Difference between revisions of "Collecting duct carcinoma"

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#redirect [[Kidney_tumours#Collecting_duct_carcinoma]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Collecting duct carcinoma - 2 WBAL.tif
| Width      =
| Caption    = Collecting duct carcinoma. (WC/George Netto)
| Micro      = tubular structures with tapered ends, [[hobnail pattern]], nuclear pleomorphism), high mitotic rate
| Subtypes  =
| LMDDx      = [[papillary renal cell carcinoma]], [[urothelial carcinoma]] (with glandular differentiation), metastatic [[adenocarcinoma]], [[renal medullary carcinoma]], [[ALK-rearranged renal cell carcinoma]]
| Stains    =
| IHC        = CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve
| EM        =
| Molecular  =
| IF        =
| Gross      = medullary tumour
| Grossing  = [[total nephrectomy for tumour grossing]], [[partial nephrectomy grossing]]
| Staging    = [[kidney cancer staging]]
| Site      = [[kidney]] - see [[kidney tumours]]
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = very rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor
| Other      =
| ClinDDx    = other [[renal tumours]]
}}
'''Collecting duct carcinoma''', also known as '''Bellini duct carcinoma'''<ref name=pmid21393935>{{Cite journal  | last1 = Stamatiou | first1 = K. | last2 = Zizi-Sermpetzoglou | first2 = A. | title = Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis. | journal = Indian J Pathol Microbiol | volume = 54 | issue = 1 | pages = 229-30 | month =  | year =  | doi = 10.4103/0377-4929.77425 | PMID = 21393935 }}</ref> and '''carcinoma of the collecting ducts of Bellini''', is a rare aggressive [[kidney tumour]].
 
It should '''not''' be confused with [[tubulocystic carcinoma of the kidney]] (also known as ''low-grade collecting duct carcinoma'').
 
==General==
*Rare.
*Poor prognosis.
*Usually central location.
*Typically young adults.
 
==Gross==
*Medullary location - as opposed to cortical.<ref>{{Cite journal  | last1 = López | first1 = JI. | last2 = Larrinaga | first2 = G. | last3 = Kuroda | first3 = N. | last4 = Angulo | first4 = JC. | title = The normal and pathologic renal medulla: a comprehensive overview. | journal = Pathol Res Pract | volume = 211 | issue = 4 | pages = 271-80 | month = Apr | year = 2015 | doi = 10.1016/j.prp.2014.12.009 | PMID = 25595996 }}</ref>
==Microscopic==
Features:<ref name=Ref_GUP295>{{Ref GUP|295}}</ref>
*Tubular structures with tapered ends.
**May be described as ''tubulopapillary''.
*[[Hobnail pattern]] - cell width smaller at basement membrane than free surface.<ref name=Ref_PBoD1018>{{Ref PBoD|1018}}</ref>
*High grade nuclear features (nuclear pleomorphism).
*High mitotic rate.
 
Notes:
*Benign urothelium must present to excluded urothelial carcinoma.
*Desmoplastic stroma may be prominent.
 
DDx:
*[[Papillary renal cell carcinoma]].
*[[Urothelial carcinoma]] with glandular differentiation.
*Metastatic [[adenocarcinoma]].
*[[Renal medullary carcinoma]] - typically younger, sickle cell trait.
*[[Hereditary leiomyomatosis and renal cell carcinoma syndrome-associated renal cell carcinoma]].
 
===Images===
<gallery>
Image: Collecting duct carcinoma - 1 WBAL.tif | CDC - 1 (WC/Netto)
Image: Collecting duct carcinoma - 2 WBAL.tif | CDC - 2 (WC/Netto)
Image: Collecting duct carcinoma - 5 WBAL.tif | CDC - 5 (WC/Netto)
</gallery>
====www====
*[http://images.rsna.org/index.html?doi=10.1148/rg.266065010&fig=F17 CDC (rsna.org)].<ref name=pmid17102051>{{Cite journal  | last1 = Prasad | first1 = SR. | last2 = Humphrey | first2 = PA. | last3 = Catena | first3 = JR. | last4 = Narra | first4 = VR. | last5 = Srigley | first5 = JR. | last6 = Cortez | first6 = AD. | last7 = Dalrymple | first7 = NC. | last8 = Chintapalli | first8 = KN. | title = Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation. | journal = Radiographics | volume = 26 | issue = 6 | pages = 1795-806; discussion 1806-10 | month =  | year =  | doi = 10.1148/rg.266065010 | PMID = 17102051 }}</ref>
 
