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Difference between revisions of "TFE3"
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'''TFE3''' is an [[immunostain]] used in [[uropathology]] and [[soft tissue pathology]]. | '''TFE3''' is an [[immunostain]] used in [[uropathology]] and [[soft tissue pathology]]. | ||
The reliability of the immunostain for detecting TFE3 rearrangments has been questioned by at least one study.<ref name=pmid30851332>{{cite journal |vauthors=Sharain RF, Gown AM, Greipp PT, Folpe AL |title=Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, 2-laboratory study |journal=Hum Pathol |volume=87 |issue= |pages=65–74 |date=May 2019 |pmid=30851332 |doi=10.1016/j.humpath.2019.02.008 |url=}}</ref> | |||
==Negative== | ==Negative== | ||
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*[[Alveolar soft part sarcoma]]. | *[[Alveolar soft part sarcoma]]. | ||
* YAP-TFE3 translocated [[epithelioid hemangioendothelioma]] | * YAP-TFE3 translocated [[epithelioid hemangioendothelioma]] | ||
*[[Epithelioid angiomyolipoma]] | *[[Epithelioid angiomyolipoma]]. | ||
*[[Granular cell | *[[Granular cell tumour]].<ref>{{cite journal |authors=Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM |title=Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study |journal=Hum. Pathol. |volume=45 |issue=5 |pages=1039–44 |date=May 2014 |pmid=24746209 |doi=10.1016/j.humpath.2013.12.021 |url=}}</ref> | ||
==See also== | ==See also== | ||