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Difference between revisions of "Sertoli cell tumour"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Sertoli_cell_tumour_high_mag.jpg | | Image = Sertoli_cell_tumour_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Sertoli cell tumour. [[H&E stain]]. | | Caption = Sertoli cell tumour. [[H&E stain]]. | ||
| Line 7: | Line 7: | ||
| Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | | Micro = groups of cells in ''cords'' or ''trabeculae'', cells have light staining bubbly cytoplasm +/- large cytoplasmic vacuoles, slightly irregular nucleoli, granular irregular appearing chromatin | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]] | | LMDDx = [[granulosa cell tumour]], epithelioid [[adenomatoid tumour]], [[sertoli cell nodule]], [[Sertoli-Leydig tumour]] | ||
| Stains = | | Stains = | ||
| IHC = alpha-inhibin, calretinin | | IHC = [[SF-1]] +ve, alpha-inhibin +ve, calretinin +ve/-ve, | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
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| Tx = | | Tx = | ||
}} | }} | ||
'''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. | '''Sertoli cell tumour''' is a sex cord-stromal tumour typically found in the [[testis]]. It is occasionally seen in women. | ||
==General== | ==General== | ||
*Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | *Arises from ''Sertoli cells'' ([[AKA]] nurse cells). | ||
*Occasionally seen in women.<ref name=pmid20349797>{{Cite journal | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Petrakopoulou | first2 = N. | last3 = Tepelenis | first3 = N. | last4 = Savvaidou | first4 = V. | last5 = Manoloudaki | first5 = K. | last6 = Katsoulis | first6 = M. | title = Pure Sertoli cell tumor. a case report and review of the literature. | journal = Eur J Gynaecol Oncol | volume = 31 | issue = 1 | pages = 117-9 | month = | year = 2010 | doi = | PMID = 20349797 }}</ref> | |||
May be seen in several syndrome - esp. if there is calcification: | May be seen in several syndrome - esp. if there is calcification: | ||
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*Epithelioid [[adenomatoid tumour]]. | *Epithelioid [[adenomatoid tumour]]. | ||
*[[Sertoli cell nodule]]. | *[[Sertoli cell nodule]]. | ||
*[[Sertoli-Leydig tumour]] - esp. in [[ovary]]. | |||
===Images=== | ===Images=== | ||
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==IHC== | ==IHC== | ||
*Alpha-inhibin +ve. ( | *Alpha-inhibin +ve (~95% of cases<ref name=pmid17721194/>). | ||
*[[Calretinin]] +ve (~55% of cases<ref name=pmid17721194/>). | |||
*Beta-catenin +ve (nuclear).<ref>{{cite journal |authors=Zhang C, Ulbright TM |title=Nuclear Localization of β-Catenin in Sertoli Cell Tumors and Other Sex Cord-Stromal Tumors of the Testis: An Immunohistochemical Study of 87 Cases |journal=Am J Surg Pathol |volume=39 |issue=10 |pages=1390–4 |date=October 2015 |pmid=26034868 |doi=10.1097/PAS.0000000000000455 |url=}}</ref> | |||
**Negative beta-catenin should make one consider other diagnoses.{{fact}} | |||
**May be negative in malignant sertoli cell tumours. | |||
*[[SF-1]] +ve.<ref name=pmid23165333>{{cite journal |authors=Sangoi AR, McKenney JK, Brooks JD, Higgins JP |title=Evaluation of SF-1 expression in testicular germ cell tumors: a tissue microarray study of 127 cases |journal=Appl Immunohistochem Mol Morphol |volume=21 |issue=4 |pages=318–21 |date=July 2013 |pmid=23165333 |doi=10.1097/PAI.0b013e318277cf5a |url=}}</ref> | |||
**Germ cell tumours -ve. | |||
Others: | |||
*WT-1 +ve.<ref name=pmid17721194>{{Cite journal | last1 = Zhao | first1 = C. | last2 = Bratthauer | first2 = GL. | last3 = Barner | first3 = R. | last4 = Vang | first4 = R. | title = Diagnostic utility of WT1 immunostaining in ovarian sertoli cell tumor. | journal = Am J Surg Pathol | volume = 31 | issue = 9 | pages = 1378-86 | month = Sep | year = 2007 | doi = 10.1097/PAS.0b013e3180339961 | PMID = 17721194 }}</ref> | |||
==See also== | ==See also== | ||
*[[Leydig cell tumour]]. | *[[Leydig cell tumour]]. | ||
*[[Sertoli-Leydig tumour]]. | *[[Sertoli-Leydig tumour]]. | ||
*[[Sex cord-stromal tumours]] | |||
*[[Testis]]. | *[[Testis]]. | ||