==IHC==
Features:<ref name=pmid19494850>{{Cite journal  | last1 = Srigley | first1 = JR. | last2 = Delahunt | first2 = B. | title = Uncommon and recently described renal carcinomas. | journal = Mod Pathol | volume = 22 Suppl 2 | issue =  | pages = S2-S23 | month = Jun | year = 2009 | doi = 10.1038/modpathol.2009.70 | PMID = 19494850 | URL = http://www.nature.com/modpathol/journal/v22/n2s/full/modpathol200970a.html }}</ref>
*HMWCK +ve.
*LMWCK +ve.
*CD117 +ve.
*E-cadherin +ve.
*CD10 -ve.
*AMACR -ve.
*[[PAX8]] +ve.<ref name=pmid20463571>{{Cite journal  | last1 = Albadine | first1 = R. | last2 = Schultz | first2 = L. | last3 = Illei | first3 = P. | last4 = Ertoy | first4 = D. | last5 = Hicks | first5 = J. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | last8 = Netto | first8 = GJ. | title = PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. | journal = Am J Surg Pathol | volume = 34 | issue = 7 | pages = 965-9 | month = Jul | year = 2010 | doi = 10.1097/PAS.0b013e3181dc5e8a | PMID = 20463571 }}</ref>
 
UCC:
*CK20 +ve.<ref name=pmid19494850/>
*p63 +ve.<ref name=pmid20463571>{{Cite journal  | last1 = Albadine | first1 = R. | last2 = Schultz | first2 = L. | last3 = Illei | first3 = P. | last4 = Ertoy | first4 = D. | last5 = Hicks | first5 = J. | last6 = Sharma | first6 = R. | last7 = Epstein | first7 = JI. | last8 = Netto | first8 = GJ. | title = PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract. | journal = Am J Surg Pathol | volume = 34 | issue = 7 | pages = 965-9 | month = Jul | year = 2010 | doi = 10.1097/PAS.0b013e3181dc5e8a | PMID = 20463571 }}</ref>
*CK5/6 +ve.
*PAX8 -ve.<ref name=pmid20463571/>
 
Others:
*CK7 +ve.<ref name=pmid12613443>{{Cite journal  | last1 = Kim | first1 = MK. | last2 = Kim | first2 = S. | title = Immunohistochemical profile of common epithelial neoplasms arising in the kidney. | journal = Appl Immunohistochem Mol Morphol | volume = 10 | issue = 4 | pages = 332-8 | month = Dec | year = 2002 | doi =  | PMID = 12613443 }}</ref>
*UEA-1 +ve.
**-ve in [[HLRCC]].<ref name=pmid17895761>{{Cite journal  | last1 = Merino | first1 = MJ. | last2 = Torres-Cabala | first2 = C. | last3 = Pinto | first3 = P. | last4 = Linehan | first4 = WM. | title = The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome. | journal = Am J Surg Pathol | volume = 31 | issue = 10 | pages = 1578-85 | month = Oct | year = 2007 | doi = 10.1097/PAS.0b013e31804375b8 | PMID = 17895761 }}</ref>
 
==See also==
*[[Kidney tumours]].
*[[Tubulocystic carcinoma of the kidney]] (low-grade collecting duct carcinoma).
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Kidney tumours]]

Latest revision as of 15:10, 20 March 2024

Collecting duct carcinoma
Diagnosis in short

Collecting duct carcinoma. (WC/George Netto)
LM tubular structures with tapered ends, hobnail pattern, nuclear pleomorphism), high mitotic rate
LM DDx papillary renal cell carcinoma, urothelial carcinoma (with glandular differentiation), metastatic adenocarcinoma, renal medullary carcinoma, ALK-rearranged renal cell carcinoma
IHC CD117 +ve, CK7 +ve, PAX8 +ve, CD10 -ve, AMACR -ve, p63 -ve
Gross medullary tumour
Grossing notes total nephrectomy for tumour grossing, partial nephrectomy grossing
Staging kidney cancer staging
Site kidney - see kidney tumours
Prevalence very rare
Prognosis poor
Clin. DDx other renal tumours

Collecting duct carcinoma, also known as Bellini duct carcinoma[1] and carcinoma of the collecting ducts of Bellini, is a rare aggressive kidney tumour.

