 +ve.[6]
- Germ cell tumours -ve.
Others:
- WT-1 +ve.[4]
See also
References
- ↑ Zizi-Sermpetzoglou, A.; Petrakopoulou, N.; Tepelenis, N.; Savvaidou, V.; Manoloudaki, K.; Katsoulis, M. (2010). "Pure Sertoli cell tumor. a case report and review of the literature.". Eur J Gynaecol Oncol 31 (1): 117-9. PMID 20349797.
- ↑ Libé, R.; Horvath, A.; Vezzosi, D.; Fratticci, A.; Coste, J.; Perlemoine, K.; Ragazzon, B.; Guillaud-Bataille, M. et al. (Jan 2011). "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype.". J Clin Endocrinol Metab 96 (1): E208-14. doi:10.1210/jc.2010-1704. PMID 21047926.
- ↑ Gourgari, E.; Saloustros, E.; Stratakis, CA. (Aug 2012). "Large-cell calcifying Sertoli cell tumors of the testes in pediatrics.". Curr Opin Pediatr 24 (4): 518-22. doi:10.1097/MOP.0b013e328355a279. PMID 22732638.
- ↑ 4.0 4.1 4.2 Zhao, C.; Bratthauer, GL.; Barner, R.; Vang, R. (Sep 2007). "Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor.". Am J Surg Pathol 31 (9): 1378-86. doi:10.1097/PAS.0b013e3180339961. PMID 17721194.
- ↑ Zhang C, Ulbright TM (October 2015). "Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases". Am J Surg Pathol 39 (10): 1390–4. doi:10.1097/PAS.0000000000000455. PMID 26034868.
- ↑ Sangoi AR, McKenney JK, Brooks JD, Higgins JP (July 2013). "Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases". Appl Immunohistochem Mol Morphol 21 (4): 318–21. doi:10.1097/PAI.0b013e318277cf5a. PMID 23165333.