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Difference between revisions of "Pleomorphic adenoma"
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{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Pleomorphic_adenoma_%281%29_parotid_gland.jpg | | Image = Pleomorphic_adenoma_%281%29_parotid_gland.jpg | ||
| Width = | | Width = | ||
| Caption = Pleomorphic adenoma. [[H&E stain]]. | | Caption = Pleomorphic adenoma. [[H&E stain]]. (WC/KGH) | ||
| Synonyms = benign mixed tumour | |||
| Micro = proliferation of myoepithelium in a mesenchymal stroma +/- epithelium; cells in ducts = epithelial, cells not in ducts = myoepithelial, mesenchymal stroma = [[chondromyxoid stroma|chondroid]] stroma (specific), others (require epithelium) mucochondroid, hyalinized, osseous, fatty, myxoid | | Micro = proliferation of myoepithelium in a mesenchymal stroma +/- epithelium; cells in ducts = epithelial, cells not in ducts = myoepithelial, mesenchymal stroma = [[chondromyxoid stroma|chondroid]] stroma (specific), others (require epithelium) mucochondroid, hyalinized, osseous, fatty, myxoid | ||
| Subtypes = | | Subtypes = | ||
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'''Pleomorphic adenoma''', abbreviated '''PA''', is a very common benign [[salivary gland]] tumour. | '''Pleomorphic adenoma''', abbreviated '''PA''', is a very common benign [[salivary gland]] tumour. | ||
It is also known as '''benign mixed tumour'''.<ref>URL: [http://radiopaedia.org/articles/pleomorphic-adenoma-of-the-salivary-glands http://radiopaedia.org/articles/pleomorphic-adenoma-of-the-salivary-glands]. Accessed on: 30 March 2016.</ref><ref name=pmid19926180>{{Cite journal | last1 = Lingam | first1 = RK. | last2 = Daghir | first2 = AA. | last3 = Nigar | first3 = E. | last4 = Abbas | first4 = SA. | last5 = Kumar | first5 = M. | title = Pleomorphic adenoma (benign mixed tumour) of the salivary glands: its diverse clinical, radiological, and histopathological presentation. | journal = Br J Oral Maxillofac Surg | volume = 49 | issue = 1 | pages = 14-20 | month = Jan | year = 2011 | doi = 10.1016/j.bjoms.2009.09.014 | PMID = 19926180 }}</ref> | |||
==General== | ==General== | ||
Features: | Features: | ||
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====Case 1==== | ====Case 1==== | ||
<gallery> | <gallery> | ||
Image:Pleomorphic_adenoma_%281%29_parotid_gland.jpg | PA. (WC) | Image:Pleomorphic_adenoma_%281%29_parotid_gland.jpg | PA. (WC/KGH) | ||
Image:Pleomorphic_adenoma_%282%29_parotid_gland.jpg | PA. (WC) | Image:Pleomorphic_adenoma_%282%29_parotid_gland.jpg | PA. (WC/KGH) | ||
Image:Pleomorphic_adenoma_%283%29_parotid_gland.jpg | PA. (WC) | Image:Pleomorphic_adenoma_%283%29_parotid_gland.jpg | PA. (WC/KGH) | ||
Image:Pleomorphic_adenoma_%284%29_parotid_gland.jpg | PA. (WC) | Image:Pleomorphic_adenoma_%284%29_parotid_gland.jpg | PA. (WC/KGH) | ||
</gallery> | </gallery> | ||
====Case 2==== | ====Case 2==== | ||
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not identified. Mitotic activity is not apparent. Unremarkable parotid gland and a | not identified. Mitotic activity is not apparent. Unremarkable parotid gland and a | ||
morphologically benign lymph node are present. Ink is seen on the tumour. | morphologically benign lymph node are present. Ink is seen on the tumour. | ||
====Biopsy==== | |||
The sections show a lesion with spindled (myoepithelial) cells and an epithelial component, on a background of a chondromyxoid stroma. No nuclear atypia is apparent. Mitotic activity is not identified. | |||
<pre> | |||
The tumour stains as follows: | |||
POSITIVE: CK7, S-100, SMA, GFAP (patchy). | |||
NEGATIVE: (none). | |||
PROLIFERATION (Ki-67): <2%. | |||
</pre> | |||
==See also== | ==See also== | ||
*[[Salivary glands]]. | *[[Salivary glands]]. | ||
*[[Salivary gland cytopathology]]. | |||
==References== | ==References== | ||