It should not be confused with tubulocystic carcinoma of the kidney (also known as low-grade collecting duct carcinoma).

General

  • Rare.
  • Poor prognosis.
  • Usually central location.
  • Typically young adults.

Gross

  • Medullary location - as opposed to cortical.[2]

Microscopic

Features:[3]

  • Tubular structures with tapered ends.
    • May be described as tubulopapillary.
  • Hobnail pattern - cell width smaller at basement membrane than free surface.[4]
  • High grade nuclear features (nuclear pleomorphism).
  • High mitotic rate.

Notes:

  • Benign urothelium must present to excluded urothelial carcinoma.
  • Desmoplastic stroma may be prominent.

DDx:

Images

  • CDC - 1 (WC/Netto)

  • CDC - 2 (WC/Netto)

  • CDC - 5 (WC/Netto)

www

IHC

Features:[6]

  • HMWCK +ve.
  • LMWCK +ve.
  • CD117 +ve.
  • E-cadherin +ve.
  • CD10 -ve.
  • AMACR -ve.
  • PAX8 +ve.[7]

UCC:

  • CK20 +ve.[6]
  • p63 +ve.[7]
  • CK5/6 +ve.
  • PAX8 -ve.[7]

Others:

See also

References

  1. ↑ Stamatiou, K.; Zizi-Sermpetzoglou, A.. "Bellini duct carcinoma accidentally found upon investigation of uric acid lithiasis.". Indian J Pathol Microbiol 54 (1): 229-30. doi:10.4103/0377-4929.77425. PMID 21393935.
  2. ↑ López, JI.; Larrinaga, G.; Kuroda, N.; Angulo, JC. (Apr 2015). "The normal and pathologic renal medulla: a comprehensive overview.". Pathol Res Pract 211 (4): 271-80. doi:10.1016/j.prp.2014.12.009. PMID 25595996.
  3. ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 295. ISBN 978-0443066771.
  4. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1018. ISBN 0-7216-0187-1.
  5. ↑ Prasad, SR.; Humphrey, PA.; Catena, JR.; Narra, VR.; Srigley, JR.; Cortez, AD.; Dalrymple, NC.; Chintapalli, KN.. "Common and uncommon histologic subtypes of renal cell carcinoma: imaging spectrum with pathologic correlation.". Radiographics 26 (6): 1795-806; discussion 1806-10. doi:10.1148/rg.266065010. PMID 17102051.
  6. ↑ 6.0 6.1 Srigley, JR.; Delahunt, B. (Jun 2009). "Uncommon and recently described renal carcinomas.". Mod Pathol 22 Suppl 2: S2-S23. doi:10.1038/modpathol.2009.70. PMID 19494850.
  7. ↑ 7.0 7.1 7.2 Albadine, R.; Schultz, L.; Illei, P.; Ertoy, D.; Hicks, J.; Sharma, R.; Epstein, JI.; Netto, GJ. (Jul 2010). "PAX8 (+)/p63 (-) immunostaining pattern in renal collecting duct carcinoma (CDC): a useful immunoprofile in the differential diagnosis of CDC versus urothelial carcinoma of upper urinary tract.". Am J Surg Pathol 34 (7): 965-9. doi:10.1097/PAS.0b013e3181dc5e8a. PMID 20463571.
  8. ↑ Kim, MK.; Kim, S. (Dec 2002). "Immunohistochemical profile of common epithelial neoplasms arising in the kidney.". Appl Immunohistochem Mol Morphol 10 (4): 332-8. PMID 12613443.
  9. ↑ Merino, MJ.; Torres-Cabala, C.; Pinto, P.; Linehan, WM. (Oct 2007). "The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome.". Am J Surg Pathol 31 (10): 1578-85. doi:10.1097/PAS.0b013e31804375b8. PMID 17895761.
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